Formulation Guide
Sytenol® A
Sytenol® A (INCI: Bakuchiol)
Sytenol® A is the first natural alternative to Retinol without having any of the
negatives associated with Retinol.
• Photochemically & hydrolytically stable.
• Can be used during the day.
• Multiple comparative studies revealed Sytenol® A to be a true alternative
to retinol.
• Modulates retinoid-binding & metabolizing genes.
• Significantly improves multiple dermal & dermo-epidermal junction
genes/proteins.
• Collagen I, III & IV stimulator.
• Provides hydration by up-regulating synthesis of hyaluronic acid & aquaporin 3.
• Clinically proven to reduce multiple signs of aging.
– Significant reduction in roughness & dryness and fine lines & wrinkles
– Improvement in skin tone, elasticity & firmness, and radiance & rightness
• Sytenol® A is a natural and well-defined material with a purity level of ≥ 99%.
Formulation Guidelines
Formulated products containing Sytenol® A will remain stable over time. Long
term stability testing on emulsions, anhydrous systems and water-based se-
rums containing 0.5-1.0% Sytenol® A showed practically no color shift at 45C
and RT. All formulas have completed two months stability at room tempera-
ture & 45C and three cycles of Freeze/Thaw.
• Sytenol® A should be used at a level of 0.5 – 1% (w/w) of finished formulation.
• Sytenol® A is miscible in a wide variety of the following:
– Emollients such as capric/caprylic triglycerides, C12-15 alkyl benzoates,
dicaprylyl ether
– Vegetable oils such as sunflower oil, jojoba oils, olive oil
• Sytenol® A is immiscible in dimethicone.
• Sytenol® A can be added directly to the oil phase.
• Sytenol® A is heat stable at 80ºC for 12 hours.
• Sytenol® A is a phenolic compound. Therefore, presence of iron or copper
ions must be avoided to eliminate coloration due to the interaction with
these metal ions. Addition of a small amount of disodium EDTA (0.1%) or
other chelating agents resolves this problem.
• The finished product must be acidic, preferably having pH below 6.5. A pH
of 4.0-6.0 is recommended.
• Sytenol® A is incompatible with sodium hydroxide, potassium hydroxide
and aluminum hydroxide.
• Sytenol® A can be formulated into color cosmetic products as long as the
pigments are coated.
• For water-based serums, surfactants such as PEG-40 Hydrogenated Castor
Oil and Polysorbate 20 are recommended.
• Avoid prolong exposure to sunlight. Opaque and airless packaging is highly
recommended for maintaining product integrity and stability over time.
Transparent Serum with Sytenol® A
Formulation # RC-04-38.01
INCI name Trade Name/Supplier % w/w
Phase A
Water (demineralized) 82.15
Glycerin Glycerin/Jeen 2.00
Propanediol Zemea/DuPont 2.50
Benzyl Alcohol & Dehydroacetic Acid Geogard 221/Lonza 1.00
Trisodium Ethylenediamine Disuccinate Natrlquest E30/Innospec 0.10
Phase B
Sodium Hyaluronate Crystalhyal HA/Givuduan 1.25
Phase C
PEG-40 Hydrogenated Castor Oil Eumulgin CO 40/BASF 4.00
Polysorbate 20 Ritabate 20/Rita 6.00
Bakuchiol Sytenol® A/Sytheon 0.50
Total 100.00
Procedure:
Weigh Phase A in the main kettle equipped with a homogenizer. Sprinkle in Phase B. Mix until uni-
form. Weigh Phase C in a side kettle. Heat to 40ºC. Mix until all solids dissolved. When both phases are
uniform, add Phase C to Phase AB. Mix for 5-10 minutes.
