Talk:Intermittent fasting: Difference between revisions

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Potential Inclusion of 'fasting in the media' section - two television documentaries, a few media artciles, also some medical references (to be sorted through to see if any worthy or not of inclusion and remove the irrelavant and less credible sources)
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:I just pressed the Random Article button fifty times, and not a single one had a criticism section. I don't think criticism sections are as common as you think. Though if you find some well sourced criticism on the subject of this article, feel free to put it in the page [[User:Doopbridge|Doopbridge]] ([[User talk:Doopbridge|talk]]) 08:22, 7 August 2012 (UTC)
::Criticism sections [[Wikipedia:criticism#Avoid sections and articles focusing on "criticisms" or "controversies"|aren't always a good way of writing an article.]] If there's anything critical to say, then it's often best to include it within the main body of text as appropriate. So, for instance, if a study showed that intermittent fasting was useless against hypertension, then it should go into a section or paragraph about hypertension. [[User:Sophie means wisdom|Sophie means wisdom]] ([[User talk:Sophie means wisdom|talk]]) 19:09, 17 August 2012 (UTC)
 
 
 
 
== Fasting In the Media ==
A potential inlusion of a 'Fasting in the media' section
 
* <B>“The Science of Fasting” (TV Documentary on ARTE)</B> http://www.youtube.com/watch?v=sNdWCZWpjxU http://www.buchinger.com/en/news-stories/latest-news/newsinhalt/detail/2012/april/24/Scientific-documentary-on-fasting8232.html http://www.viadecouvertes.fr/pages/en/reference.php?id=113
 
<B>Potential edited summary write up on documentary:</B>
"The Franco-German television channel ARTE aired a documentary on fasting. The program examines the potential role to be played by fasting in the healthcare systems of industrialized countries, including in the treatment of diabetes, hypertension, obesity, and cancer, and as a way to reduce the potential overconsumption of pharmaceuticals. The film spotlights five major centers of fasting: In Germany, the film profiles the Buchinger Clinic in Überlingen, as well as the Department of Natural Medicine at the Charité University Hospital in Berlin. At the Centre National de Recherche Scientifique in Strasbourg, France, Professor Yvon Le Maho and his team investigate instinctive fasting in the animal kingdom."
 
<B>Original Write up on the documentary from one of the sources:</B>
"Fasting as medical therapy is now experiencing a revival thanks to the groundbreaking research by Professor Valter Longo in the areas of anti-aging and cancer therapy.
The Franco-German television channel ARTE aired an excellent scientific documentary on fasting. Produced by the renowned French documentary duo, Sylvie Gilman and Thierry Vincent de Lestrade, the program examines the potential role to be played by fasting in the healthcare systems of industrialized countries, including in the treatment of diabetes, hypertension, obesity, and cancer, and as a way to reduce the explosive overconsumption of pharmaceuticals.
In presenting fasting as a proven complementary therapy, the film spotlights five major centers of fasting science and therapy: In Germany, the film profiles the Buchinger Clinic in Überlingen, as well as the Department of Natural Medicine at the Charité University Hospital in Berlin. At the Buchinger Clinics in Überlingen and Marbella, more than 250,000 fasting therapies have been medically supervised in the last 60 years. The Buchinger Clinics are Europe’s largest clinics for therapeutic fasting and have profound experience in the medical applications of fasting. At the Centre National de Recherche Scientifique in Strasbourg, France, Professor Yvon Le Maho and his team use the latest technology to investigate instinctive fasting in the animal kingdom.
Hundreds of publications have shown that the ability to fast is a natural physiological adaptation of humans and animals to life on the planet Earth. The availability of food changes from winter to summer, and therefore a succession of eating and fasting periods is absolutely normal. Doctors and clinics in Russia have amassed extensive knowledge and experience in therapeutic fasting, including a wealth of scientific publications during the Soviet era that have never been translated and remain virtually unknown outside Russia. In the United States, there is a tradition of fasting in the alternative scene. "
 
* <B>"Eat, Fast and Live Longer" – (BBC Horizon Documentary)</B>
Michael Mosley has set himself a truly ambitious goal: he wants to live longer, stay younger and lose weight in the bargain. And he wants to make as few changes to his life as possible along the way. He discovers the powerful new science behind the ancient idea of fasting, and he thinks he's found a way of doing it that still allows him to enjoy his food. Michael tests out the science of fasting on himself - with life-changing results http://www.bbc.co.uk/programmes/b01lxyzc
 
