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Hyperuricemia Cancer Presentation

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16 views4 pages

Hyperuricemia Cancer Presentation

Uploaded by

boyxb
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd

Hyperuricemia as a Contributing

Factor

NAME :- VERMA ANURAG


ROLL NO. 238
DEPARTMENT OF BIOCHEMISTRY
What is Hyperuricemia?
• Definition: Serum uric acid > 7 mg/dL in men, > 6
mg/dL in women
• Causes:
- Increased production (purine metabolism, tumor
lysis)
- Decreased excretion (renal impairment, drugs)
• Clinical associations: Gout, metabolic syndrome,
cardiovascular disease
• Emerging link: Cancer risk and progression
Pathophysiological Connections

• Chronic inflammation - Uric acid crystals activate


NLRP3 inflammasome
• Oxidative stress - Xanthine oxidase generates
reactive oxygen species (ROS)
• Cellular proliferation & DNA damage - ROS →
mutations, genomic instability
• Tumor microenvironment - Elevated uric acid alters
immune responses, promotes angiogenesis
Hyperuricemia and Cancer: Clinical
Perspective
• Hyperuricemia: a potential biomarker for cancer
risk
• Target for preventive interventions - Xanthine
oxidase inhibitors (allopurinol, febuxostat)
• Research gaps:
- Causation vs correlation
- Cancer-specific risks (colorectal, breast, liver,
hematologic)

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