{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T08:27:56Z","timestamp":1762072076551,"version":"build-2065373602"},"reference-count":28,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:00:00Z","timestamp":1666828800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/summer-heart-0930.chufeiyun1688.workers.dev:443\/https\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Data"],"abstract":"<jats:p>Cardiovascular diseases are commonly caused by atherosclerosis, stenosis and aneurysms. Understanding the influence of these pathological conditions on the circulatory mechanism is required to establish methods for early diagnosis. Different tools have been developed to simulate healthy and pathological conditions of blood flow. These simulations are often based on computational models that allow the generation of large data sets for further investigation. However, because computational models often lack some aspects of real-world data, hardware simulators are used to close this gap and generate data for model validation. The aim of this study is to develop and validate a hardware simulator to generate benchmark data sets of healthy and pathological conditions. The development process was led by specific design criteria to allow flexible and physiological simulations. The in vitro hardware simulator includes the major 33 arteries and is driven by a ventricular assist device generating a parametrised in-flow condition at the heart node. Physiologic flow conditions, including heart rate, systolic\/diastolic pressure, peripheral resistance and compliance, are adjustable across a wide range. The pressure and flow waves at 17 + 1 locations are measured by inverted fluid-resistant pressure transducers and one ultrasound flow transducer, supporting a detailed analysis of the measurement data even for in silico modelling applications. The pressure and flow waves are compared to in vivo measurements and show physiological conditions. The influence of the degree and location of the stenoses on blood pressure and flow was also investigated. The results indicate decreasing translesional pressure and flow with an increasing degree of stenosis, as expected. The benchmark data set is made available to the research community for validating and comparing different types of computational models. It is hoped that the validation and improvement of computational simulation models will provide better clinical predictions.<\/jats:p>","DOI":"10.3390\/data7110145","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T20:37:58Z","timestamp":1666903078000},"page":"145","update-policy":"https:\/\/summer-heart-0930.chufeiyun1688.workers.dev:443\/https\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["In Vitro Major Arterial Cardiovascular Simulator to Generate Benchmark Data Sets for In Silico Model Validation"],"prefix":"10.3390","volume":"7","author":[{"given":"Michelle","family":"Wisotzki","sequence":"first","affiliation":[{"name":"Technische Hochschule Mittelhessen, Faculty of Life Science Engineering, Institute of Biomedical Engineering (IBMT), Wiesenstrasse 14, 35390 Giessen, Germany"}]},{"given":"Alexander","family":"Mair","sequence":"additional","affiliation":[{"name":"Technische Hochschule Mittelhessen, Faculty of Life Science Engineering, Institute of Biomedical Engineering (IBMT), Wiesenstrasse 14, 35390 Giessen, Germany"}]},{"given":"Paul","family":"Schlett","sequence":"additional","affiliation":[{"name":"Technische Hochschule Mittelhessen, Faculty of Life Science Engineering, Institute of Biomedical Engineering (IBMT), Wiesenstrasse 14, 35390 Giessen, Germany"}]},{"given":"Bernhard","family":"Lindner","sequence":"additional","affiliation":[{"name":"Technische Hochschule Mittelhessen, Faculty of Life Science Engineering, Institute of Biomedical Engineering (IBMT), Wiesenstrasse 14, 35390 Giessen, Germany"}]},{"given":"Max","family":"Oberhardt","sequence":"additional","affiliation":[{"name":"Technische Hochschule Mittelhessen, Faculty of Life Science Engineering, Institute of Biomedical Engineering (IBMT), Wiesenstrasse 14, 35390 Giessen, Germany"}]},{"ORCID":"https:\/\/summer-heart-0930.chufeiyun1688.workers.dev:443\/https\/orcid.org\/0000-0002-4920-523X","authenticated-orcid":false,"given":"Stefan","family":"Bernhard","sequence":"additional","affiliation":[{"name":"Technische Hochschule Mittelhessen, Faculty of Life Science Engineering, Institute of