Notes:
pH: 5.5-6.0; Viscosity: Spindle-TD, S94; Speed-2.0 rpm; Range: 3,000-6,000 mPas
Hydrating Anti-Aging Oil with Sytenol® A and HydraSynol® DOI
Formulation # RC-02-32.02
INCI name Trade Name/Supplier % w/w
Phase A
Prunus Amygdalus Dulcis Oil Sweet Almond Oil/Rita 36.00
Caprylic/Capric Triglyceride Myritol 318/BASF 27.00
Ethyl Macadamiate Floramac 10/FloraTech 8.80
Helianthis Annuus (Sunflower) Seed Oil FloraSun 90/FloraTech 3.00
Isosorbide Dicaprylate HydraSynol® DOI/Sytheon 2.00
Tocopheryl Acetate Vitamin E Acetate/BASF 0.20
Persea Gratissima (Avocado) Oil Avocado Oil/Rita 1.00
Dicaprylyl Ether Cetiol OE/BASF 20.00
Squalene Jeechem Squalene/Jeen 1.00
Citrus Paradisi (Grapefruit) Peel Oil Grapefruit Oil/Jeen 0.50
Bakuchiol Sytenol® A/Sytheon 0.50
Total 100.00
Procedure:
Weigh Phase A in the main kettle equipped with a stir bar. Mix until uniform.
Neck & Decolletage Cream with Sytenol® A & Synoxyl® AZ
Formulation # RC-04-25.01
INCI name Trade Name/Supplier % w/w
Phase A
Water (demineralized) 56.60
Water & Sodium Benzoate & Potassium Sorbate Euxyl K 712/Schulke 1.00
Glycerin Glycerin/Rita 3.00
Phase B
Xanthan Gum Vanzan NF/Vanderbilt 0.40
Phase C
Caprylic/Capric Triglyceride Jeechem CTG/ Jeen 17.00
Dicaprylyl Ether Cetiol OE/BASF 5.00
Sorbitan Stearate Protachem SMS/Protameen 2.00
Glyceryl Stearate Hallstar GMS SE/Hallstar 3.00
Isosorbide Dicarpylate Hydra Synol® DOI/Sytheon 4.00
Bakuchiol Sytenol® A/Sytheon 0.50
Ethyl Linoleate Synovea® EL/Sytheon 4.00
Phase D
Acetyl Zingerone Synoxyl® AZ/Sytheon 0.50
Propanediol Zemea/DuPont 3.00
Total 100.00
Procedure:
Weigh Phase A in the main kettle equipped with a homogenizer. Sprinkle in Phase B. Once dispersed,
heat to 65º-70ºC. Weigh Phase C in a side kettle. Heat to 70º-75ºC. When both phases are at the proper
temperature, add Phase C to Phase AB. Mix for 15-20 minutes. Weigh Phase D in a side kettle and heat
to 45ºC. Mix until all solids are dissolved. Switch to side sweep mixing and cool to 45ºC. Add Phase D
to Phase ABC. Mix for 5-10 minutes. Finish cooling the batch to room temperature.
Notes:
pH: 5.5-6.0; Viscosity: Spindle-TE, S95; Speed-0.3 rpm; Range: 100,000-400,000 mPas
Anhydrous Lip Gloss with Sytenol® A
Formulation # RC-03-177.01
INCI name Trade Name/Supplier % w/w
Phase A
Polybutene Indopol H-100/Ineos 34.60
Ricinus Communis (Castor) Seed Oil Lipovol CO/Lipotech 26.00
Helianthus Annuus (Sunflower) Seed Oil Sunflower Oil/Jeen 20.10
Squalane Squalane/Jeen 3.00
Cocos Nucifera (Coconut) Oil Coconut Oil/Protameen 3.00
Butyrospermum Parkii (Shea Butter) Shebu Refined/Rita 3.00
Glyceryl Behenate Compritol 888 Pellets/Gattefosse 1.00
Beeswax NF White Beeswax/Koster Keunen 4.00
Tocopheryl Acetate Vitamin E Acetate/Jeen 0.30
Silica Valvance Touch 210/DSM 2.00
Sesamum Indicum (Sesame) Seed Oil Sesame Seed Oil/Rita 2.00
Bakuchiol Sytenol A/Sytheon
®
0.50
Total 100.00
Procedure:
Weigh Phase A in the main kettle equipped with a propeller mixer. Heat to 75º-80ºC. Mix until uni-
form. Switch to side sweep mixing and cool to room temperature.
