- Runs a cupcake and cheeseball business out of her Greenwich Village apartment when she is not acting.
- Occasionally works as a waitress at Mary's Fish Camp in the West Village.
- Wrote the play, "The Book of Liz", with her older brother, David Sedaris.
- She uses the money she gets for appearing on Late Show with David Letterman (1993) to buy a new pair of shoes for her next appearance.
- Raised Greek Orthodox.
- Amy keeps a free-roaming mini-rex rabbit named Dusty, which she adopted from a rabbit rescue. Dusty's "bunny condo" was designed by her friend, designer Todd Oldham. Amy named her baked-goods business after her first rabbit, Tattletail, a Netherlandish dwarf. ("Tattletail Industries" has since become "Amy's Cupcakes.") She is active in a NYC rabbit rescue and shelter, and is an honorary educator of the House Rabbit Society.
- An alumna of the Second City and Annoyance Theatre in Chicago, Illinois.
- Is of half Greek descent.
- Failed first grade.
- Release of the book "The Book of Liz," by Amy and her brother, David Sedaris. (2002)
- Release of her book, "Wigfield: The Can-Do Town That Just May Not" by Amy with Paul Dinello and Stephen Colbert. (2003)
- Release of her book, "I Like You: Hospitality Under the Influence". (2006)
- Idolized her brother David Sedaris when she was a child.
- She is best known for her grotesque yet strangely endearing character "Jerri" from Strangers with Candy (1999).
- Enjoys playing characters who "like themselves".
- Of all her relatives, she was closest to her father.
- She was nominated for a 1993 Joseph Jefferson Award for Actress in a Revue for "Truth, Justice or the American Way" at the Second City Theatre in Chicago, Illinois.
- Collects decorative cupcake picks.
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