* <B>some miscelaneous sources in media from the web:</B>
• Routine Periodic Fasting Is Good for Your Health, and Your Heart, Study Suggests, ScienceDaily (Apr. 3, 2011) http://www.sciencedaily.com/releases/2011/04/110403090259.htm
 
• Fasting Weakens Cancer in Mice http://www.sciencedaily.com/releases/2012/02/120208152254.htm
 
• Fasting could help fight cancer, By Roger Highfield, Science Editor http://www.telegraph.co.uk/science/science-news/3337872/Fasting-could-help-fight-cancer.html
 
• Fasting and cancer, Starving the Beast, The Economist, Feb 9th 2012, 22:02 by T.C. http://www.economist.com/blogs/babbage/2012/02/fasting-and-cancer
 
• Fasting can help protect against brain diseases, scientists say: Claim that giving up almost all food for one or two days a week can counteract impact of Alzheimer's and Parkinson's http://www.guardian.co.uk/society/2012/feb/18/fasting-protect-brain-diseases-scientists
 
* <B>A few medical sources to sort through for potential inclusion of some of the more credible ones</B> (some will be less credible or less current than others or some are more on caloric restriction and not actual fasting so perhaps to be sorted seperately into caloric restriction wikipedia page if any wikipeida community wish to submit):
 
1. Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy. Lee C, Raffaghello L, Brandhorst S, Safdie FM, Bianchi G, Martin-Montalvo A, Pistoia V, Wei M, Hwang S, Merlino A, Emionite L, de Cabo R, Longo VD. Andrus Gerontology Center, Department of Biological Sciences, Norris Cancer Center, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089-0191, USA. http://www.ncbi.nlm.nih.gov/pubmed/22323820 Abstract: Short-term starvation (or fasting) protects normal cells, mice, and potentially humans from the harmful side effects of a variety of chemotherapy drugs. Here, we show that treatment with starvation conditions sensitized yeast cells (Saccharomyces cerevisiae) expressing the oncogene-like RAS2(val19) to oxidative stress and 15 of 17 mammalian cancer cell lines to chemotherapeutic agents. Cycles of starvation were as effective as chemotherapeutic agents in delaying progression of different tumors and increased the effectiveness of these drugs against melanoma, glioma, and breast cancer cells. In mouse models of neuroblastoma, fasting cycles plus chemotherapy drugs--but not either treatment alone--resulted in long-term cancer-free survival. In 4T1 breast cancer cells, short-term starvation resulted in increased phosphorylation of the stress-sensitizing Akt and S6 kinases, increased oxidative stress, caspase-3 cleavage, DNA damage, and apoptosis. These studies suggest that multiple cycles of fasting promote differential stress sensitization in a wide range of tumors and could potentially replace or augment the efficacy of certain chemotherapy drugs in the treatment of various cancers.
 
2. Fasting and cancer treatment in humans: A case series report. Fernando M. Safdie,1,6 Tanya Dorff,2,3,6 David Quinn,2,3 Luigi Fontana,4 Min Wei,1 Changhan Lee,1 Pinchas Cohen,5 and Valter D. Longo1 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815756/ Abstract: Short-term fasting (48 hours) was shown to be effective in protecting normal cells and mice but not cancer cells against high dose chemotherapy, termed Differential Stress Resistance (DSR), but the feasibility and effect of fasting in cancer patients undergoing chemotherapy is unknown. Here we describe 10 cases in which patients diagnosed with a variety of malignancies had voluntarily fasted prior to (48-140 hours) and/or following (5-56 hours) chemotherapy. None of these patients, who received an average of 4 cycles of various chemotherapy drugs in combination with fasting, reported significant side effects caused by the fasting itself other than hunger and lightheadedness. Chemotherapy associated toxicity was graded according to the Common Terminology Criteria for Adverse Events (CTCAE) of the National Cancer Institute (NCI). The six patients who underwent chemotherapy with or without fasting reported a reduction in fatigue, weakness, and gastrointestinal side effects while fasting. In those patients whose cancer progression could be assessed, fasting did not prevent the chemotherapy-induced reduction of tumor volume or tumor markers. Although the 10 cases presented here suggest that fasting in combination with chemotherapy is feasible, safe, and has the potential to ameliorate side effects caused by chemotherapies, they are not meant to establish practice guidelines for patients undergoing chemotherapy. Only controlled-randomized clinical trials will determine the effect of fasting on clinical outcomes including quality of life and therapeutic index.
 
