GABA transporter: Difference between revisions
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'''GABA Transporters''' are part of the large family of neurotransmitters known as Sodium symporters, also known as solute carrier 6 (SLC6) which are Na+ concentration dependent. They are found in various regions of the brain in different cell types, such as neurons and astrocytes. These transporters are primarily responsible for the regulation of extracellular GABA concentration during basal and synaptic activity. There are present on the plasma membrane of neurons and glia which help define their function of regulation of GABA concentration. GABA transporter group consists of five different transporters: |
'''GABA Transporters''' are part of the large family of neurotransmitters known as Sodium symporters<ref>{{Cite journal|last=Scimemi|first=Annalisa|date=2014-06-17|title=Structure, function, and plasticity of GABA transporters|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060055/|journal=Frontiers in Cellular Neuroscience|volume=8|doi=10.3389/fncel.2014.00161|issn=1662-5102|pmc=PMC4060055|pmid=24987330}}</ref>, also known as solute carrier 6 (SLC6)<ref>{{Cite journal|last=Kinjo|first=Azusa|last2=Koito|first2=Tomoko|last3=Kawaguchi|first3=So|last4=Inoue|first4=Koji|date=2013-12-03|title=Evolutionary History of the GABA Transporter (GAT) Group Revealed by Marine Invertebrate GAT-1|url=https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0082410|journal=PLoS ONE|language=en|volume=8|issue=12|pages=e82410|doi=10.1371/journal.pone.0082410|issn=1932-6203|pmc=PMC3849432|pmid=24312660}}</ref> which are Na+ concentration dependent. They are found in various regions of the brain in different cell types, such as neurons and astrocytes. These transporters are primarily responsible for the regulation of extracellular GABA concentration during basal and synaptic activity. There are present on the plasma membrane of neurons and glia which help define their function of regulation of GABA concentration. GABA transporter group consists of five different transporters: |
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** [[GABA transporter type 1]] (GAT1; [[SLC6A1]]) |
** [[GABA transporter type 1]] (GAT1; [[SLC6A1]]) |
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Revision as of 18:06, 31 October 2018
GABA Transporters are part of the large family of neurotransmitters known as Sodium symporters[1], also known as solute carrier 6 (SLC6)[2] which are Na+ concentration dependent. They are found in various regions of the brain in different cell types, such as neurons and astrocytes. These transporters are primarily responsible for the regulation of extracellular GABA concentration during basal and synaptic activity. There are present on the plasma membrane of neurons and glia which help define their function of regulation of GABA concentration. GABA transporter group consists of five different transporters:
- GABA transporter type 1 (GAT1; SLC6A1)
- GABA transporter type 2 (GAT2; SLC6A13)
- GABA transporter type 3 (GAT3; SLC6A11)
- Betaine transporter (BGT1; SLC6A12)
- Vesicular GABA transporter (VGAT)
GAT1 and GAT3 are the major GABA transporters in the brain and spinal cord, expressed by both neurons and some astrocytes.[3] GAT2 and BGT1 are also expressed in the brain, but at low levels and mostly in the meninges. GAT2 also transports taurine, while BGT1 transports betaine. These two transporters are predominantly expressed in the liver, but are also found in the kidneys and, as mentioned above, in the meninges.[3]
References
- ^ Scimemi, Annalisa (2014-06-17). "Structure, function, and plasticity of GABA transporters". Frontiers in Cellular Neuroscience. 8. doi:10.3389/fncel.2014.00161. ISSN 1662-5102. PMC 4060055. PMID 24987330.
{{cite journal}}: CS1 maint: PMC format (link) CS1 maint: unflagged free DOI (link) - ^ Kinjo, Azusa; Koito, Tomoko; Kawaguchi, So; Inoue, Koji (2013-12-03). "Evolutionary History of the GABA Transporter (GAT) Group Revealed by Marine Invertebrate GAT-1". PLoS ONE. 8 (12): e82410. doi:10.1371/journal.pone.0082410. ISSN 1932-6203. PMC 3849432. PMID 24312660.
{{cite journal}}: CS1 maint: PMC format (link) CS1 maint: unflagged free DOI (link) - ^ a b Zhou Y, Danbolt NC (2013). "GABA and Glutamate Transporters in Brain". Front Endocrinol (Lausanne). 4: 165. doi:10.3389/fendo.2013.00165. PMC 3822327. PMID 24273530.
{{cite journal}}: CS1 maint: unflagged free DOI (link)
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