{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:34:32Z","timestamp":1760243672693,"version":"build-2065373602"},"reference-count":58,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:00:00Z","timestamp":1666828800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/summer-heart-0930.chufeiyun1688.workers.dev:443\/https\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006242","name":"Universiti Malaysia Sabah","doi-asserted-by":"publisher","award":["DKC2008"],"award-info":[{"award-number":["DKC2008"]}],"id":[{"id":"10.13039\/501100006242","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Data"],"abstract":"<jats:p>The spike glycoprotein (S protein), 3-chymotrypsin-like protease (3CL-Pro), and papain-like protease (PL-Pro) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus are widely targeted for the discovery of therapeutic compounds against this virus. Dietary flavonoid compounds were proposed as a candidate for safe therapy for COVID-19 patients. Nevertheless, wet lab experiments for high-throughput screening of the compounds are undoubtedly time and cost consuming. This study aims to screen dietary flavonoid compounds that bind to S protein, 3CL-Pro, and PL-Pro of SARS-CoV-2. For this purpose, protein structures of the receptor-binding domain (RBD) of S protein (6M0J), 3CL-Pro (6LU7), and PL-Pro (6W9C) were retrieved from the RCSB Protein Data Bank (PDB). Twelve dietary flavonoid compounds were selected for the studies on their binding affinity to the targeted proteins by global and local docking. The docking and molecular dynamic (MD) simulations were performed using YASARA software. Out of 12 compounds, the highest binding score was observed between hesperidin against RBD S protein (\u22129.98 kcal\/mol), 3CL-Pro (\u22129.43 kcal\/mol), and PL-Pro (\u22128.89 kcal\/mol) in global docking. Interestingly, MD simulation revealed that the complex between 3CL-Pro and RBD S protein has better stability than PL-Pro. This study suggests that hesperidin might have versatile inhibitory properties against several essential proteins of SARS-CoV-2. This study, nevertheless, remains to be confirmed through in vitro and in vivo assays.<\/jats:p>","DOI":"10.3390\/data7110144","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T20:37:58Z","timestamp":1666903078000},"page":"144","update-policy":"https:\/\/summer-heart-0930.chufeiyun1688.workers.dev:443\/https\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Technical Data of In Silico Analysis of the Interaction of Dietary Flavonoid Compounds against Spike-Glycoprotein and Proteases of SARS-CoV-2"],"prefix":"10.3390","volume":"7","author":[{"given":"Nurbella Sofiana","family":"Altu","sequence":"first","affiliation":[{"name":"Biotechnology Research Institute, Universiti Malaysia Sabah, Kota Kinabalu 88400, Sabah, Malaysia"}]},{"given":"Cahyo","family":"Budiman","sequence":"additional","affiliation":[{"name":"Biotechnology Research Institute, Universiti Malaysia Sabah, Kota Kinabalu 88400, Sabah, Malaysia"}]},{"ORCID":"https:\/\/summer-heart-0930.chufeiyun1688.workers.dev:443\/https\/orcid.org\/0000-0002-2844-4477","authenticated-orcid":false,"given":"Rafida","family":"Razali","sequence":"additional","affiliation":[{"name":"Biotechnology Research Institute, Universiti Malaysia Sabah, Kota Kinabalu 88400, Sabah, Malaysia"}]},{"ORCID":"https:\/\/summer-heart-0930.chufeiyun1688.workers.dev:443\/https\/orcid.org\/0000-0001-5217-7607","authenticated-orcid":false,"given":"Ruzaidi Azli Mohd","family":"Mokhtar","sequence":"additional","affiliation":[{"name":"Biotechnology Research Institute, Universiti Malaysia Sabah, Kota Kinabalu 88400, Sabah, Malaysia"}]},{"ORCID":"https:\/\/summer-heart-0930.chufeiyun1688.workers.dev:443\/https\/orcid.org\/0000-0002-8284-4981","authenticated-orcid":false,"given":"Khairul Azfar","family":"Kamaruzaman","sequence":"additional","affiliation":[{"name":"Biotechnology Research Institute, Universiti Malaysia Sabah, Kota Kinabalu 88400, Sabah, Malaysia"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"104212","DOI":"10.1016\/j.meegid.2020.104212","article-title":"Full-genome