Notes:
Viscosity: Spindle-TE, S95; Speed-0.3 rpm; Range: 200,000-400,000 mPas
Minimalist Lotion with Sytenol® A
Formulation # RC-03-158.01
INCI name Trade Name/Supplier % w/w
Phase A
Water (demineralized) 80.80
Water & Sodium Benzoate & Potassium Sorbate Euxyl K 712/Schulke 1.00
Glycerin Glycerin/Rita 3.00
Panthenol Ritapan DL, 50%/Rita 0.50
Phase B
Xanthan Gum Vanzan NF/Vanderbilt 0.40
Phase C
Beeswax NF White Beeswax/Koster Keunen 2.00
Tocopheryl Acetate Vitamin E Acetate/Jeen 0.30
Persea Gratissima (Avocado) Oil Avocado Oil/Rita 7.00
Glyceryl Stearate Protachem GMS-D/Protameen 2.50
Stearic Acid Stearic Acid/Protameen 1.50
Bakuchiol Sytenol® A/Sytheon 1.00
Total 100.00
Procedure:
Weigh Phase A in the main kettle equipped with a homogenizer. Sprinkle in Phase B. Once dispersed,
heat to 65º-70ºC. Weigh Phase C in a side kettle. Heat to 70º-75ºC. When both phases are at the proper
temperature, add Phase C to Phase AB. Mix for 15-20 minutes. Switch to side sweep mixing and cool
to room temperature.
Notes:
pH: 5.5-6.0; Viscosity: Spindle-TE, S95; Speed-0.3 rpm; Range: 200,000-400,000 mPas
Anti-Aging Hydrating Gel Cream with 0.5%Sytenol® A and HydraSynol® DOI
Formulation # RC-01-56.02
INCI name Trade Name/Supplier % w/w
Phase A
Water 78.45
Disodium EDTA RonaCare Disodium EDTA/EMD 0.10
Glycerin Glycerin/Rita 2.00
Butylene Glycol Jeechem BUGL/Jeen 3.00
Steareth-2 Procol SA-2/Protameen 1.25
PEG-8 Pluracare E 400/BASF 2.00
Niacinamide Niacinamde/DSM 2.00
Caffeine Caffeine/EMD 0.50
Caprylyl Glycol & Phenoxyethanol & Hexylene Glycol Jeecide Cap-2/Jeen 1.00
Phase B
Ammonium Acryloyldimethyltaurate/VP Copolymer Aristoflex AVC/Clariant 1.10
Phase C
Cyclopentasiloxane Xiameter PMX-0245/Dow Corning 5.00
Dimethicone Dimethicone Fluid/Making Cosmetics 1.00
Tocopheryl Acetate Vitamin E Acetate/Jeen 0.10
Isosorbide Dicaprylate HydraSynol® DOI/Sytheon 2.00
Bakuchiol Sytenol® A/Sytheon 0.50
Total 100.00
Procedure:
Weigh Phase A in the main kettle equipped with a homogenizer. Sprinkle in Phase B. Once dispersed,
heat to 45º-50ºC. Weigh Phase C in a side kettle. Add Phase C to Phase AB. Mix for 15-20 minutes.
Notes:
pH – 5.0-5.5; Viscosity: Spindle-TF, S96; Speed-0.3 rpm, Range: 500,000-800,000 mPas
Acne Control Lotion with Sytenol® A and Salicylic Acid
Formulation # RC-01-11.02
INCI name Trade Name/Supplier % w/w
Phase A
Water 72.20
Disodium EDTA RonaCare Disodium EDTA/EMD 0.10
Glycerin Glycerin/Rita 3.00
Butylene Glycol Jeechem BUGL/Jeen 2.00
Caprylyl Glycol & Phenoxyethanol & Hexylene Glycol Jeecide Cap-2/Jeen 1.00
Polysorbate 20 Ritabate 20/Rita 1.00
Tromethamine Tris Amino/Angus 0.80
Phase B
Ethoxydiglycol Transcutol CG/Gattefosse 4.50
Salicylic Acid Salicylic Acid/Novacyl 2.00
Phase C
Xanthan Gum Vanzan NF/Vanderbilt 0.50
Phase D
Dicaprylyl Ether Cetiol OE/BASF 4.00
Cetyl Alcohol Cetyl Alcohol/Protameen 1.50
Tocopheryl Acetate Vitamin E Acetate/Jeen 0.20
Glyceryl Stearate & PEG-100 Stearate Protachem GMS-165/Protameen 3.00
Cetearyl Alcohol & Ceteareth-20 Ritapro 300/Rita 1.00
Beeswax Natural Beeswax/Rita 1.00
Bakuchiol Sytenol® A/Sytheon 1.00
Phase E
Polyacrylamide & C13-14 Isoparaffin & Laureth-4 Sepigel 305/Seppic 2.00
Total 100.00
Procedure:
Weigh Phase A in the main kettle equipped with a homogenizer. Weigh Phase B in a side kettle and
mix until all solids are dissolved. Sprinkle Phase C into Phase A. Once dispersed, add pre-mixed
Phase B and heat to 70º-75ºC. Weigh Phase D in a side kettle equipped with a propeller mixer. Heat to
70º-75ºC. Once both phases are at the proper temperature, add Phase D to Phase ABC. Mix for 15-20
minutes. Add Phase E and mix for 5 minutes. Switch to side sweep mixing and cool the batch to room
temperature.
