Glutathione peroxidase 7: Difference between revisions

GPX7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2P31
Identifiers
Aliases	GPX7, CL683, GPX6, GPx-7, GSHPx-7, NPGPx, glutathione peroxidase 7
External IDs	OMIM: 615784; MGI: 1914555; HomoloGene: 128491; GeneCards: GPX7; OMA:GPX7 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	52,609,051 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	108,264,158 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; cartilage tissue; ; ganglionic eminence; ; periodontal fiber; ; gallbladder; ; granulocyte; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; anterior pituitary; ; left uterine tube;
	Top expressed in
	external naris; ; calvaria; ; dermis; ; intervertebral disc; ; efferent ductule; ; cervical vertebral column; ; external carotid artery; ; fossa; ; endocardial cushion; ; thoracic vertebral column;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity; glutathione peroxidase activity; catalase activity; protein binding; peroxidase activity;
Cellular component	extracellular region; endoplasmic reticulum lumen; endoplasmic reticulum;
Biological process	response to oxidative stress; cellular oxidant detoxification; cellular response to oxidative stress;
	Sources:Amigo / QuickGO
Orthologs
	2882
	67305
	ENSG00000116157
	ENSMUSG00000028597
	Q96SL4
	Q99LJ6
	NM_015696
	NM_024198
	NP_056511
	NP_077160
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 18:17, 23 September 2024

Glutathione peroxidase 7 is an enzyme that in humans is encoded by the GPX7 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116157 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028597 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Utomo A, Jiang X, Furuta S, Yun J, Levin DS, Wang YC, Desai KV, Green JE, Chen PL, Lee WH (Oct 2004). "Identification of a novel putative non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase (NPGPx) essential for alleviating oxidative stress generated from polyunsaturated fatty acids in breast cancer cells". J Biol Chem. 279 (42): 43522–9. doi:10.1074/jbc.M407141200. PMID 15294905.
^ "Entrez Gene: GPX7 glutathione peroxidase 7".

Opalenik SR, Ding Q, Mallery SR, Thompson JA (1998). "Glutathione depletion associated with the HIV-1 TAT protein mediates the extracellular appearance of acidic fibroblast growth factor". Arch. Biochem. Biophys. 351 (1): 17–26. doi:10.1006/abbi.1997.0566. PMID 9501919.
Choi J, Liu RM, Kundu RK, et al. (2000). "Molecular mechanism of decreased glutathione content in human immunodeficiency virus type 1 Tat-transgenic mice". J. Biol. Chem. 275 (5): 3693–8. doi:10.1074/jbc.275.5.3693. PMID 10652368.
Richard MJ, Guiraud P, Didier C, et al. (2001). "Human immunodeficiency virus type 1 Tat protein impairs selenoglutathione peroxidase expression and activity by a mechanism independent of cellular selenium uptake: consequences on cellular resistance to UV-A radiation". Arch. Biochem. Biophys. 386 (2): 213–20. doi:10.1006/abbi.2000.2197. PMID 11368344.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Price TO, Ercal N, Nakaoke R, Banks WA (2005). "HIV-1 viral proteins gp120 and Tat induce oxidative stress in brain endothelial cells". Brain Res. 1045 (1–2): 57–63. doi:10.1016/j.brainres.2005.03.031. PMID 15910762. S2CID 7362454.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Glutathione peroxidase 7

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116157 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028597 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15294905-5] Utomo A, Jiang X, Furuta S, Yun J, Levin DS, Wang YC, Desai KV, Green JE, Chen PL, Lee WH (Oct 2004). "Identification of a novel putative non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase (NPGPx) essential for alleviating oxidative stress generated from polyunsaturated fatty acids in breast cancer cells". J Biol Chem. 279 (42): 43522–9. doi:10.1074/jbc.M407141200. PMID 15294905.

[entrez-6] "Entrez Gene: GPX7 glutathione peroxidase 7".

[1]

[2]

[3]

[4]

[5]

[6]

