New research published in the Journal of Clinical Psychiatry explores neural markers of suicide attempt using rs-fMRI. The study examines the relationship between inflammation markers, brain activity, and functional connectivity in patients with unipolar depression. Results show differences in brain activity and connectivity in regions associated with language and decision-making. This study sheds light on potential markers for suicidal behavior. #neuroscience #mentalhealthresearch #suicideprevention
HCPToday’s Post
More Relevant Posts
-
🌟 Exciting News! 🌟 I'm thrilled to share that our latest article, "Cognitive changes in patients with unipolar TRD treated with IV ketamine: A systematic review," has just been published in Progress in Neuro-Psychopharmacology & Biological Psychiatry. This systematic review highlights the potential neurocognitive benefits of intravenous (IV) ketamine treatment for patients with treatment-resistant depression (TRD). Key findings from our review include: • Positive Cognitive Outcomes: Most studies reported improvements in cognitive domains such as processing speed, working memory, verbal and visual memory, executive function, attention, emotional processing, and auditory verbal episodic memory following IV ketamine treatment. • Low Risk of Bias: The majority of studies exhibited a low risk of bias, enhancing the reliability of our findings. • Variability in Effects: While most studies showed positive outcomes, one study reported negative effects on verbal memory, highlighting the need for further research. • Limitations Noted: Our review noted limitations such as small sample sizes and a predominance of a female, Western, and Caucasian population, which constrain the generalizability of the findings. • Need for Further Research: There is a need for more research to elucidate long-term effects, control for confounders such as concomitant medications, and explore neurocognitive subgroups within the TRD population. A heartfelt thank you to Dr. Gustavo Vazquez MD, PhD, FRCPC for enriching my knowledge and experience in research. Your guidance has been invaluable. A special shoutout to the incredible Mood Disorder Team at Providence Care Hospital and Queen's University for their unwavering support and collaboration. This publication is a testament to our collective efforts and dedication. Our work was published in Progress in Neuro-Psychopharmacology & Biological Psychiatry, which has an impact factor of 5.6, reflecting the significance and quality of our research. 🔗 Read the full article here: https://lnkd.in/g_BBSyzW
To view or add a comment, sign in
-
-
Exploring New Frontiers in Psychiatry and Vision Science Continuing our series on cutting-edge interdisciplinary research, this latest feature dives into how the retina—a part of the central nervous system—can provide valuable insights into schizophrenia. By combining electroretinography (ERG) and optical coherence tomography (OCT), researchers are uncovering novel biomarkers for this complex condition. Article Spotlight: The Use of Electroretinography and Optical Coherence Tomography in Patients with Schizophrenia Authors: Duraković, D., Malojčić, B., Vuković, M., Radoš, M., & Vrabec, F. (2020) Link: https://lnkd.in/gVVZ8UfC Why This Matters Schizophrenia is a challenging disorder to diagnose and monitor, lacking reliable biological markers. The retina, sharing its origins with the brain, offers a non-invasive and accessible avenue to study neurodegeneration and neurotransmitter dysfunction, especially involving dopamine. Key Highlights 1️⃣ Electroretinography (ERG): Revealed reduced amplitudes in a-wave and b-wave, reflecting functional deficits in retinal processing. Altered implicit times correlate with negative and excitement symptoms, linking retinal and behavioral dysfunctions. 2️⃣ Optical Coherence Tomography (OCT): Identified thinning of the retinal nerve fiber layer (RNFL) and reduced macular volume, suggesting structural degeneration over time. Changes were associated with symptom severity and disease duration. 3️⃣ Dopaminergic Dysfunction: Both ERG and OCT findings support the dopamine hypothesis of schizophrenia, demonstrating how retinal changes mirror CNS dysfunction. My Takeaway This research reinforces the retina’s potential as a “window to the brain.” By integrating ERG and OCT into diagnostic workflows, clinicians may gain earlier insights into disease progression and treatment efficacy, paving the way for more personalized approaches in psychiatry. Your Thoughts? How do you see ophthalmic tools like ERG and OCT transforming mental health diagnostics? Let’s discuss the possibilities for interdisciplinary advancements! #Psychiatry #RetinalBiomarkers #Neurodegeneration #MentalHealthInnovation #SchizophreniaResearch
THE USE OF ELECTRORETINOGRAPHY AND OPTICAL COHERENCE TOMOGRAPHY IN PATIENTS WITH SCHIZOPHRENIA - PubMed
pubmed.ncbi.nlm.nih.gov
To view or add a comment, sign in
-