3. ‘Short-term therapeutic fasting (7 days) in the treatment of chronic pain and fatigue syndromes--well-being and side effects with and without mineral supplements’ - Michalsen A, Weidenhammer W, Melchart D, Langhorst J, Saha J, Dobos G. Department of Internal Medicine V and Integrative Medicine, Kliniken Essen Mitte, Am Deimelsberg 34 a, 45276 Essen, Germany. 2002 http://www.ncbi.nlm.nih.gov/pubmed/12232494
 
4. ‘The short-term (7 days) effects of fasting on the neuroendocrine system in patients with chronic pain syndromes.’ - Michalsen A, Schneider S, Rodenbeck A, Lüdtke R, Huether G, Dobos GJ. Department of Internal Medicine V and Integrative Medicine, Kliniken Essen Mitte, Am Deimelsberg 34 a, 45276 Essen, Germany. 2003 http://www.ncbi.nlm.nih.gov/pubmed/12608732
 
5. 2010 / CellCycle / Fasting and differential chemotherapy protection in patients / Rafaghello, Prof. Valter Longo, et al./ DOI: 10.4161/cc.9.22.13954
 
6. 2010 / Trends in Pharmacological Sciences / Calorie restriction and cancer prevention: metabolic and molecular mechanisms / Prof Valter D. Longo and Luigi Fontana / DOI: 10.1016/j.tips.2009.11.004
 
7. 2007 / PNAS / Starvation‐dependent differential stress resistance protects normal but not cancer against high‐dose chemotherapy / Lizzia Raffaghello, Prof. Valter Longo, et al. / DOI: 10.1073"pnas.0708100105
 
8. 2011 / Oncogene Research / Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients / Changhan Lee and Prof. Valter Longo / DOI: 10.1038/onc.2011.91
 
9. ‘Medically supervised water-only fasting in the treatment of hypertension.’ Goldhamer A, Lisle D, Parpia B, Anderson SV, Campbell TC. Center for Conservative Therapy, Penngrove, Calif, USA. 2002 http://www.ncbi.nlm.nih.gov/pubmed/11416824
 
10. ‘Medically supervised water-only fasting in the treatment of borderline hypertension.; - Goldhamer AC, Lisle DJ, Sultana P, Anderson SV, Parpia B, Hughes B, Campbell TC. TrueNorth Health Center, Rohnert Park, CA 2002 http://www.ncbi.nlm.nih.gov/pubmed/12470446
 
11. ‘Prolonged fasting (7-21 days) as a method of mood enhancement in chronic pain syndromes: a review of clinical evidence and mechanisms.’ - Michalsen A. Immanuel Hospital Berlin, Department of Internal and Complementary Medicine, Institute of Social Medicine, Epidemiology and Health Economics, Charité-University Medical Centre, Germany. 2010 http://www.ncbi.nlm.nih.gov/pubmed/20425196 Abstract: Periods of deliberate fasting with restriction to intake of solid food are practiced worldwide, mostly based on a traditional, cultural, or religious background. Recent evidence from clinical trials shows that medically supervised modified fasting (200-500 kcal nutritional intake/day) with periods from 7 to 21 days is efficacious in the treatment of rheumatic diseases and chronic pain syndromes. Here, fasting is frequently accompanied by increased alertness and mood enhancement. The beneficial claims of fasting are supported by experimental research, which has found fasting to be associated with increased brain availability of serotonin, endogenous opioids, and endocannabinoids. Fasting-induced neuroendocrine activation and mild cellular stress response with increased production of neurotrophic factors may also contribute to the mood enhancement of fasting. Fasting treatments may be useful as an adjunctive therapeutic approach in chronic pain patients. The mood-enhancing and pain-relieving effect of therapeutic fasting should be further evaluated in randomized clinical trials.
 