@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
-{{PBB|geneid=2882}}
+{{Infobox_gene}}
-'''Glutathione peroxidase 7''' is an [[enzyme]] that in humans is encoded by the ''GPX7'' [[gene]].<ref name="pmid15294905">{{cite journal | author = Utomo A, Jiang X, Furuta S, Yun J, Levin DS, Wang YC, Desai KV, Green JE, Chen PL, Lee WH | title = Identification of a novel putative non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase (NPGPx) essential for alleviating oxidative stress generated from polyunsaturated fatty acids in breast cancer cells | journal = J Biol Chem | volume = 279 | issue = 42 | pages = 43522–9 |date=Oct 2004 | pmid = 15294905 | pmc =  | doi = 10.1074/jbc.M407141200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GPX7 glutathione peroxidase 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2882| accessdate = }}</ref>
+'''Glutathione peroxidase 7''' is an [[enzyme]] that in humans is encoded by the ''GPX7'' [[gene]].<ref name="pmid15294905">{{cite journal |vauthors=Utomo A, Jiang X, Furuta S, Yun J, Levin DS, Wang YC, Desai KV, Green JE, Chen PL, Lee WH | title = Identification of a novel putative non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase (NPGPx) essential for alleviating oxidative stress generated from polyunsaturated fatty acids in breast cancer cells | journal = J Biol Chem | volume = 279 | issue = 42 | pages = 43522–9 |date=Oct 2004 | pmid = 15294905 | doi = 10.1074/jbc.M407141200 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GPX7 glutathione peroxidase 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2882}}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
-| section_title =
-| summary_text =
-}}
 ==References==
 {{reflist}}
 ==Further reading==
 {{refbegin | 2}}
+*{{cite journal  |vauthors=Opalenik SR, Ding Q, Mallery SR, Thompson JA |title=Glutathione depletion associated with the HIV-1 TAT protein mediates the extracellular appearance of acidic fibroblast growth factor. |journal=Arch. Biochem. Biophys. |volume=351 |issue= 1 |pages= 17–26 |year= 1998 |pmid= 9501919 |doi= 10.1006/abbi.1997.0566 }}
-{{PBB_Further_reading
+*{{cite journal   |vauthors=Choi J, Liu RM, Kundu RK, etal |title=Molecular mechanism of decreased glutathione content in human immunodeficiency virus type 1 Tat-transgenic mice. |journal=J. Biol. Chem. |volume=275 |issue= 5 |pages= 3693–8 |year= 2000 |pmid= 10652368 |doi=10.1074/jbc.275.5.3693  |doi-access=free }}
-| citations =
-*{{cite journal  | author=Opalenik SR, Ding Q, Mallery SR, Thompson JA |title=Glutathione depletion associated with the HIV-1 TAT protein mediates the extracellular appearance of acidic fibroblast growth factor. |journal=Arch. Biochem. Biophys. |volume=351 |issue= 1 |pages= 17–26 |year= 1998 |pmid= 9501919 |doi= 10.1006/abbi.1997.0566 }}
+*{{cite journal   |vauthors=Richard MJ, Guiraud P, Didier C, etal |title=Human immunodeficiency virus type 1 Tat protein impairs selenoglutathione peroxidase expression and activity by a mechanism independent of cellular selenium uptake: consequences on cellular resistance to UV-A radiation. |journal=Arch. Biochem. Biophys. |volume=386 |issue= 2 |pages= 213–20 |year= 2001 |pmid= 11368344 |doi= 10.1006/abbi.2000.2197 }}
-*{{cite journal  | author=Choi J, Liu RM, Kundu RK, ''et al.'' |title=Molecular mechanism of decreased glutathione content in human immunodeficiency virus type 1 Tat-transgenic mice. |journal=J. Biol. Chem. |volume=275 |issue= 5 |pages= 3693–8 |year= 2000 |pmid= 10652368 |doi=10.1074/jbc.275.5.3693  }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
-*{{cite journal  | author=Richard MJ, Guiraud P, Didier C, ''et al.'' |title=Human immunodeficiency virus type 1 Tat protein impairs selenoglutathione peroxidase expression and activity by a mechanism independent of cellular selenium uptake: consequences on cellular resistance to UV-A radiation. |journal=Arch. Biochem. Biophys. |volume=386 |issue= 2 |pages= 213–20 |year= 2001 |pmid= 11368344 |doi= 10.1006/abbi.2000.2197 }}
+*{{cite journal   |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003  | pmc=403697 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
+*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
-*{{cite journal  | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003  | pmc=403697 }}
+*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal  |vauthors=Price TO, Ercal N, Nakaoke R, Banks WA |title=HIV-1 viral proteins gp120 and Tat induce oxidative stress in brain endothelial cells. |journal=Brain Res. |volume=1045 |issue= 1–2 |pages= 57–63 |year= 2005 |pmid= 15910762 |doi= 10.1016/j.brainres.2005.03.031 |s2cid=7362454 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
+*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }}
-*{{cite journal  | author=Price TO, Ercal N, Nakaoke R, Banks WA |title=HIV-1 viral proteins gp120 and Tat induce oxidative stress in brain endothelial cells. |journal=Brain Res. |volume=1045 |issue= 1–2 |pages= 57–63 |year= 2005 |pmid= 15910762 |doi= 10.1016/j.brainres.2005.03.031 }}
+*{{cite journal   |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |bibcode=2006Natur.441..315G |doi-access= free }}
-*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
+*{{cite journal   |vauthors=Lim J, Hao T, Shaw C, etal |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 |s2cid=13709685 |doi-access=free }}
-*{{cite journal  | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
-*{{cite journal  | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
-}}
 {{refend}}
+== External links ==
-{{gene-1-stub}}
+* [https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/Q96SL4 PDBe-KB] provides an overview of all the structure information available in the PDB for Human Glutathione peroxidase 7
 {{PDB Gallery|geneid=2882}}
 {{Peroxidases}}
+{{Enzymes}}
+{{Portal bar|Biology|border=no}}
 [[Category:EC 1.11.1]]
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{gene-1-stub}}
-{{PBB_Controls
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}

v t e Oxidoreductases: peroxidases (EC 1.11)
1.11.1.1-14	NADH peroxidase NADPH peroxidase Fatty-acid peroxidase Catalase Cytochrome c peroxidase Eosinophil peroxidase Glutathione peroxidase GPX 1 2 3 4 5 6 7 8 Horseradish peroxidase Lactoperoxidase Myeloperoxidase Thyroid peroxidase Deiodinase Iodothyronine deiodinase Iodotyrosine deiodinase
1.11.1.15 (peroxiredoxin)	1 2 3 4 5 6

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)