🚨 New Research Sheds Light on the Neurobiology of Anorexia Nervosa 🚨 A groundbreaking study from the Turku PET Center in Finland has revealed that changes in the brain’s opioid neurotransmitter system may play a key role in anorexia nervosa, a severe psychiatric disorder characterized by restricted eating, fear of weight gain, and body image disturbances. Published in Molecular Psychiatry on 12 January 2025, this research offers new insights into the biological mechanisms underlying this complex condition. 🔬 Key Findings: Elevated opioidergic tone was observed in the brains of individuals with anorexia nervosa compared to healthy controls. This system regulates appetite and pleasure, suggesting a potential link to the disorder’s hallmark symptoms. Interestingly, the brain’s glucose uptake remained similar in anorexia patients and healthy individuals, indicating the brain’s remarkable ability to protect its energy balance even under severe malnutrition. These findings may also explain the emotional symptoms (e.g., anxiety, depression) often associated with anorexia, as opioid activity is closely tied to mood regulation. 💡 Why This Matters: This study not only deepens our understanding of anorexia nervosa but also highlights the brain’s resilience in maintaining functionality despite physiological stress. It opens new avenues for targeted treatments that address the neurochemical imbalances contributing to the disorder. 🙏 Huge thanks to the collaborative efforts of researchers from the University of Turku, Turku University Hospital, and Pusan National University in South Korea for advancing our knowledge of this challenging condition. #MentalHealth #Neuroscience #AnorexiaNervosa #Research #BrainHealth #OpioidSystem #MentalHealthAwareness #ScienceMatters
Anorexia nervosa is associated with higher brain mu-opioid receptor availability - Molecular Psychiatry
nature.com
To view or add a comment, sign in
-
A recent Perspective Paper published by Prof. Heresco-Levy and Prof. Lerer in the journal of Molecular Psychiatry presents novel suggestions and clinical implications supported by compelling evidence, focusing on the synergistic treatment of neuropsychiatric disorders using serotonergic psychedelic (SP) and NMDAR modulator combination therapies. Preclinical studies performed in the Lerer laboratory have already shown that these combination treatments attenuate the head twitch response and therefore suggest reduction of psychotic-like effects in mice, warranting further investigation in human studies. Accumulating animal models and clinical data to date indicate that these therapies may suitably address major unmet medical needs such as treatment-resistant schizophrenia and depression. Negev Labs is proud to support the pioneering work of Prof. Bernard Lerer and his dedicated team at Hadassah Brainlabs Center for Psychedelic Research, which is a new initiative dedicated to developing novel neuroplastogens for the treatment of severe mental health disorders. #neuroplastogens #neuroscience #psychiatry https://lnkd.in/eMxVewuJ
Synergistic psychedelic - NMDAR modulator treatment for neuropsychiatric disorders - Molecular Psychiatry
nature.com
To view or add a comment, sign in
-
I am happy to announce the publication of my new book chapter titled: "Overactivation of Microglia as a Shared Pathophysiology in Different Neuropsychiatric Disorders." This chapter explores the critical role of microglia, the immune cells in the brain, in the development of disorders such as autism, schizophrenia, major depression, and bipolar disorders. In this work, I focused on the interplay between immunity and brain function, highlighting how excessive microglial activity could be harnessed to develop new, targeted treatments. It’s worth noting that many scientists believe there are shared pathophysiological mechanisms across various neuropsychiatric disorders, which could explain their overlapping symptoms. This idea inspired me to examine multiple psychiatric conditions in this chapter rather than focusing on just one. At my lab at Mercer University School of Medicine, my ultimate goal is to decode or further elucidate these shared mechanisms to identify effective, shared therapeutic approaches that can truly transform patients' lives. Here is the link to the Book Chapter https://lnkd.in/eMfKNmxH #microglia #neuropsychiatry #research
Overactivation of Microglia as a Shared Pathophysiology in Different Neuropsychiatric Disorders
link.springer.com
To view or add a comment, sign in
-
Revisiting My First Doctoral Paper from 2014: 𝗜𝗻𝘃𝗮𝘀𝗶𝘃𝗲 𝗥𝗲𝗰𝗼𝗿𝗱𝗶𝗻𝗴𝘀 𝗶𝗻 𝗢𝗖𝗗 𝗮𝗻𝗱 𝗗𝗲𝗽𝗿𝗲𝘀𝘀𝗶𝗼𝗻 It’s humbling to revisit my first doctoral paper, published in Molecular Psychiatry: Different patterns of local field potentials from limbic DBS targets in patients with major depressive and obsessive-compulsive disorder. This research, based on invasive recordings from deep brain stimulation (DBS) electrodes, offered a glimpse into the complex neural oscillations underlying psychiatric conditions. 𝗞𝗲𝘆 𝗳𝗶𝗻𝗱𝗶𝗻𝗴𝘀 𝗳𝗿𝗼𝗺 𝘁𝗵𝗲 𝘀𝘁𝘂𝗱𝘆: 1. Distinct Patterns: We observed significantly higher alpha power (8–14 Hz) in the bed nucleus of stria terminalis (BNST) in patients with major depressive disorder (MDD) compared to those with obsessive-compulsive disorder (OCD). 