Set about a year after Borderlands 3, weapon manufacturer Tediore has begun invading the planet Promethea. Anuradha Dhar, Octavio Wallace-Dhar and Francine Miscowicz, each with their own hopes and dreams, as they fight against Tediore agents, as well as monsters and criminals that roam the planet. The trio must also work together as they seek a vault key which may grant them access to a vault stashed with treasures that may change their lives forever.