Diarrhea:
Epidemiology & Etiology
Prod Dr Md Nazrul Islam
Head of the Department of Pediatrics
Mymensingh Medical College
The problem of diarrhea in
young children
3-4 episodes / child / year
3,200,000 deaths / year
Causes about 12% of infant
deaths in developing countries
Contributes to malnutrition
Diarrhoea: Definition
It is defined as the passage of three
or more loose or watery stools in a
24- hr period, a loose stool being
one that would take the shape of a
container.
Mothers may define diarrhea in
exclusively breast-fed young infants
as an increase in stool frequency or
liquidity that they consider abnormal.
Three clinical types of
diarrhea
Type Greatest danger
Acute watery Dehydration
Potassium loss
Dysentery Tissue damage
Toxemia
Persistent Malnutrition
Acute Watery Diarrhoea
Begins acutely lasts less than
14 days, and involves the
passage of frequent loose or
watery stools without visible
blood.
Causes dehydration
Contribute to malnutrition
when food intake is reduced
Dysentery
Diarrhoea with visible blood in
the faeces
It causes anorexia, rapid wt loss
and damage to the intestinal
mucosa by the invasive bacteria
Dehydration may occur if stools
are watery
Persistent diarrhea
Begins acutely as watery
diarrhea or as dysentery but is
of unusually long duration (at
least 14 days)
Marked weight loss is frequent;
diarrheal stool volume may also
be great, with a risk of
dehydration
Epidemiology of
Diarrhea
Transmission: Fecal-Oral
By ingestion of fecally
contaminated water or food
Direct person-to-person
transmission, and
Direct contact with infected
feces
Risk factors for
developing diarrhea
Behavioral risk factors for
diarrhea
Failure to breastfeed exclusively
for first 6 months of life
Using feeding bottles
Eating food hours after cooking
it
Drinking contaminated water
Not washing soiled hands
Not disposing of feces safely
Host factors that affect incidence
or severity of diarrhea
Failure to continue
breastfeeding until the child is at
least 2 years of age
Malnutrition
Current or recent measles
Immunodeficiency or
Immunosuppression
Risk factors for persistent
diarrhea
Age below 1 year
Malnutrition
Recent introduction of animal
milk
Recent acute diarrhea
Previous persistent diarrhea
Seasonality of diarrhea
In tropical areas –
Viral diarrheas → in cool dry
season
Bacterial diarrheas → in hot wet
season
In temperate areas –
Viral diarrheas → in winter
Bacterial diarrheas → in summer
Epidemics and Pandemics
Most agents that cause diarrhea are
endemic in most developing
countries. These are responsible for
regular seasonal outbreaks.
An epidemic or pandemic may occur
when a microbial mutant develops
against which persons are not
immune or when living conditions
change in ways that facilitate the
spread of infection.
Etiology of diarrhea
Causes of acute watery
diarrhea in children
Rotavirus
Enterotoxigenic E. coli
Shigella
Campylobacter jejuni
Vibrio cholerae
Cryptosporidium