- (1999) Novel: "Timeline" (filmed as Timeline (2003)).
- (1996) Novel: "Airframe".
- (1992) Novel: "Rising Sun" (filmed as Rising Sun (1993)).
- (1987) Novel: Sphere (filmed as Sphere (1998)).
- (1983) Book: "Electronic Life".
- (1982) (computer game Amazon) "Tellarium".
- (1977) Book: "Jasper Johns".
- (1976) Novel: "Eaters of the Dead" (filmed as The 13th Warrior (1999)).
- (1975) Novel: "The Great Train Robbery" (filmed as The Great Train Robbery (1978)).
- (1972) Novel (written as John Lange): "Binary" (filmed as Pursuit (1972)).
- (1970) Novel (written as John Lange): "Grave Descend".
- (1970) Novel (written as John Lange): "Drug of Choice".
- (1970) Book: "Five Patients: The Hospital Explained".
- (1974) Novel (written as John Lange): "Easy Go, 1968" (aka "The Last Tomb").
- (1969) Novel (written as John Lange): "Zero Cool".
- (1969) Novel (written as John Lange): "The Venom Business".
- (1968) Novel (written as Jeffery Hudson): "A Case of Need" (filmed as The Carey Treatment (1972)).
- (1967) Novel (written as John Lange): "Scratch One".
- (1966) Novel (written as John Lange): "Odds On".
- (1969) Novel: "The Andromeda Strain" (filmed as The Andromeda Strain (1971), The Andromeda Strain (2008)).
- Novel: "Volcano"
- (1995) Novel: "The Lost World" (sequel to "Jurassic Park").
- (2003) Novel: "Prey".
- (2006) Novel: "Next".
- (2004) Novel: "State of Fear".
- (1995) Novel: "Congo" (filmed as Congo (1995)).
- (1970) Novel (as "Michael Douglas", w/Douglas Crichton): "Dealing: Or the Berkeley-to-Boston Forty-Brick Lost-Bag Blues" (filmed as Dealing: Or The Berkeley-to-Boston Forty-Brick Lost-Bag Blues (1972)).
- (1972) Novel: The Terminal Man (filmed as The Terminal Man (1974)).
- (2009) Novel: "Pirate Latitudes" (published posthumously).
- (2011) Novel (completed by Richard Preston): "Micro" (published posthumously).
- (1961) Short Story: "Life Goes to Party".
- (1961) Short Story: "The Most Important Part of a Lab".
- (1993) Audible Audiobook of "The Andromeda Strain," written by Michael Crichton, narrated by Chris Noth; published by Random House AudioBooks, ISBN 0679437894.
- (2005) Audible Audiobook of "Kiss the Girls" (1995), written by Michael Crichton, narrated by Chris Noth and Robert Guillaume; published by Hachette Book Group USA, ISBN 1570420297.
- (2019) Poem: "¡Qué bonita es mi tierra!" - Sociedad Honoraria Hispánica magazine.
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