Hormonal Control of the
Reproductive System
Gonadotropin-Releasing Hormone
(GnRH)
Follicle Stimulating Hormore (FSH)
Luteinizing Hormone (LH)
The Reproductive Cycles of Females
• In females, the secretion of hormones and the
reproductive events they regulate are cyclic
• 2 human female cycles are:
– The menstrual cycle
– The ovarian cycle
The Human Female Reproductive Cycle: A Closer Look
• The female reproductive cycle is one integrated
cycle involving two organs: the uterus and ovaries
• Secretion of GnRH from the hypothalamus and of
FSH and LH from the anterior pituitary
orchestrates the female reproductive cycle
• Five kinds of hormones participate in an elaborate
scheme involving positive and negative feedback
Animation: Ovulation
Animation: Post Ovulation
Control by hypothalamus
Inhibited by combination of
estrogen and progesterone
Hypothalamus
Stimulated by high levels
GnRH of estrogen
Anterior pituitary Inhibited by low levels of
estrogen
FSH LH
Pituitary gonadotropins
in blood
LH
FSH
FSH and LH stimulate LH surge triggers
follicle to grow ovulation
Ovarian cycle
Growing follicle Corpus Degenerating
Mature corpus luteum
luteum
follicle
Follicular phase Ovulation Luteal phase
Estrogen secreted Progesterone and
by growing follicle in estrogen secreted
increasing amounts by corpus luteum
Ovarian hormones Peak causes
in blood LH surge
Estrogen Progesterone
Estrogen level Progesterone and estro-
very low gen promote thickening
of endometrium
Uterine (menstrual) cycle
Endometrium
Menstrual flow phase Proliferative phase Secretory phase
Days
0 5 10 14 15 20 25 28
The Ovarian Cycle
• In the ovarian cycle, hormones stimulate follicle
growth, which results in ovulation
The Ovarian Cycle
• Following ovulation, the follicular tissue left behind
transforms into the corpus luteum
Menstrual Cycle
• Ovulation occurs after the endometrium has
started to thicken in preparation for implantation
• The endometrium is shed from the uterus in a
bleeding called menstruation
• Sexual receptivity is not limited to a timeframe
The Uterine (Menstrual) Cycle
• Cycle after cycle, the maturation and release of
egg cells from the ovary are integrated with
changes in the uterus
• If an embryo has not implanted in the
endometrium by the end of the secretory phase, a
new menstrual flow commences
Menopause
• After about 450 cycles, human females undergo
menopause, the cessation of ovulation and
menstruation
Hormonal Control of the Male Reproductive
System
• Testosterone and other androgens are directly
responsible for the primary and secondary sex
characteristics of the male
• Androgen secretion and sperm production are
controlled by hypothalamic and pituitary hormones
Animation: Male Hormones
LE 46-14
Stimuli from other
areas in the brain
Hypothalamus
GnRH
Anterior
pituitary
Negative
feedback
FSH LH
Leydig cells
make
testosterone
Sertoli cells Primary and
secondary sex
characteristics
Spermatogenesis Testis