Kelly L. Olson, Ph.D.
Salt Lake City, Utah, United States
3K followers
500+ connections
About
Dr. Kelly Olson, is a neuroscientist, author, and keynote speaker who believes that…
Activity
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Section 2 of our Millennium Health Signals Report Volume 5 reveals that fentanyl often represents a mixture of fentanyl and various fentanyl…
Section 2 of our Millennium Health Signals Report Volume 5 reveals that fentanyl often represents a mixture of fentanyl and various fentanyl…
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4 months away from 12 years with Millennium Health. 3rd year being recognized in Winners Circle. Feeling honored for having the opportunity to…
4 months away from 12 years with Millennium Health. 3rd year being recognized in Winners Circle. Feeling honored for having the opportunity to…
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Still relishing in the glory of this years Winners Circle announcement last week at our National Sales Meeting. It was my fourth time being on stage,…
Still relishing in the glory of this years Winners Circle announcement last week at our National Sales Meeting. It was my fourth time being on stage,…
Liked by Kelly L. Olson, Ph.D.
Experience
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Dr Kelly Olson
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Education
Licenses & Certifications
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RPSGT
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Volunteer Experience
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Aboriginal diabetes committee member
FF/RR Diabetes/Dialysis Committee
- 1 year
Health
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Executive Committee Member
World Health Organization Safe Communities/RR District Safety Commission
- 2 years
Education
Executive committee member responsible for planning and hosting the World Health Organization Safe Communities conference in Northwestern Ontario. Was also a guest speaker at this conference.
Publications
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NF-kappaB activated by ER calcium release inhibits Abeta-mediated expression of CHOP protein: enhancement by AD-linked mutant presenilin 1
Experimental neurology, 2007, Vol.208(2), pp.169-76 [Peer Reviewed Journal]
Mutations in presenilin which result in early-onset Alzheimer disease (AD) cause both increased calcium release from intracellular stores, primarily endoplasmic reticulum (ER), and changes in NF-kappaB activation. Some studies have also reported that neurons containing AD-linked mutant presenilins (mPS1) show increased vulnerability to various stresses, while others report no differences in neuronal death. The majority of these reports center on potential changes in ER stress, because of the…
Mutations in presenilin which result in early-onset Alzheimer disease (AD) cause both increased calcium release from intracellular stores, primarily endoplasmic reticulum (ER), and changes in NF-kappaB activation. Some studies have also reported that neurons containing AD-linked mutant presenilins (mPS1) show increased vulnerability to various stresses, while others report no differences in neuronal death. The majority of these reports center on potential changes in ER stress, because of the enhanced ER calcium release seen in mPS1 neurons. One of the primary death effectors of ER stress is CHOP, also termed GADD153, which acts to transcriptionally inhibit protective cellular molecules such as Bcl-2 and glutathione. Because both CHOP and NF-kappaB are activated by increased intracellular calcium and stress, yet have diametrically opposite effects on neuronal vulnerability, we sought to examine this interaction in greater detail. We observed that IP3-mediated calcium release from ER, stimulated by Abeta exposure, mediated both CHOP expression and NF-kappaB DNA binding activity. Further, specific inhibition of NF-kappaB resulted in greater expression of CHOP, while activation of NF-kappaB inhibited CHOP expression. The enhanced release of calcium from IP3-mediated ER stores in mPS1 neurons stimulated increased NF-kappaB compared to normal neurons, which inhibited CHOP expression. Upon blockage of NF-kappaB, exposure to Abeta caused significantly greater Abeta-mediated CHOP expression and death in mPS1 neurons compared to normal neurons. Thus, AD-linked PS1 mutations disrupt the balance between stress-induced NF-kappaB and CHOP, resulting in greater dependence on stress-induced NF-kappaB activation in mPS1 neurons.
Other authors
More activity by Kelly L.
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Zak and Morgan enjoyed supporting our Director of Clinical Affairs Kelly L. Olson, Ph.D. when she presented at the MARRCH conference last week.
Zak and Morgan enjoyed supporting our Director of Clinical Affairs Kelly L. Olson, Ph.D. when she presented at the MARRCH conference last week.
Liked by Kelly L. Olson, Ph.D.
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Alaska Public Media Reporter Rachel Cassandra recently sat with Eric and Kelly from our clinical team to discuss Alaska's 4th Wave of the Opioid…
Alaska Public Media Reporter Rachel Cassandra recently sat with Eric and Kelly from our clinical team to discuss Alaska's 4th Wave of the Opioid…
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As someone who spends much of my time delving into the molecular intricacies of complex biological processes, stepping outside and gazing at the…
As someone who spends much of my time delving into the molecular intricacies of complex biological processes, stepping outside and gazing at the…
Liked by Kelly L. Olson, Ph.D.
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After over 25 years in the U.S., today I officially became a U.S. citizen. While I missed voting in this election by a few days, I’m eager to engage…
After over 25 years in the U.S., today I officially became a U.S. citizen. While I missed voting in this election by a few days, I’m eager to engage…
Liked by Kelly L. Olson, Ph.D.
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A new Pain Managment Organization for PAs. Let's support them. https://lnkd.in/duYidR2U https://lnkd.in/dRu4ufBA
A new Pain Managment Organization for PAs. Let's support them. https://lnkd.in/duYidR2U https://lnkd.in/dRu4ufBA
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Thank you so much, Kenitra Kengga and Michelle Burks for driving to Genesis Medical Detox from Greenhouse Treatment Center! It was an honor to show…
Thank you so much, Kenitra Kengga and Michelle Burks for driving to Genesis Medical Detox from Greenhouse Treatment Center! It was an honor to show…
Liked by Kelly L. Olson, Ph.D.
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You show us all how to jump rope! Happy Holidays!
You show us all how to jump rope! Happy Holidays!
Liked by Kelly L. Olson, Ph.D.
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🧬Feeding the Gut to Fuel the Brain 🧠 An in-depth review in @NatMetabolism uncovers how the diet-microbiota-gut-brain axis influences brain health…
🧬Feeding the Gut to Fuel the Brain 🧠 An in-depth review in @NatMetabolism uncovers how the diet-microbiota-gut-brain axis influences brain health…
Liked by Kelly L. Olson, Ph.D.
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🧠 The Brains Defense ⚔️ The human brain is more than just a powerhouse of thought—it's a well-guarded fortress. From its bony armor to intricate…
🧠 The Brains Defense ⚔️ The human brain is more than just a powerhouse of thought—it's a well-guarded fortress. From its bony armor to intricate…
Liked by Kelly L. Olson, Ph.D.
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Happy Thanksgiving from all of us to you and yours!
Happy Thanksgiving from all of us to you and yours!
Liked by Kelly L. Olson, Ph.D.
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We started off the Thanksgiving a bit early at our annual Fall Fun Event complete with pies for all, specialty coffee/tea drinks, and trivia games.
We started off the Thanksgiving a bit early at our annual Fall Fun Event complete with pies for all, specialty coffee/tea drinks, and trivia games.
Liked by Kelly L. Olson, Ph.D.
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Dr. Ronald Klatz, MD, DO Worldhealth.net
Dr. Ronald Klatz, MD, DO Worldhealth.net
Liked by Kelly L. Olson, Ph.D.
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Dr. Ronald Klatz, MD, DO Worldhealth.net #gratitude #kindness #love #nature
Dr. Ronald Klatz, MD, DO Worldhealth.net #gratitude #kindness #love #nature
Liked by Kelly L. Olson, Ph.D.
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