12. ‘Caloric restriction in primates and relevance to humans.’ - Roth GS, Ingram DK, Lane MA. Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA. 2001 http://www.ncbi.nlm.nih.gov/pubmed/11795522 Abstract: Dietary caloric restriction (CR) is the only intervention conclusively and reproducibly shown to slow aging and maintain health and vitality in mammals. Although this paradigm has been known for over 60 years, its precise biological mechanisms and applicability to humans remain unknown. We began addressing the latter question in 1987 with the first controlled study of CR in primates (rhesus and squirrel monkeys, which are evolutionarily much closer to humans than the rodents most frequently employed in CR studies). To date, our results strongly suggest that the same beneficial "antiaging" and/or "antidisease" effects observed in CR rodents also occur in primates. These include lower plasma insulin levels and greater sensitivity; lower body temperatures; reduced cholesterol, triglycerides, blood pressure, and arterial stiffness; elevated HDL; and slower age-related decline in circulating levels of DHEAS. Collectively, these biomarkers suggest that CR primates will be less likely to incur diabetes, cardiovascular problems, and other age-related diseases and may in fact be aging more slowly than fully fed counterparts. Despite these very encouraging results, it is unlikely that most humans would be willing to maintain a 30% reduced diet for the bulk of their adult life span, even if it meant more healthy years.
 
13. ‘The impact of religious fasting on human health.’ Trepanowski JF, Bloomer RJ. Cardiorespiratory/Metabolic Laboratory, The University of Memphis, Memphis, TN 38152, USA. http://www.ncbi.nlm.nih.gov/pubmed/21092212 Abstract: Greek Orthodox Christians fast for a total of 180 - 200 days each year, and their main fasting periods are the Nativity Fast (40 days prior to Christmas), Lent (48 days prior to Easter), and the Assumption (15 days in August). Some of the more favorable effects of these fasts include the lowering of body mass, total cholesterol, LDL-C, and the LDL-C/HDL-C ratio. The Biblical-based Daniel Fast prohibits the consumption of animal products, refined carbohydrates, food additives, preservatives, sweeteners, flavorings, caffeine, and alcohol. It is most commonly partaken for 21 days, although fasts of 10 and 40 days have been observed. Our initial investigation of the Daniel Fast noted favorable effects on several health-related outcomes, including: blood pressure, blood lipids, insulin sensitivity, and biomarkers of oxidative stress. This review summarizes the health-specific effects of these fasts and provides suggestions for future research.
 
14. ‘The Effects of Caloric Restriction on Health and Longevity.’ Green JL, Sawaya FJ, Dollar AL. Emory University, 49 Jesse Hill Jr Drive SE, Atlanta, GA, 30303, USA 2011 Abstract: OPINION STATEMENT: There is increasing evidence that restricting caloric intake may have considerable health benefits in humans. Significant evidence in non-primate animals demonstrates that caloric restriction increases average and maximal life span. However, historically, caloric intake reduction in humans has been involuntary and accompanied by poverty, malnutrition, poor sanitation, and a lack of modern health care. As a result, caloric restriction in people typically has been accompanied by a reduction of both average and maximal life span. Conversely, improvements in standards of living usually are accompanied by an increased food supply and resultant improved health and longevity. The majority of the world is now in a new era where an abundance of caloric intake and its associated obesity are causing widespread chronic illness and premature death. What would happen if one were to institute caloric restriction with high-quality nutrition within an environment of modern sanitation and health care? This review argues that improved health and improved average life span would quite likely result. A lengthening of maximal human life span with this combination is perhaps possible but by no means certain.
 
15. A.J.Carlson and F. Hoelzel, “Nutrition, Senescence and Rejuvenescence”. Public Health Reports Vol.67 No.2. February 1952 Chicago.
 
16. H.L.Taylor, “American Journal of Physiology”. pp143-148 1945.
 
17. A.J.Carlson and F. Hoelzel, “Apparent Prolongation of Lifespan of Rats by Intermittent Fasting”. Journal of Nutrition, 31:363 1946.
 
18. Sergius Morgulis, “Fasting and Undernutrition”. University of Nebraska, E.P. Dutton, New York 1923.
 
19. A.J.Carlson, “The Control of Hunger in Health and Disease”. University of Chicago 1916.
 
20. Margaret M. Kunde, “The After Effects of Prolonged Fasting on the Basal Metabolic Rate”. Journal of Metabolic Research 1923, 3, 399 – 449.
 
