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References:
•Naschitz JE, Rosner I, Rozenbaum M, Naschitz S, Musafia-Priselac R, Shaviv N, Fields M, Isseroff H, Zuckerman E, Yeshurun D, Sabo E. The head-up tilt test with haemodynamic instability score in diagnosing chronic fatigue syndrome. Q J Med 2003; 96:133–42.
•Naschitz JE, Rosner I, Rozenbaum M, Naschitz S, Musafia-Priselac R, Shaviv N, Fields M, Isseroff H, Zuckerman E, Yeshurun D, Sabo E. The head-up tilt test with haemodynamic instability score in diagnosing chronic fatigue syndrome. Q J Med 2003; 96:133–42.
•Baschetti R. Chronic fatigue syndrome, decreased exercise capacity, and adrenal insufficiency. Arch Intern Med 2001; 161:1558–9.
•Baschetti R. Chronic fatigue syndrome, decreased exercise capacity, and adrenal insufficiency. Arch Intern Med 2001; 161:1558–9.

Revision as of 07:11, 29 March 2011

Possible relations to Addison's Disease

It has been proposed by some specialists that Chronic Fatigue Syndrome is a form of Addison's disease (referred to as adrenal insufficiency or hypoadrenalism). The following evidence has been presented (Jefferies 1994; Baschetti 1999; Jeffcoate 1999; Baschetti 2000): 'In view of the 36 features shared by Chronic Fatigue Syndrome and Addison’s disease, including hypocortisolism and a host of neuropsychological complaintsCite error: The <ref> tag has too many names (see the help page). and investigations of the effects of hydrocortisone plus fludrocortisone in the treatment of CFS’ [1][2][3][4][5][6]Cite error: The <ref> tag has too many names (see the help page). [7]

• Many of the symptoms of CFS overlap those of Addison's disease (adrenal failure). • Improvement in CFS patients has occurred after supplementation with mineralocorticoids (fludrocortisone), low-dose hydrocortisone (cortisol).

Refrences

  1. ^ Cleare AJ, Heap E, Malhi GS, Wessely S, O’Keane V, Miell J. 1999 Low-dose hydrocortisone in chronic fatigue syndrome: a randomised crossover trial. Lancet. 353:455–458.
  2. ^ Role of the Endocrine System in Chronic Fatigue Syndrome, Pro Health, ProHealth.com [1]
  3. ^ 'Similarity of symptoms in chronic fatigue syndrome and Addison's disease' European Journal of Clinical Investigation Volume 27, Issue 12, page 1062, December 1997 [2]
  4. ^ Chronic Fatigue Syndrome for Dummies By Susan R. Lisman, Karla Dougherty, Chapter 3, page 49
  5. ^ The Journal of Clinical Endocrinology & Metabolism Vol. 84, No. 6 2263-2264 1999, Investigations of Hydrocortisone and Fludrocortisone in the Treatment of Chronic Fatigue Syndrome, Riccardo Baschetti, M.D. [3]
  6. ^ Baschetti R. Chronic fatigue syndrome: a form of Addison’s disease. J Intern Med 2000; 247:737–9.
  7. ^ Naschitz JE, Rosner I, Rozenbaum M, Naschitz S, Musafia-Priselac R, Shaviv N, Fields M, Isseroff H, Zuckerman E, Yeshurun D, Sabo E. The head-up tilt test with haemodynamic instability score in diagnosing chronic fatigue syndrome. Q J Med 2003; 96:133–42.


•Naschitz JE, Rosner I, Rozenbaum M, Naschitz S, Musafia-Priselac R, Shaviv N, Fields M, Isseroff H, Zuckerman E, Yeshurun D, Sabo E. The head-up tilt test with haemodynamic instability score in diagnosing chronic fatigue syndrome. Q J Med 2003; 96:133–42. •Baschetti R. Chronic fatigue syndrome, decreased exercise capacity, and adrenal insufficiency. Arch Intern Med 2001; 161:1558–9. •Kuratsune H, Yamaguti K, Sawada M, Kodate S, Machii T, Kanakura Y, Kitani T. Dehydroepiandrosterone sulfate deficiency in chronic fatigue syndrome. Int J Mol Med 1998; 1:143–6. •Hunt PJ, Gurnell EM, Huppert FA, Richards C, Prevost AT, Wass JA, Herbert J, Chatterjee VK. Improvement in mood and fatigue after dehydroepiandrosterone replacement in Addison’s disease in a randomized, double blind trial. J Clin Endocrinol Metab 2000; 85:4650–6.