evolutionary analysis of the novel coronavirus (2019-nCoV) rejects the hypothesis of emergence as a result of a recent recombination event","volume":"79","author":"Paraskevis","year":"2020","journal-title":"Infect. Genet. Evol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/S0140-6736(20)31022-9","article-title":"Remdesivir in adults with severe COVID-19: A randomised, double-blind, placebo-controlled, multicentre trial","volume":"395","author":"Wang","year":"2020","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1093\/cid\/ciaa237","article-title":"In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","volume":"71","author":"Yao","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Zhang, Y., and Ma, Z.F. (2020). Impact of the COVID-19 pandemic on mental health and quality of life among local residents in Liaoning province, China: A cross-sectional study. Int. J. Environ. Res., 17.","DOI":"10.3390\/ijerph17072381"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1080\/14760584.2022.2008245","article-title":"What are the challenges faced by COVID-19 vaccines?","volume":"21","author":"Abdalla","year":"2021","journal-title":"Expert Rev. Vaccines"},{"key":"ref_6","unstructured":"World Health Organization (2022, April 17). Tracking SARS-CoV-2 Variants. Available online: https:\/\/summer-heart-0930.chufeiyun1688.workers.dev:443\/https\/www.who.int\/en\/activities\/tracking-SARS-CoV-2-variants\/."},{"key":"ref_7","unstructured":"(2021, April 17). Coronavirus disease (COVID-19) pandemic (World Health Organization). Available online: https:\/\/summer-heart-0930.chufeiyun1688.workers.dev:443\/https\/www.who.int\/emergencies\/diseases\/novel-coronavirus-2019."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"105923","DOI":"10.1016\/j.ijantimicag.2020.105923","article-title":"Chloroquine for the 2019 novel coronavirus SARS-CoV-2","volume":"55","author":"Colson","year":"2020","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Razali, R., Subbiah, V.J., and Budiman, C. (2021). Technical data of heterologous expression and purification of SARS-CoV-2 proteases using Escherichia coli system. Data, 6.","DOI":"10.3390\/data6090099"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.medj.2020.06.001","article-title":"Outcomes of hydroxychloroquine usage in United States veterans hospitalized with COVID-19","volume":"1","author":"Magagnoli","year":"2020","journal-title":"Med"},{"key":"ref_11","first-page":"102","article-title":"Cardiovascular disease, drug therapy, and mortality in COVID-19","volume":"382","author":"Mehra","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Losso, J.N. (2020). The potential of dietary bioactive compounds against SARS-CoV-2 and COVID-19 induced endothelial dysfunction. Molecules, 27.","DOI":"10.3390\/molecules27051623"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"108768","DOI":"10.1016\/j.jnutbio.2021.108768","article-title":"Dietary bioactive compounds as modulators of mitochondrial function","volume":"96","author":"Noriega","year":"2021","journal-title":"J. Nutr. Biochem."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Andr\u00e9s-Lacueva, C., Medina-Remon, A., Llorach, R., Urpi-Sarda, M., Khan, N., Chiva-Blanch, G., Zamora-Ros, R., Rotches-Ribalta, M., and Lamuela-Ravent\u00f3s, R.M. (2009). Phenolic Compounds: Chemistry and Occurrence in Fruits and Vegetables. Fruit and Vegetable Phytochemicals: Chemistry, Nutritional Value, and Stability, Blackwell Publishing.","DOI":"10.1002\/9780813809397.ch2"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Ramawat, K.G., and Merillon, J.M. (2008). Drug Discovery from Plants. Bioactive Molecules and Medicinal Plants, Springer.","DOI":"10.1007\/978-3-540-74603-4"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"107588","DOI":"10.1016\/j.dib.2021.107588","article-title":"Technical data on the inhibition properties of some medicinal plant extracts towards caseinolytic protease proteolytic subunit of Plasmodium knowlesi","volume":"39","author":"Razak","year":"2021","journal-title":"Data Brief"},{"key":"ref_17","first-page":"79","article-title":"Flavonoids\u2014Food sources and health benefits","volume":"65","year":"2014","journal-title":"Rocz. Panstw. Zakl. Hig."