2. Symptom Correlation: Alpha activity correlated with depressive symptom severity in MDD but not with OCD, suggesting a potential link to mood regulation. 3. A Potential Biomarker: These oscillations hinted at a possible state marker for depressive symptoms, opening discussions about their role in adaptive DBS strategies. 𝗛𝗼𝘄 𝗠𝘆 𝗣𝗲𝗿𝘀𝗽𝗲𝗰𝘁𝗶𝘃𝗲 𝗛𝗮𝘀 𝗚𝗿𝗼𝘄𝗻 Looking back, I realize how much this research has been a stepping stone rather than a definitive answer. Recent studies have expanded our understanding, suggesting that enhanced alpha/theta activity might not be specific to one disorder but instead reflect shared anxiety or depressive comorbidities across psychiatric conditions. This broader perspective highlights the potential of 𝘁𝗵𝗲𝘁𝗮/𝗮𝗹𝗽𝗵𝗮 𝗼𝘀𝗰𝗶𝗹𝗹𝗮𝘁𝗶𝗼𝗻𝘀 𝗮𝘀 𝗮 𝘁𝗿𝗮𝗻𝘀𝗱𝗶𝗮𝗴𝗻𝗼𝘀𝘁𝗶𝗰 𝗯𝗶𝗼𝗺𝗮𝗿𝗸𝗲𝗿—one that could guide innovative therapies like closed-loop neuromodulation, targeting shared circuits of emotional dysregulation. I feel immense gratitude for the team that contributed to this work and the participants who trusted us with their time and experiences. Research is always a collective effort, and seeing these findings evolve into new possibilities for treatment is both rewarding and humbling. I’d love to hear your thoughts—how can shared biomarkers like these shape the future of psychiatric treatments? Let’s discuss! #Neuroscience #MentalHealthResearch #DBS #OCD #Depression #Neuromodulation #AlphaOscillations #Psychiatry #Innovation DOI: https://lnkd.in/ej5kyjBY
Different patterns of local field potentials from limbic DBS targets in patients with major depressive and obsessive compulsive disorder - Molecular Psychiatry
nature.com
To view or add a comment, sign in
-
Stanford Psychiatry's Sergiu Pasca has received a grant from the National Institute of Neurological Disorders and Stroke (NINDS) to examine the human cellular model of midline crossing to study developmental neurological disorders. "Progress in understanding neurological disorders has been hindered by a lack of access to live neural cells from patients for direct investigation," says Dr. Pasca. "We will build a novel stem cell-derived human assembloid model of midline crossing to study how human axons develop in human central nervous system development, and plan to systematically apply this platform to understand the cellular phenotypes and molecular mechanisms of genetic neurological developmental disorders." Read more: https://stan.md/4apS6sy
To view or add a comment, sign in
-
-
This new data enhances our understanding of psilocybin's brain mechanisms, boosting confidence in its therapeutic potential for severe conditions like anorexia nervosa, and marks a crucial step towards its inclusion in mental health treatments 👏 #PsilocybinResearch #MentalHealth #AnorexiaNervosa #Neuroscience #TherapeuticInnovation #psilocybin
Anorexia nervosa (AN) is a debilitating condition, and has one of the highest mortality rates among psychiatric disorders, driven by restrictive feeding and excessive exercise. This promising small trial suggests that psilocybin, the active ingredient in magic mushrooms, may help treat #AN by enhancing cognitive flexibility. This Monash University study led by Dr Claire Foldi, published in Molecular Psychiatry, found that psilocybin improves body weight maintenance and cognitive flexibility in an animal model. Understanding psilocybin’s mechanism could pave the way for targeted therapies. Congratulations to the Monash Biomedicine Discovery Institute team for this important work. #MentalHealth #AnorexiaNervosa #Psilocybin #CognitiveFlexibility #MedicalResearch #MonashUniversity #PsilocybinResearch https://lnkd.in/d-vf5imz
How psilocybin potentially works to reverse the cognitive rigidity that is the hallmark of anorexia
monash.edu
To view or add a comment, sign in
-
NEW RESULTS in Molecular Psychiatry: late-life cognitive dysfunction and depression have an overall biological effect detectable through gut microbiota. Could our gut microbiome hold the key to noninvasive diagnosis & prognosis? I am so excited to share the first of my three dissertation papers. Stay tuned to learn how these findings intersect with neural signatures in late life! https://lnkd.in/eUE6cTTN
Gut microbiome predicts cognitive function and depressive symptoms in late life - Molecular Psychiatry
nature.com
To view or add a comment, sign in
-
🌟 Excited to share our recent publication in Molecular Psychiatry! 🌟 "Transcriptome signatures of the medial prefrontal cortex underlying GABAergic control of resilience to chronic stress" In this study, we demonstrate that male, but not female, mice with disinhibited SST neurons exhibit stress resilience, characterized by resistance to chronic stress-induced transcriptomic changes in the mPFC. I am deeply grateful for Beni’s invaluable guidance and extend my heartfelt thanks to our amazing collaborators who made this work possible. Bernhard Luscher, Julia Botvinov, Deepro Banerjee, Santhosh Girirajan Check the paper out here: https://lnkd.in/gMC5EUs2
Transcriptome signatures of the medial prefrontal cortex underlying GABAergic control of resilience to chronic stress exposure - Molecular Psychiatry
nature.com
To view or add a comment, sign in