This app calculates pharmacokinetic parameters from entered plasma concentrations for up to 48 subjects.

Noncompartmental pharmacokinetics is typically used to analyze data from small animal studies during the lead optimization phase of drug discovery. These studies are used to help predict human dosing and plan safety studies.

To run this app first clone repository and then open a terminal to the app folder.

git clone https://github.com/plotly/dash-sample-apps.git
cd dash-sample-apps/apps/dashr-pk-calc

Install the requirements:

Rscript init.R

Run the app:

Rscript app.R

You can run the app on your browser at http://127.0.0.1:8050

• AUC values are calculated using the trapezoid rule on non-logged concentrations.
• The AUC calculation includes t=0, even if no concentration is entered, in which case the concentration is assumed to be zero.
• The terminal elimination rate, used to determine t_1/2 and AUC_0-inf, is calculated from the final three time points.

To learn more about Dash, please visit documentation.