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s11101-021-09759-z","article-title":"Flavonoids are promising safe therapy against COVID-19","volume":"21","author":"Alzaabi","year":"2021","journal-title":"Phytochem. Rev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"111049","DOI":"10.1016\/j.nut.2020.111049","article-title":"In silico screening of potential anti-COVID-19 bioactive natural constituents from food sources by molecular docking","volume":"82","author":"Xu","year":"2021","journal-title":"Nutrition"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/s41589-020-00689-z","article-title":"SARS-CoV-2 Mpro inhibitors and activity-based probes for patient-sample imaging","volume":"17","author":"Rut","year":"2021","journal-title":"Nat. Chem. Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s12985-021-01526-y","article-title":"Precision therapeutic targets for COVID-19","volume":"18","author":"Krumm","year":"2021","journal-title":"Virol. J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/s41467-021-21060-3","article-title":"Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors","volume":"12","author":"Osipiuk","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Razali, R., Asis, H., and Budiman, C. (2021). Structure-function characteristics of SARS-CoV-2 proteases and their potential inhibitors from microbial sources. Microorganisms, 9.","DOI":"10.3390\/microorganisms9122481"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Kaul, R., Paul, P., Kumar, S., B\u00fcsselberg, D., Dwivedi, V.D., and Chaari, A. (2021). Promising Antiviral Activities of Natural Flavonoids against SARS-CoV-2 Targets: Systematic Review. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222011069"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Bellavite, P., and Donzelli, A. (2020). Hesperidin and SARS-CoV-2: New Light on the Healthy Function of Citrus Fruits. Antioxidants, 9.","DOI":"10.20944\/preprints202006.0321.v1"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"675287","DOI":"10.3389\/fphar.2021.675287","article-title":"Curcumin as a potential treatment for COVID-19","volume":"12","author":"Rattis","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"865097","DOI":"10.3389\/fphar.2022.865097","article-title":"Modeling Kaempferol as a Potential Pharmacological Agent for COVID-19\/PF Co-Occurrence Based on Bioinformatics and System Pharmacological Tools","volume":"13","author":"Jiang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Kiokias, S., and Oreopoulou, V. (2021). A Review of the Health Protective Effects of Phenolic Acids against a Range of Severe Pathologic Conditions (Including Coronavirus-Based Infections). Molecules, 26.","DOI":"10.3390\/molecules26175405"},{"key":"ref_29","first-page":"21203","article-title":"Inhibition of COVID-19 RNA-Dependent R.N.A. Polymerase by Natural Bioactive Compounds: Molecular Docking Analysis","volume":"10","author":"Shehata","year":"2020","journal-title":"Res. Sq."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Soltane, R., Chrouda, A., Mostafa, A., Al-Karmalawy, A.A., Choua\u00efb, K., Dhahri, A., Pashameah, R.A., Alasiri, A., Kutkat, O., and Shehata, M. (2021). Strong Inhibitory Activity and Action Modes of Synthetic Maslinic Acid Derivative on Highly Pathogenic Coronaviruses: COVID-19 Drug Candidate. Pathogens, 10.","DOI":"10.3390\/pathogens10050623"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"5515","DOI":"10.1080\/07391102.2021.1871863","article-title":"Flavonol morin targets host ACE2, IMP-\u03b1, PARP-1 and viral proteins of SARS-CoV-2, SARS-CoV and MERS-CoV critical for infection and survival: A computational analysis","volume":"40","author":"Gupta","year":"2022","journal-title":"J. Biomol. Struct. Dyn."