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Lewis remained at UCH for the rest of his life, beginning as a [[Foundation house officer|house physician]]. From 1907 he also worked at the [[Royal Naval Hospital, Greenwich]] and the [[London Chest Hospital|City of London Hospital]] and the same year he took his [[Doctor of Medicine]] (MD) degree. In 1911 he was appointed lecturer in cardiac [[pathology]] at UCH and in 1913 was promoted to assistant physician in clinical work. He was elected [[Fellow of the Royal College of Physicians]] (FRCP) in 1913.
While still a house physician, Lewis began [[physiology|physiological]] research, carrying out fundamental research on the heart, the [[pulse]] and [[blood pressure]]. From 1906, he corresponded with the Dutch physiologist [[Willem Einthoven]] concerning the latter's invention of the string galvanometer and [[electrocardiography]], and Lewis pioneered its use in clinical settings. Accordingly, Lewis is considered the "father of clinical cardiac electrophysiology". The first use of electrocardiography in clinical medicine was in 1908. In that year, Thomas Lewis and [[Arthur MacNalty]] (later the [[Chief Medical Officer (United Kingdom)|Chief Medical Officer of the United Kingdom]]) employed electrocardiography to diagnose [[heart block]].<ref>”A note on the simultaneous occurrence of sinus and ventricular rhythm in man”, Lewis T, Macnalty AS, ''J. Physiol.'' 1908 Dec 15;37(5–6):445-58</ref> In 1909, with [[Sir James Mackenzie|James MacKenzie]], Lewis founded the journal ''Heart: A Journal for the Study of the Circulation'', which he renamed ''[[Clinical Science (journal)|Clinical Science]]'' in 1933. In 1913, he published the book ''Clinical Electrocardiography'', the first treaty on electrocardiography. Lewis was elected a [[Fellow of the Royal Society]] (FRS) in 1918.<ref name="frs">{{Cite journal | last1 = Drury | first1 = A. N. | last2 = Grant | first2 = R. T. | doi = 10.1098/rsbm.1945.0012 | title = Thomas Lewis. 1881-1945 | journal = [[Obituary Notices of Fellows of the Royal Society]] | volume = 5 | issue = 14 | pages = 179 | year = 1945 | s2cid = 72220548 }}</ref> He was promoted to full physician at UCH in 1919.
[[File:The soldier's heart and the effort syndrome Wellcome L0027240.jpg|thumb|The soldier's heart and the effort syndrome]][[File:Thomas Lewis electrocardiograph (2).jpeg|alt=Electrocardiograph, a large wooden, workbench-like machine, with metal switches on the front face|thumb|Electrocardiograph, used by Sir Thomas Lewis at University College Hospital, London, by the Cambridge Instrument Co. 1930.]]
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