Opioidergic: Difference between revisions
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'''Opioidergic''', or simply '''opioid''', means "related to [[opioid]]s". |
'''Opioidergic''', or simply '''opioid''', means "related to [[opioid]]s". |
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An '''opioidergic |
An '''opioidergic agent''', is a chemical which functions to directly modulate the [[opioid peptide|opioid neuropeptide]] systems (i.e., [[endorphin]], [[enkephalin]], [[dynorphin]], [[nociceptin]]) in the body or brain. Examples include [[opioid]] [[analgesic]]s such as [[morphine]] and [[opioid antagonist]]s such as [[naloxone]]. Opioidergics also comprise [[allosteric modulator]]s and [[enzyme]] affecting agents like [[enkephalinase inhibitor]]s. |
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==Allosteric modulators== |
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[[File:BMS-986121.png|thumb|right|210px|BMS-986121]] |
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* BMS-986121: μ-PAM<ref name="pmid23754417">{{cite journal |author=Burford NT, Clark MJ, Wehrman TS, ''et al.'' |title=Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=110 |issue=26 |pages=10830–5 |year=2013 |month=June |pmid=23754417 |pmc=3696790 |doi=10.1073/pnas.1300393110 |url=}}</ref> |
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* BMS-986122: μ-PAM<ref name="pmid23754417"/> |
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* [[Cannabidiol]]<ref name="PMID16489449">{{cite journal | author = Kathmann M, Flau K, Redmer A, Tränkle C, Schlicker E | title = Cannabidiol is an allosteric modulator at mu- and delta-opioid receptors | journal = Naunyn Schmiedebergs Arch. Pharmacol. | volume = 372 | issue = 5 | pages = 354–61 | date = February 2006 | pmid = 16489449 | doi = 10.1007/s00210-006-0033-x }}</ref> |
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* [[Tetrahydrocannabinol]]<ref name="PMID16489449"/> |
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==See also== |
==See also== |
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Revision as of 14:38, 31 July 2014
Opioidergic, or simply opioid, means "related to opioids".
An opioidergic agent, is a chemical which functions to directly modulate the opioid neuropeptide systems (i.e., endorphin, enkephalin, dynorphin, nociceptin) in the body or brain. Examples include opioid analgesics such as morphine and opioid antagonists such as naloxone. Opioidergics also comprise allosteric modulators and enzyme affecting agents like enkephalinase inhibitors.
Allosteric modulators
- BMS-986121: μ-PAM[1]
- BMS-986122: μ-PAM[1]
- Cannabidiol[2]
- Tetrahydrocannabinol[2]
See also
References
- ^ a b Burford NT, Clark MJ, Wehrman TS; et al. (2013). "Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor". Proc. Natl. Acad. Sci. U.S.A. 110 (26): 10830–5. doi:10.1073/pnas.1300393110. PMC 3696790. PMID 23754417.
{{cite journal}}: Explicit use of et al. in:|author=(help); Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ a b Kathmann M, Flau K, Redmer A, Tränkle C, Schlicker E (February 2006). "Cannabidiol is an allosteric modulator at mu- and delta-opioid receptors". Naunyn Schmiedebergs Arch. Pharmacol. 372 (5): 354–61. doi:10.1007/s00210-006-0033-x. PMID 16489449.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
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