\brief Fitting atomic structures into a cryo-electron microscopy density map.

MultiFit is a computational method for simultaneously fitting atomic structures of components into their assembly density map at resolutions as low as 25Å. The component positions and orientations are optimized with respect to a scoring function that includes the quality-of-fit of components in the map, the protrusion of components from the map envelope, as well as the shape complementarity between pairs of components. The scoring function is optimized by an exact inference optimizer DOMINO that efficiently finds the global minimum in a discrete sampling space.

For more information please see the MultiFit website.

See the IMP::cnmultifit module for a similar protocol for handling symmetric complexes.

Generally, this module is not used directly; instead, the multifit command line tool is used. For an example, see [Modeling of 3sfd](@ref multifit_3sfd).

A webserver that uses both this module and the IMP::cnmultifit module is also available.

Build an anchor graph from a PDB file.

Author(s): Keren Lasker

Maintainer: benmwebb

License: GPL This library is free software; you can redistribute it and/or modify it under the terms of the GNU General Public License as published by the Free Software Foundation; either version 2 of the License, or (at your option) any later version.

Publications:

• See [main IMP papers list](@ref publications).
• K. Lasker, M. Topf, A. Sali, H. J. Wolfson, "Inferential optimization for simultaneous fitting of multiple components into a cryoEM map of their assembly", J Mol Biol 388, 2009