Opioidergic
An opioidergic agent (or drug) is a chemical which functions to directly modulate the opioid neuropeptide systems (i.e., endorphin, enkephalin, dynorphin, nociceptin) in the body or brain. Examples include opioid analgesics such as morphine and opioid antagonists such as naloxone. Opioidergics also comprise allosteric modulators and enzyme affecting agents like enkephalinase inhibitors.
Allosteric modulators
- BMS-986121: μ-PAM[1]
- BMS-986122: μ-PAM[1]
- Cannabidiol[2]
- Tetrahydrocannabinol[2]
- Sodium (Na+) [3]
See also
- Adenosinergic
- Adrenergic
- Cannabinoidergic
- Cholinergic
- Dopaminergic
- GABAergic
- GHBergic
- Glycinergic
- Histaminergic
- Melatonergic
- Monoaminergic
- Serotonergic
- Sigmaergic
References
- ^ a b Burford NT, Clark MJ, Wehrman TS; et al. (June 2013). "Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor". Proc. Natl. Acad. Sci. U.S.A. 110 (26): 10830–5. doi:10.1073/pnas.1300393110. PMC 3696790. PMID 23754417.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - ^ a b Kathmann M, Flau K, Redmer A, Tränkle C, Schlicker E (February 2006). "Cannabidiol is an allosteric modulator at mu- and delta-opioid receptors". Naunyn Schmiedebergs Arch. Pharmacol. 372 (5): 354–61. doi:10.1007/s00210-006-0033-x. PMID 16489449.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Shang Y, LeRouzic V, Schneider S, Bisignano P, Pasternak GW, Filizola M (2014). "Mechanistic insights into the allosteric modulation of opioid receptors by sodium ions". Biochemistry. 53 (31): 5140–9. doi:10.1021/bi5006915. PMID 25073009.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
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