Biomedical Engineering (IBMT), Wiesenstrasse 14, 35390 Giessen, Germany"},{"name":"Department of Mathematics and Computer Science, Freie Universit\u00e4t Berlin, Arnimallee 6, 14195 Berlin, Germany"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/S0140-6736(13)61249-0","article-title":"Comparison of global estimates of prevalence and risk factors for peripheral artery disease in 2000 and 2010: A systematic review and analysis","volume":"382","author":"Fowkes","year":"2013","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1159\/000047680","article-title":"Prevalence of and risk factors associated with carotid artery stenosis: The Troms\u00f8 Study","volume":"12","author":"Mathiesen","year":"2001","journal-title":"Cerebrovasc. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"H1472","DOI":"10.1152\/ajpheart.2001.280.4.H1472","article-title":"Infinite number of solutions to the hemodynamic inverse problem","volume":"280","author":"Quick","year":"2001","journal-title":"Am. J. Physiol.-Heart Circ. Physiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.compbiomed.2017.05.021","article-title":"Simulation, identification and statistical variation in cardiovascular analysis (SISCA)\u2014A software framework for multi-compartment lumped modeling","volume":"87","author":"Huttary","year":"2017","journal-title":"Comput. Biol. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.mbs.2015.09.001","article-title":"Parametric uncertainty and global sensitivity analysis in a model of the carotid bifurcation: Identification and ranking of most sensitive model parameters","volume":"269","author":"Gul","year":"2015","journal-title":"Math. Biosci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.cma.2016.01.007","article-title":"Geometric multiscale modeling of the cardiovascular system, between theory and practice","volume":"302","author":"Quarteroni","year":"2016","journal-title":"Comput. Methods Appl. Mech. Eng."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s007910100063","article-title":"Coupling between lumped and distributed models for blood flow problems","volume":"4","author":"Quarteroni","year":"2001","journal-title":"Comput. Vis. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Zenker, S., Rubin, J., and Clermont, G. (2007). From inverse problems in mathematical physiology to quantitative differential diagnoses. PLoS Comput. Biol., 3.","DOI":"10.1371\/journal.pcbi.0030204"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1007\/s11831-021-09685-5","article-title":"The Critical Role of Lumped Parameter Models in Patient-Specific Cardiovascular Simulations","volume":"29","author":"Garber","year":"2021","journal-title":"Arch. Comput. Methods Eng."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.bbe.2017.08.001","article-title":"Lumped models of the cardiovascular system of various complexity","volume":"37","year":"2017","journal-title":"Biocybern. Biomed. Eng."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Jones, G., Parr, J., Nithiarasu, P., and Pant, S. (2021). A physiologically realistic virtual patient database for the study of arterial haemodynamics. Int. J. Numer. Methods Biomed. Eng., e3497.","DOI":"10.1002\/cnm.3497"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e02732","DOI":"10.1002\/cnm.2732","article-title":"A benchmark study of numerical schemes for one-dimensional arterial blood flow modelling","volume":"31","author":"Boileau","year":"2015","journal-title":"Int. J. Numer. Methods Biomed. Eng."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s10439-022-02943-y","article-title":"Special Issue of the VPH2020 Conference:Virtual Physiological Human: When Models, Methods and Experiments Meet the Clinic","volume":"50","author":"Chapelle","year":"2022","journal-title":"Ann. Biomed. Eng."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"20200881","DOI":"10.1098\/rsif.2020.0881","article-title":"Arterial pulse wave propagation across stenoses and aneurysms: Assessment of one-dimensional simulations against three-dimensional simulations and in vitro measurements","volume":"18","author":"Jin","year":"2021","journal-title":"J. R. Soc. Interface"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s11548-017-1679-1","article-title":"VCSim3: A VR simulator for cardiovascular interventions","volume":"13","author":"Korzeniowski","year":"2018","journal-title":"Int. J. Comput. Assist. Radiol. