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DESCRIPTION
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Package: martini
Type: Package
Title: GWAS Incorporating Networks
Version: 1.19.0
Authors@R: c(person("Hector", "Climente-Gonzalez",
email = "[email protected]",
role = c("aut", "cre"),
comment = c(ORCID = "0000-0002-3030-7471")),
person("Chloe-Agathe", "Azencott",
role = "aut",
comment = c(ORCID = "0000-0003-1003-301X")))
Description: martini deals with the low power inherent to GWAS studies by using
prior knowledge represented as a network. SNPs are the vertices of the
network, and the edges represent biological relationships between them
(genomic adjacency, belonging to the same gene, physical interaction between
protein products). The network is scanned using SConES, which looks for
groups of SNPs maximally associated with the phenotype, that form a close
subnetwork.
License: GPL-3
LazyData: TRUE
Imports:
igraph (>= 1.0.1),
Matrix,
memoise (>= 2.0.0),
methods (>= 3.3.2),
Rcpp (>= 0.12.8),
snpStats (>= 1.20.0),
stats,
utils,
Suggests:
biomaRt (>= 2.34.1),
circlize (>= 0.4.11),
STRINGdb (>= 2.2.0),
httr (>= 1.2.1),
IRanges (>= 2.8.2),
S4Vectors (>= 0.12.2),
knitr,
testthat,
readr,
rmarkdown
Depends: R (>= 4.0)
LinkingTo:
Rcpp,
RcppEigen (>= 0.3.3.5.0)
RoxygenNote: 7.2.3
Encoding: UTF-8
biocViews: Software, GenomeWideAssociation, SNP, GeneticVariability, Genetics,
FeatureExtraction, GraphAndNetwork, Network
VignetteBuilder: knitr
URL: https://github.com/hclimente/martini
BugReports: https://github.com/hclimente/martini/issues