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'''Possible relations to Addison's Disease'''
 
It has been proposed by some specialists that Chronic Fatigue Syndrome is a form of Addison's disease (referred to as adrenal insufficiency or hypoadrenalism). The following evidence has been presented 'In view of the 36 features shared by Chronic Fatigue Syndrome and Addison’s disease, including hypocortisolism and a host of neuropsychological complaints<ref name="Lancet99">Cleare AJ, Heap E, Malhi GS, Wessely S, O’Keane V, Miell J. 1999 Low-dose hydrocortisone in chronic fatigue syndrome: a randomised crossover trial. Lancet. 353:455–458.</ref><ref name="Metab2000">Hunt PJ, Gurnell EM, Huppert FA, Richards C, Prevost AT, Wass JA, Herbert J, Chatterjee VK. ''Improvement in mood and fatigue after dehydroepiandrosterone replacement in Addison’s disease in a randomized, double blind trial.'' J Clin Endocrinol Metab 2000; 85:4650–6.</ref><ref name="prohealth">Role of the Endocrine System in Chronic Fatigue Syndrome, Pro Health, ProHealth.com [http://www.immunesupport.com/library/endocrine-system.htm]</ref><ref name="euro">'Similarity of symptoms in chronic fatigue syndrome and Addison's disease' ''European Journal of Clinical Investigation'' Volume 27, Issue 12, page 1062, December 1997 [http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2362.1997.2380785.x/abstract]</ref><ref name="dummies">''Chronic Fatigue Syndrome for Dummies'' By Susan R. Lisman, Karla Dougherty, Chapter 3, page 49</ref><ref name="Journal of Clinical Endocrinology">The Journal of Clinical Endocrinology & Metabolism Vol. 84, No. 6 2263-2264 1999, Investigations of Hydrocortisone and Fludrocortisone in the Treatment of Chronic Fatigue Syndrome, Riccardo Baschetti, M.D. [http://jcem.endojournals.org/cgi/content/full/84/6/2263-a#R1]</ref><ref name="Baschetti99">Baschetti R. 1999 Psychological factors and chronic fatigue syndrome. NZ Med J. 112:58–59</ref> and investigations of the effects ofafter hydrocortisonesupplementation pluswith mineralocorticoids (fludrocortisone), low-dose hydrocortisone (cortisol) in the treatment of CFS’.<ref name="Baschetti2000">Baschetti R. ''Chronic fatigue syndrome: a form of Addison’s disease.'' J Intern Med 2000; 247:737–9.</ref><ref name="Naschitz2003">Naschitz JE, Rosner I, Rozenbaum M, Naschitz S, Musafia-Priselac R, Shaviv N, Fields M, Isseroff H, Zuckerman E, Yeshurun D, Sabo E. ''The head-up tilt test with haemodynamic instability score in diagnosing chronic fatigue syndrome.'' Q J Med 2003; 96:133–42.</ref><ref name="Baschetti2001">Baschetti R. Chronic fatigue syndrome, decreased exercise capacity, and adrenal insufficiency. Arch Intern Med 2001; 161:1558–9.</ref><ref name="IntJMolMed1998">Kuratsune H, Yamaguti K, Sawada M, Kodate S, Machii T, Kanakura Y, Kitani T. Dehydroepiandrosterone sulfate deficiency in chronic fatigue syndrome. Int J Mol Med 1998; 1:143–6.</ref>
 
• Many of the symptoms of CFS overlap those of Addison's disease (adrenal failure).