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Wang, Y.Q., Li, Q.S., Zheng, X.Q., Lu, J.L., and Liang, Y.R. (2021). Antiviral Effects of Green Tea E.G.C.G. and Its Potential Application against COVID-19. Molecules, 26.","DOI":"10.3390\/molecules26133962"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Ohishi, T., Hishiki, T., Baig, M.S., Rajpoot, S., Saqib, U., Takasaki, T., and Hara, Y. (2022). Epigallocatechin gallate (E.G.C.G.) attenuates severe acute respiratory coronavirus disease 2 (SARS-CoV-2) infection by blocking the interaction of SARS-CoV-2 spike protein receptor-binding domain to human angiotensin-converting enzyme 2. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0271112"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"102214","DOI":"10.1016\/j.jksus.2022.102214","article-title":"An in-silico investigation of potential natural polyphenols for the targeting of COVID main protease inhibitor","volume":"34","author":"Aljarba","year":"2022","journal-title":"J. King Saud Univ. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"653","DOI":"10.4103\/ijmr.IJMR_3046_20","article-title":"Breaking tolerance to pancreatic cancer unresponsiveness to chemotherapy","volume":"154","author":"Govardhanagiri","year":"2021","journal-title":"Indian J. Med. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1039\/C8MD90019A","article-title":"What are the drugs of the future?","volume":"9","author":"Ngo","year":"2018","journal-title":"Med. Chem. Comm."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11130-016-0590-1","article-title":"Curcumin, a compound from natural sources, a true scientific challenge\u2014A review","volume":"72","year":"2017","journal-title":"Plant Foods Hum. Nutri."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"961","DOI":"10.3945\/an.116.012575","article-title":"Improvements in metabolic health with consumption of ellagic acid and subsequent conversion into urolithins: Evidence and mechanisms","volume":"7","author":"Kang","year":"2016","journal-title":"Adv. Nutr."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3389\/fnut.2019.00030","article-title":"Effect of \u03b1-glucosylation on the stability, antioxidant properties, toxicity, and neuroprotective activity of (\u2013)-epigallocatechin gallate","volume":"6","author":"Ballesteros","year":"2019","journal-title":"Front. Nutr."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"362","DOI":"10.2174\/138920101504140825120737","article-title":"Polyphenols: Well beyond the antioxidant capacity: Gallic acid and related compounds as neuroprotective agents: You are what you eat!","volume":"15","author":"Daglia","year":"2014","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1038\/s41598-020-79287-x","article-title":"(\u2212)Gallocatechin gallate from green tea rescues cognitive impairment through restoring hippocampal silent synapses in post-menopausal depression","volume":"11","author":"Ko","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1080\/13880209.2018.1474931","article-title":"Galangin, a dietary flavonoid, ameliorates hyperglycaemia and lipid abnormalities in rats with streptozotocin-induced hyperglycaemia","volume":"56","author":"Aloud","year":"2018","journal-title":"Pharm. Biol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Rehman, M.F., Batool, A.I., Qadir, R., and Aslam, M. (2021). Chapter 18: Hesperidin and naringenin. A Centum of Valuable Plant Bioactives, Elsevier Academic Press.","DOI":"10.1016\/B978-0-12-822923-1.00027-3"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1016\/j.foodchem.2012.11.139","article-title":"A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention","volume":"138","author":"Chen","year":"2013","journal-title":"Food Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"11538","DOI":"10.3390\/molecules190811538","article-title":"Maslinic acid, a natural phytoalexin-type triterpene from olives\u2014A promising nutraceutical?","volume":"19","author":"Juan","year":"2014","journal-title":"Molecules"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Li, Y., Yao, J., Han, C., Yang, J., Chaudhry, M., Wang, S., Liu, H., and Yin, Y. (2016). Quercetin, inflammation, and immunity. Nutrients, 8.","DOI":"10.3390\/nu8030167"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jsps.2016.04.025","article-title":"The pharmacological potential of rutin","volume":"25","author":"Ganeshpurkar","year":"2017","journal-title":"Saudi Pharm. J."