- Has one son, Edoardo (b.1990), with her ex husband.
- She graduated in computer programming and was first employed in a scientific analysis laboratory. She started her acting career in 1980, playing a supporting role in the comedy film La Compagna di viaggio by Ferdinando Baldi.
- In 2006, Grandi was a candidate in the list of Social Action, a right-leaning party led by Alessandra Mussolini, but she was not elected. The same year she published her first novel, L'amante del federale. In 2008, after a break of ten years, she returned to acting.
- In 1991 Serena married the antiquarian Beppe Ercole, 20 years her senior, with whom she had a son Edoardo; the couple divorced in 1998.
- After several minor roles, Serena took the title role in Tinto Brass' Miranda, which gave her the status of sex symbol in her native Italy and set the path for her stardom.
- In the 1990s, Grandi started to back away from the spotlight; during this time she focused her career on television series.
- In the early years of her film career she used the pseudonyms Daria Norman and Vanessa Steiger (in Antropophagus). The surname Grandi, later adopted as part of her definitive stage name, was that of her mother when she was maiden.
- She reached maximum popularity in the eighties thanks to her participation in some of the most famous films of Italian erotic cinema, in which she had the opportunity to show her busty pin-up forms.
- One of the first times she is remembered by the name of Serena Grandi was in a participation in the Rai 2 sexy late evening variety show Il cappello sulle ventitré, in which she performed some strip teases.
- Through the 1980s, Grandi made nearly 20 films, mainly appearing in commedie sexy all'italiana and erotic films, but also starring in some horror films. In 1987 Lamberto Bava gave her the role of Gloria in his film Delirium.
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