Notes:
pH – 4.0-4.5; Viscosity: Spindle-TE, S95 Speed-0.3 rpm, Range: 500,000-900,000 mPas
Color-Change Lip Gloss with Sytenol® A
Formulation # RC-03-177.02
INCI name Trade Name/Supplier % w/w
Phase A
Polybutene Indopol H-100/Ineos 34.55
Ricinus Communis (Castor) Seed Oil Lipovol CO/Lipotech 26.00
Helianthus Annuus (Sunflower) Seed Oil Sunflower Oil/Jeen 20.10
Squalane Squalane/Jeen 3.00
Cocos Nucifera (Coconut) Oil Coconut Oil/Protameen 3.00
Butyrospermum Parkii (Shea Butter) Shebu Refined/Rita 3.00
Glyceryl Behenate Compritol 888 Pellets/Gattefosse 1.00
Beeswax NF White Beeswax/Koster Keunen 4.00
Tocopheryl Acetate Vitamin E Acetate/Jeen 0.30
Silica Valvance Touch 210/DSM 2.00
CI 45410 (Red 27) Unicert Red K7053-J/Sensient 0.05
Persea Gratissima (Avocado) Oil Avocado Oil/Rita 2.00
Bakuchiol Sytenol® A/Sytheon 0.50
Total 100.00
Procedure:
Weigh Phase A in the main kettle equipped with a propeller mixer. Heat to 75º-80ºC. Mix until uni-
form. Pour samples at 75ºC.
Notes:
Viscosity: Spindle-TF, S96; Speed-0.3 rpm; Range: 1,000,000-2,000,000 mPas
Brow Serum with Sytenol® A
Formulation # RC-04-02.01
INCI name Trade Name/Supplier % w/w
Phase A
Water (demineralized) 70.55
Denatured Alcohol SDA 40/Quality Chemical 15.00
Glycerin Glycerin/Jeen 3.00
Phenoxyethanol & Ethylhexylglycerin Euxyl PE 9010/Schulke 1.00
D-Panthenol & Water Ritapan DL, 50%/Rita 2.00
Sodium PCA Sodium PCA/Rita 1.00
Aloe Barbadensis Leaf Juice Biovera 200X Aloe/Hallstar 2.00
Trisodium Ethylenediamine Disuccinate Natrlquest E30/Innospec 0.10
Phase B
Xanthan Gum Vanzan NF/Vanderbilt 0.35
Sodium Hyaluronate Crystalhyal HA/Givuduan 0.50
Phase C
PEG-40 Hydrogenated Castor Oil Eumulgin CO 40/BASF 3.50
Bakuchiol Sytenol® A/Sytheon 0.50
Total 100.00
Procedure:
Weigh Phase A in the main kettle equipped with a homogenizer. Sprinkle in Phase B. Mix until uni-
form. Weigh Phase C in a side kettle. Heat to 40ºC. Mix until all solids dissolved. When both phases
are uniform, add Phase C to Phase AB. Mix for 5-10 minutes.
Procedure:
pH: 5.0-5.5; Viscosity: Spindle-TE, S95; Speed-0.3 rpm; Range: 20,000-40,000 mPas
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[Link] • info@[Link]
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[Link] • sytheon@[Link]
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[Link] • apac@[Link]
Tel.:+65 91 31 21 65
Disclaimer
The information given and the recommendations made herein are based on our research and literature search and are believed to be accurate but no guarantee of their accuracy is made. This
information is intended to be helpful, but no warranty is expressed or implied as to the results obtained from use in the formulation, procedure or products suggested herein. Neither is any
permission or recommendation to practice any invention covered by patent either expressed or implied.
