Dimond Iii: Image Quality and Dose Management For Digital Radiography
Dimond Iii: Image Quality and Dose Management For Digital Radiography
Final Report
H.P. Busch
Trier
2004
DIMOND III
Contract: FIGM-CT-2000-00061
Working Group:
Brüderkrankenhaus Trier
Germany
Lead Contractor:
Prof. Dr. H.P. Busch
Contents:
Annex 2: - Janalyser-CDRAD -
Quality Testing for
Digital Projection Radiography
(C. Schilz)
Annex 3: - Janalyser -
Constancy Testing for
Digital Projection Radiography
(C. Schilz)
Annex 5: Acknowledgements
Chapter I
Imaging methods have to solve diagnostic problems with sufficient quality and
certainty. The full spectrum of imaging methods (from ultrasound to MRI and
CT) has to be included in the discussion of suitable indications for projection
radiography. It must also be taken into account that alterations to the spectrum
of applications can change the value of a given imaging method from that of a
final diagnostic tool to that of a screening method, or a starting point for further
diagnosis.
5
other than ensuring it did not exceed a maximum level. The advantage of
pursuing the strategy of attempting to attain the highest image quality is the
fact that aside from specific diagnostic information, other useful and
unexpected additional information can also be obtained. The use of digital
imaging methods can also mean that dose values can be reduced over a
broad range -- sometimes with decreases in image quality, and sometimes
without. Dose and quality management now uses this potential along the
guidelines of the ALARA principle (As Low As Reasonably Achievable) to
implement the strategy of setting image quality and dose to fit the clinical
situation (“quality as good as necessary, not as good as possible – dose value
as low as possible”).
One parameter that can be varied over a broader range in digital radiography
than in film/screen radiography is the exposure dose value. Past experience
and research demonstrate that for flat detectors, the speed class of 800 is
sufficient for nearly all indications. The dose value of the speed class 200 is no
longer used. For many indications, speed class 1600 is suitable. The storage
phosphor technique’s potential for dose reduction is significantly lower.
6
Examples of the high, medium, and low quality classes for skeletal exposures
are:
Indications for these three dose level bands have been defined corresponding
to the European referral guidelines. Clinical problems have been assigned to
quality levels in “extended” referral guidelines(Chapter IV). Afterwards the
recommended image quality level was transferred to a choice of suitable
parameters for the specific imaging method.
One example resulting out of a comparative study (see chapter VI) is shown in
the following diagram:
Relation between image quality classes and dose for various on imaging
methods (speed class)
There must be intensive debate on the strategies and methods for optimising
and standardising image quality in the future. Although many individual studies
(see references) describe interesting results, they are missing a methodical
framework.
As a first approach, exposure parameters (focus size, voltage, grid, and so on)
and projection can be chosen as for film/screen exposures. Future research
projects on digital radiography will exhaust the existing potential for further
optimisation.
7
Past experience shows that optimal post-processing is not independent of the
dose range. Therefore, optimisation strategies depend on the organ field, the
clinical problem and the required image quality class. Optimisation must be
carried out according to clinical criteria. Experience of many years shows that
optimisation according to “physical test phantoms” is not possible. However,
test phantom images (such as CDRAD2.0) are well suited for objectivation and
standardisation of image quality.
A digital test pattern should be integrated into a corner of the raw images to
demonstrate the influence of individual post-processing (in additional to
standard post-processing). This test pattern should combine high and low
contrast structures. The same kind of post-processing should be applied to
both the whole image and the test pattern. The results of this individual post-
processing can then be demonstrated on laser film or on a monitor.
8
The Future Aspects for “Digital Projection Radiography”
2. Both storage phosphor plates and flat detectors are well suited to the
spectrum of digital projection radiography. Flat detectors have better
imaging capabilities, storage phosphor systems lower costs.
5. Image quality and dose management strategies must take into account the
complete diagnostic chain, from the referral indication to the quality of
diagnosis.
6. The application of the ALARA principle means that the image quality
should be as good as necessary, not as good as possible. That means that
the dose value should be as low as possible and consistent with the clinical
objective.
9
11. The development of new strategies of optimisation and standardisation is a
challenge for the next years.
