Grams: “TECHNOLOGY” Phone: Off: 0884-2300993
Email: [Link]@[Link]. Fax: 0884-2300909, 912.
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY: KAKINADA
KAKINADA-533003, Andhra Pradesh (India)
From:
[Link],
Asst. Professor in CSE &
Addl. Controller of Examinations
J.N.T. University, KAKINADA-533003.
To:
Dr. G A Manivasagam,
Asst. Prof in Pharmacy Department,
Annamalai University, Tamilnadu.
I am advised to inform you that you are appointed as subject expert to set the question papers as
per the details noted below, you are requested to set the question papers as word documents and
send as soft copy to [Link]@[Link]. The hard copies of the question paper shall be sent
along with the remuneration bill in the covers enclosed. You are requested to keep this appointment
strictly confidential.
1. The paper consists of Part-I (Compulsory), Part-II & III. Part-I: Answer all Questions has
to be set which will have Twenty Multiple choice questions with at least four questions
from each unit and covering all the 5 units. Each Multiple choice question carries 1 mark.
Not more than four multiple choice questions are to be set from each unit. (20 x 1=20
Marks). Part-II: 3 questions (one from each unit) are to be set. The Student has to answer
any 2 questions. Each question carries 10 marks. (6 x 5 = 30). Part-III: 9 questions (Two
from each unit) are to be set. The Student has to answer any 7 questions. Each question
carries 5 marks. (7 x 5 = 35).
2. You are requested to prepare a balanced question paper within the prescribed syllabus covering
the entire syllabus. The duration of the examination is 3 hours and you are requested to prepare
the questions in such a way that student must be able to write each question in about 35-45
minutes.
3. You are requested to give the distribution of the marks for each question.
4. The figures and sketches can be drawn on a separate sheet and sent along with bill if the same
cannot be incorporated in word document.
5. The requirement of data books, codes, graphs etc. may please be indicated on the question
paper.
6. Remuneration for setting one question paper: B. Pharmacy. Rs 1000/- per set
You are requested to reject the offer and intimate the same to the Addl. Controller of
Examinations, if any of your relatives are writing the examination or if you are involved in
any extra assignment in any tutorial/coaching centers.
Course B. Pharmacy (R17)
Name of the Examination II B. Pharmacy II Sem (PCI) Supple Exams, Feb-2025
Subject Physical Pharmaceutics-II (BP403T)
No. Of Question Papers 2 (two sets)
Last date of submission 07.02.2025
Enclosures:
1. Syllabus
2. Model Paper
3. Bill of Payment
Additional Controller of Examinations
BP 403 T. PHYSICAL PHARMACEUTICS-II (Theory)
45Hours
Scope: The course deals with the various physica and physicochemical properties, and principles
involved in dosage forms/formulations. Theory and practical components of the subject help the
student to get a better insight into various areas of formulation research and development, and
stability studies of pharmaceutical dosage forms.
Objectives: Upon the completion of the course student shall be able to
1. Understand various physicochemical properties of drug molecules in the designing the dosage
forms
2. Know the principles of chemical kinetics & to use them for stability testing nad determination of
expiry date of formulations
3. Demonstrate use of physicochemical properties in the formulation development and evaluation of
dosage forms.
Course Content:
UNIT-I 07 Hours
Colloidal dispersions: Classification of dispersed systems & their general characteristics, size &
shapes of colloidal particles, classification of colloids & comparative account of their general
properties. Optical, kinetic & electrical properties. Effect of electrolytes, coacervation, peptization&
protective action.
UNIT-II 10 Hours
Rheology: Newtonian systems, law of flow, kinematic viscosity, effect of temperature, non-
Newtonian systems, pseudoplastic, dilatant, plastic, thixotropy, thixotropy in formulation,
determination of viscosity, capillary, falling Sphere, rotational viscometers
Deformation of solids: Plastic and elastic deformation, Heckel equation, Stress, Strain, Elastic
Modulus
UNIT-III 10 Hours
Coarse dispersion: Suspension, interfacial properties of suspended particles, settling in suspensions,
formulation of flocculated and deflocculated suspensions. Emulsions and theories of emulsification,
microemulsion and multiple emulsions; Stability of emulsions, preservation of emulsions, rheological
properties of emulsions and emulsion formulation by HLB method.
UNIT-IV 10Hours
Micromeretics: Particle size and distribution, mean particle size, number and weight distribution,
particle number, methods for determining particle size by different methods, counting and separation
method, particle shape, specific surface, methods for determining surface area, permeability,
adsorption, derived properties of powders, porosity, packing arrangement, densities, bulkiness & flow
properties.
UNIT-V 10 Hours
Drug stability: Reaction kinetics: zero, pseudo-zero, first & second order, units of basic rate
constants, determination of reaction order. Physical and chemical factors influencing the chemical
degradation of pharmaceutical product: temperature, solvent, ionic strength, dielectric constant,
specific & general acid base catalysis, Simple numerical problems. Stabilization of medicinal agents
against common reactions like hydrolysis & oxidation. Accelerated stability testing in expiration
dating of pharmaceutical dosage forms. Photolytic degradation and its prevention.
