This app calculates pharmacokinetic parameters from entered plasma concentrations for up to 48 subjects.

Noncompartmental pharmacokinetics is typically used to analyze data from small animal studies during the lead optimization phase of drug discovery. These studies are used to help predict human dosing and plan safety studies.

(The following instructions apply to Posix/bash. Windows users should check here.)

First, clone this repository and open a terminal inside the root folder.

Create and activate a new virtual environment (recommended) by running the following:

python3 -m venv myvenv

source myvenv/bin/activate

Install the requirements:

pip install -r requirements.txt

Run the app:

python app.py

Open a browser at http://127.0.0.1:8050

• AUC values are calculated using the trapezoid rule on non-logged concentrations.
• The AUC calculation includes t=0, even if no concentration is entered, in which case the concentration is assumed to be zero.
• The terminal elimination rate, used to determine t_1/2 and AUC_0-inf, is calculated from the final three time points.