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"774","DOI":"10.2174\/0929867323666160106150821","article-title":"Morin: A promising natural drug","volume":"23","author":"Caselli","year":"2016","journal-title":"Curr. Med. Chem."},{"key":"ref_49","unstructured":"Abelian, A., Dybek, M., Wallach, J., Gaye, B., and Adejare, A. (1999). Chapter 6: Pharmaceutical Chemistry. Remington: The Science and Practice of Pharmacy, Lippincott Williams and Wilkins."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"730","DOI":"10.56499\/jppres21.1080_9.5.730","article-title":"Natural products repurposing of the H5N1-based lead compounds for the most fit inhibitors against 3C-like protease of SARS-CoV-2","volume":"9","author":"Parikesit","year":"2021","journal-title":"J. Pharm. Pharmacogn. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1080\/07391102.2020.1835729","article-title":"Screening of phytochemicals as potent inhibitor of 3-chymotrypsin and papain-like proteases of SARS-CoV-2: An in silico approach to combat COVID-19","volume":"40","author":"Swargiary","year":"2020","journal-title":"J. Biomol. Struct. Dyn."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3972","DOI":"10.2174\/1381612824666181106111020","article-title":"Prospecting and Structural Insight into the Binding of Novel Plant-Derived Molecules of Leea indica as inhibitors of BACE1","volume":"24","author":"Hosen","year":"2018","journal-title":"Curr. Pharm. Des."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.tibtech.2007.10.007","article-title":"Enzyme activation for organic solvents made easy","volume":"26","author":"Serdakowski","year":"2008","journal-title":"Trends Biotechnol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e3341","DOI":"10.7717\/peerj.3341","article-title":"Lid opening and conformational stability of T1 Lipase is mediated by increasing chain length polar solvents","volume":"5","author":"Maiangwa","year":"2017","journal-title":"PeerJ"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"599079","DOI":"10.3389\/fmolb.2020.599079","article-title":"In silico screening of natural compounds as potential inhibitors of SARS-CoV-2 main protease and spike RBD: Targets for COVID-19","volume":"7","author":"Teli","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.1038\/s41467-020-16954-7","article-title":"Structural plasticity of SARS-CoV-2 3CL Mpro active site cavity revealed by room temperature X-ray crystallography","volume":"11","author":"Kneller","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.antiviral.2014.12.015","article-title":"The SARS-coronavirus papain-like protease: Structure, function and inhibition by designed antiviral compounds","volume":"115","author":"Mesecar","year":"2015","journal-title":"Antiviral Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/prot.10104","article-title":"Increasing the precision of comparative models with YASARA NOVA\u2014A self-parameterizing force field","volume":"47","author":"Krieger","year":"2002","journal-title":"Proteins"}],"container-title":["Data"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/summer-heart-0930.chufeiyun1688.workers.dev:443\/https\/www.mdpi.com\/2306-5729\/7\/11\/144\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:04:23Z","timestamp":1760144663000},"score":1,"resource":{"primary":{"URL":"https:\/\/summer-heart-0930.chufeiyun1688.workers.dev:443\/https\/www.mdpi.com\/2306-5729\/7\/11\/144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,27]]},"references-count":58,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["data7110144"],"URL":"https:\/\/summer-heart-0930.chufeiyun1688.workers.dev:443\/https\/doi.org\/10.3390\/data7110144","relation":{},"ISSN":["2306-5729"],"issn-type":[{"type":"electronic","value":"2306-5729"}],"subject":[],"published":{"date-parts":[[2022,10,27]]}}}