21. R.H. Weindruch, J.A.Kristie, K.Cheney and R.L.Walford, “The Influence of Controlled Dietary Restriction on Immunologic Function and Ageing”. Federation Proceedings U.C.L.A. 389:2007 (1979)
 
22. ‘Caloric restriction in C57BL/6J mice mimics therapeutic fasting in humans.’ - Mahoney LB, Denny CA, Seyfried TN. Biology Department, Boston College, Chestnut Hill, MA, USA. 2006
 
23. ‘Clinical Aspects of the Ketogenic Diet’ - Adam L. Hartman, Eileen P. G. Vining, The John M. Freeman Pediatric Epilepsy Center, Johns Hopkins Medical Institutions, Baltimore, Maryland U.S.A. http://onlinelibrary.wiley.com/doi/10.1111/j.1528-1167.2007.00914.x/full
 
24. ‘Fasting increases the in vivo gene delivery of AAV vectors.’ - Moulay G, Scherman D, Kichler A., Genethon, Evry, France. http://www.ncbi.nlm.nih.gov/pubmed/21207763
 
25. ‘Greek Orthodox fasting rituals: a hidden characteristic of the Mediterranean diet of Crete.’ Sarri KO, Linardakis MK, Bervanaki FN, Tzanakis NE, Kafatos AG. Department of Social Medicine, University of Crete, School of Medicine, PO Box 2208, Iraklion 71003, Greece. 2004 http://www.ncbi.nlm.nih.gov/pubmed/15333159
 
26. ‘Incorporation of fasting therapy in an integrative medicine ward: evaluation of outcome, safety, and effects on lifestyle adherence in a large prospective cohort study.’ - Michalsen A, Hoffmann B, Moebus S, Bäcker M, Langhorst J, Dobos GJ. Department of Integrative and Internal Medicine V, Kliniken Essen-Mitte, and Complementary and Integrative Medicine of the Alfred Krupp von Bohlen und Halbach Foundation, University Duisburg-Essen, Essen, Germany. 2005 http://www.ncbi.nlm.nih.gov/pubmed/16131283
27. Short-term dietary restriction and fasting precondition against ischemia reperfusion injury in mice.’ Mitchell JR, Verweij M, Brand K, van de Ven M, Goemaere N, van den Engel S, Chu T, Forrer F, Müller C, de Jong M, van IJcken W, IJzermans JN, Hoeijmakers JH, de Bruin RW. Department of Genetics, Erasmus Medical Center, Cancer Genomics Center, Dr. Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands. 2010 http://www.ncbi.nlm.nih.gov/pubmed/19878145
 
28. ‘A trial of fasting cure for PCB-poisoned patients in Taiwan.’ 1984 Imamura M, Tung TC. http://www.ncbi.nlm.nih.gov/pubmed/6422746
 
29. ‘Brain Metabolism during Fasting’ O. E. Owen, A. P. Morgan, H. G. Kemp, J. M. Sullivan, M. G. Herrera, and G. F. Cahill, Jr., Elliott P. Joslin Research Laboratory, Department of Medicine, Harvard Medical School, the Cardiovascular Unit, the Peter Bent Brigham Hospital, and the Diabetes Foundation, Inc., Boston, Massachusetts 1967 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC292907/?page=6
 
30. ‘Brief case reports of medically supervised, water-only fasting associated with remission of autoimmune disease.’ Fuhrman J, Sarter B, Calabro DJ. Hunterdon Medical Center, Flemington, NJ, USA. 2002 http://www.ncbi.nlm.nih.gov/pubmed/12126162
 
31. There is also a highly dubious case in India of a man called Prahlad Jani whom claims to have lived without not just food but also water for years. Observation studies of Jani have been conducted, one in 2003 and one in 2010, both involving Sudhir Shah, a neurologist at the Sterling Hospitals in Ahmedabad, India. http://en.wikipedia.org/wiki/Prahlad_Jani
 
[[User:SpringSummerAutumn|SpringSummerAutumn]] ([[User talk:SpringSummerAutumn|talk]]) 14:38, 20 November 2012 (UTC)