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During the [[First World War]] Lewis worked at the [[Military Heart Hospital]] in [[Hampstead]] and was appointed to the first full-time clinical research post in Britain, at the Medical Research Committee (later [[Medical Research Council (United Kingdom)|Medical Research Council]]). He directed a study of the condition known as "soldier's heart" and, having established it was not a cardiological problem, renamed it the "[[effort syndrome]]".<ref name="DNB" /> In 1918 he wrote the monograph ''The Soldier's Heart and the Effort Syndrome''. He devised remedial exercises that allowed many soldiers suffering from the condition to return to duty and was appointed honorary consulting physician to the [[Ministry of Pensions]] in April 1919, and for this work he was appointed [[Commander of the Order of the British Empire]] (CBE) in January 1920<ref>{{LondonGazette |issue=31760 |date=27 January 1920|startpage=1237|supp=yes}}</ref> and was [[Knight Bachelor|knighted]] in the [[1921 Birthday Honours]].<ref>{{LondonGazette|issue=32346|supp=yes|startpage=4531|endpage=|date=4 June 1921}}</ref>
After the war
[[File:Electrocardiograph circa 1930.jpg|thumb|His Electocardiograph machine circa 1930 with wheels so it could be taken onto wards. His machine is now on display at the Science Museum in London.]]
In 1930
Lewis suffered a [[myocardial infarction]] at the age of 45 and gave up his 70-cigarette-a-day habit, being one of the first to realise that smoking damaged the blood vessels.<ref name="DNB" /> He died from [[coronary heart disease]] at his home at [[Loudwater, Hertfordshire]] on 17 March 1945.
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