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After a civil war in Hell, Lucifer has been defeated and the Key to Hell is in Lord Desecrater's grasp. However, the rebellious Dominator has his own thoughts and keeps the Key to Hell away from Lord Desecrater and is forced to fight off his forces including three other demons - Decimator, Extricator and Lady Violator. While on Earth, undertaker and exocrist Dr. Payne is in charge of London's dead. His three daughters who play in their own rockband called Crowcut, accidentally open a gateway to Hell by invoking black magi-ck into their music via the Lost Chord and unleash Dominator. Luckily for humanity, Dominator is willing to defend mankind, even if he is only interested in Dr. Payne's eldest daughter, Tara. When Desecrater learns of what has happened on Earth, he seeks out help using his new human agent - the corrupt politician Bishop, to carry out the rest of his deeds.

This live-action/stop motion and CGI animated rarity was influenced by equal parts British B-horror films, television action adventure and Japanese anime. Dr. Churchill, a respected but reclusive scientist, uncovers evidence that the pre-Christian demons of ancient mythologies are real, and that they will return soon to reclaim the Earth as their own. He tries to warn the governments of the world, but is met with ridicule. His professional standing and credibility destroyed, he disappears. Later, his prediction comes true, as the gigantic extraterrestrials Baal and his consort Dygon descend on the world's capitols and begin the enslavement of humanity. Conventional militaries are unable to defend against the onslaught. All that stands between "The Anti-God" and the end of the world is Dr. Churchill and his covert resistance force of scientists and high-tech soldiers, DOOMSHIELD, aided by their secret weapon, an ancient magical semi-sentient mechanoid known as the Archangel Thunderbird. The vehicle requires a human pilot, but only someone with an incredibly rare psychological makeup can operate it. Enter Miki Manson, an extremely disturbed woman suffering from multiple personality disorder. The powers and abilities of the Archangel Thunderbird vary depending on which of Miki's personalities is in control when she enters the cockpit. Churchill and his assistants are challenged not just by the forces of Baal and Dygon, but also by the need to keep Miki under control so that she can continue to pilot the mechanoid.