Renal Function Test something wrong with GF Test
• Standard Method for GFR
1. Glomerular Filtration Test
• Demonstrate progression of renal
- Clearance test, most studied disease or response to therapy
- Testing substances, cleared away
subs ✓ Progression kung talagang
- “CCT” Creatinine Clearance Test – nagkakaroon ng poor on GFR. It
muscle metabolism means eto yung mga clinical
2. Tubular Reabsorption Test significance.
- Ability to concentrate the blood
- Adjust, check the amount • Not give reliable estimates of GFR
- Concentration test (Approximately 40% of filtered urea is
3. Tubular Secretion and Renal Blood reabsorbed)
Flow Test • It is about 50% of creatinine
clearance.
Glomerular Filtration Rate
First function that we have to measure is all
about GLOMERULAR FILTRATION RATE.
Clearance Test
• The standard tests used to measure
the filtering capacity of the glomeruli
• Measures the rate at which the
kidneys are able to remove (to clear)
a filterable substance from the blood
✓ Kasi eto yung primary function of
kidney
• The substance analyzed must be one
that is neither reabsorbed nor
secreted by the tubules
✓ Example is creatine, BUN and so on
• Stability of substance in urine during
24- hour urine collection
• Consistency of plasma level
✓ Kaya titingnan natin ang mga
advantages, disadvantages or some
of interfering substances
• Substances availability to the body
• Availability of tests for analysis of the
substance
• Reported in mL/min
GLOMERULAR FILTRATION RATE:
CLEARANCE TEST
UREA CLEARANCE TEST CREATININE CLEARANCE
• Urea – 1st subs
The earliest or oldest GF Test that time is UREA • Inulin
CLEARANCE TEST
• Normal part of the body
✓ Kung sobrang mataas sya there’s
• Stable amount
• Everyday stable
• Ideal subs for clearance test
• Only filtered, clear away ng
glomerulus
• Reabsorbed or secretion is not
significant
• Affected by the diet, height/weight,
surface area
• Most commonly used; screening
method of GFR
• Excellent measurement of renal
function
✓ Creatinine is freely filtered by the
glomerulus but not reabsorbed.
• A measure of the completeness of a
24-hour urine collection
✓ Part of preparation for the test of this
creatine clearance is collection of 24-
hour urine
✓ measure of the completeness of a 24-
hour urine collection is considered as
reliable to achieve the accuracy of the
result
✓ ibig sabihin nagkakaroon ng problem
when we are not following the
guidelines on 24 hour urine collection
pwedeng kulang kasi sobrang
importante ng exact volume in 24hour
collection