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1097\/MAT.0000000000000880","article-title":"Development and Validation of a Life-Sized Mock Circulatory Loop of the Human Circulation for Fluid-Mechanical Studies","volume":"65","author":"Gehron","year":"2019","journal-title":"ASAIO J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1097\/00002480-200209000-00009","article-title":"A Hybrid Mock Circulatory System: Testing a Prototype Under Physiologic and Pathological Conditions","volume":"48","author":"Ferrari","year":"2002","journal-title":"ASAIO J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s10527-015-9542-6","article-title":"Simulator for Modeling the Cardiovascular System for Testing Circulatory Assist Devices","volume":"49","author":"Pugovkin","year":"2015","journal-title":"Biomed. Eng."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Pugovkin, A.A., and Telyshev, D.V. (2017, January 29\u201330). Automated pediatric cardiovascular simulator for left ventricular assist device evaluation. Proceedings of the 2017 International Siberian Conference on Control and Communications (SIBCON), Astana, Kazakhstan.","DOI":"10.1109\/SIBCON.2017.7998543"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Bernhard, S., Wisotzki, M., Schlett, P., Lindner, B., Mair, A., and Oberhardt, M. (2022). In-vitro Major Arterial Cardiovascular Simulator: Benchmark Data Set for in-silico Model Validation. arXiv.","DOI":"10.3390\/data7110145"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1177\/026765910001500409","article-title":"The Medos ventricular assist device system","volume":"15","author":"Thuaudet","year":"2000","journal-title":"Perfusion"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1475-925X-5-42","article-title":"Transient integral boundary layer method to calculate the translesional pressure drop and the fractional flow reserve in myocardial bridges","volume":"5","author":"Bernhard","year":"2006","journal-title":"Biomed. Eng. Online"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1001\/archinte.1984.00350140192026","article-title":"Wave Reflections and the Arterial Pulse","volume":"144","author":"Yaginuma","year":"1984","journal-title":"Arch. Intern. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"371","DOI":"10.3109\/00365517409082508","article-title":"Systolic Pressure Amplification in the Arteries of Normal Subjects","volume":"33","author":"Nielsen","year":"1974","journal-title":"Scand. J. Clin. Lab. Investig."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1161\/01.CIR.62.1.105","article-title":"A. Aortic input impedance in normal man: Relationship to pressure wave forms","volume":"62","author":"Murgo","year":"1980","journal-title":"Circulation"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3476","DOI":"10.1016\/j.jbiomech.2007.05.027","article-title":"Pulse wave propagation in a model human arterial network: Assessment of 1-D numerical simulations against in vitro measurements","volume":"40","author":"Matthys","year":"2007","journal-title":"J. Biomech."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1177\/0954411919859994","article-title":"The speed, reflection and intensity of waves propagating in flexible tubes with aneurysm and stenosis: Experimental investigation","volume":"233","author":"Hacham","year":"2019","journal-title":"Proc. Inst. Mech. Eng. Part H J. Eng. Med."},{"key":"ref_28","unstructured":"Huttary, R., Maier, A., and Bernhard, S. (2022, April 06). agbernhard.lse.thm.de\/SISCA, GitLab. Available online: https:\/\/summer-heart-0930.chufeiyun1688.workers.dev:443\/https\/gitlab.com\/agbernhard.lse.thm\/sisca\/."}],"container-title":["Data"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/summer-heart-0930.chufeiyun1688.workers.dev:443\/https\/www.mdpi.com\/2306-5729\/7\/11\/145\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:04:31Z","timestamp":1760144671000},"score":1,"resource":{"primary":{"URL":"https:\/\/summer-heart-0930.chufeiyun1688.workers.dev:443\/https\/www.mdpi.com\/2306-5729\/7\/11\/145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,27]]},"references-count":28,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["data7110145"],"URL":"https:\/\/summer-heart-0930.chufeiyun1688.workers.dev:443\/https\/doi.org\/10.3390\/data7110145","relation":{},"ISSN":["2306-5729"],"issn-type":[{"type":"electronic","value":"2306-5729"}],"subject":[],"published":{"date-parts":[[2022,10,27]]}}}