10
Chapter II
11
New or improved methods of digital projection radiography must fulfil the
following criteria:
12
In the following, five techniques are described:
13
3. Digital radiography with the selenium drum technique
Here, the detector consists of a rotating drum covered with selenium.
Selenium is a semiconductor which becomes conductive by absorbing x-ray
radiation. The selenium layer of the drum is positively charged homogeneously
before exposure. During the exposure, charges are equalised, that is, the
positive charge is reduced. This creates a charge pattern on the surface that is
proportional to the radiation pattern. The charge pattern is scanned during
drum rotation and converted to digital image information (8).
A glass plate is coated with a layer of amorphous silicon (thickness 500 µm).
The structure is as a matrix of silicon photodiodes similar to the CCD detector.
A switching transistor selected by a control line is connected to the element
(pixel). A scintillator layer with caesium iodine is in front of the silicon
elements. Within this layer the x-ray quanta are converted to light quanta. The
needle-structured caesium iodine crystals focus the light quanta to the detector
elements. The charge of the specific photodiode is read out and transferred to
an analogue/digital converter (14, 15).
14
Imaging capabilities of systems for digital projection radiography
Spatial resolution
Dynamic range
Quantum efficiency (DQE)
Modular transfer function (MTF)
Spatial resolution:
The parameter spatial resolution describes the detectability of small, high-
contrast objects. Spatial resolution is usually demonstrated by a lead bar
pattern and measured as linepairs per millimetre (lp/mm). Scattering inside the
detector has a significant influence on resolution, similar to film/screen
exposures. For analogue systems, the maximum resolution is determined by
the evaluation of the image of the lead bar pattern. The cut-off resolution is
defined as 4% of the maximal amplitude of the modulation transfer function
(MTF). For digital systems, there exists an additional limitation by pixel size.
The scanning formula means that for a pixel size of a, the maximal transfer
frequency can be 1/2a. A pixel size of 0.25 mm, therefore, would lead to a cut-
off frequency (Nyquist cut-off) of 2 lp/mm. If this limitation is exceeded by a
lead bar pattern image, an aliasing pattern will result, with a reduction of image
quality.
Dynamic range:
The dynamic range is determined by the dose range, which can be imaged
without the effects of underexposure or overexposure. Digital systems have a
linear correlation between dose value and signal amplitude. Conventional
film/screen systems have only a narrow dynamic range for imaging that is
characterized by the linear perform of s-shaped density curve. A large dynamic
range is connected to a broad range for the exposure parameter dose (e.g.
bedside imaging (reduction of the number of retakes!)). It allows simultaneous
imaging of large absorption differences (e.g. bone/soft tissue:
mediastinum/parenchyma of the lung) within only one exposure (reduction of
dose value!).
15
Detective quantum efficiency (DQE):
DQE describes the efficiency of x-ray quanta-to-signal conversion. The DQE
depends on the dose value and the spatial resolution (object size) and is
influenced by the quantum noise and the noise of the detector. An ideal
detector has a DQE=100%. A high DQE is correlated with a high effective use
of x-ray quanta. This results in a reduction of dose value without loss of image
quality.
Image quality:
The image quality at the end of the imaging chain (laser film, monitor) is
determined by the parameters already described, with the addition of digital
post-processing. Post-processing can lead to increased image quality and
additional diagnostic information. Image processing should result in improved
detail contrast, edge enhancement, reduction of dynamic range and noise
(19).
16
position, projections and vessels. The II entrance dose for fluoroscopy is 0.02
µGy/sec (3 pulses/sec, II 27cm) and 0.17 µGy/sec (continuous beam, II 27
cm). Pulsed fluoroscopy, image integration (recursive filtering) and collimation
without radiation is the major potential of dose reduction.
The selenium drum technique is used in dedicated systems for the lung.
(Philips: Thoravision). For an image format of 35x43 cm (matrix: 2166x2448),
the pixel size is 0.2mm and the corresponding cut-off frequency 2.5 lp/mm.
The dynamic range is higher than 1:10.000. The DQE of 60% (60 kV) points to
the possibility of dose reduction from that of film/screen (DQE 20%).
For a detector area of 35x43 cm (matrix 2560x3072), the pixel size is 0.139
mm and the cut-off resolution 3.6 lp/mm. The DQE is 43% (70kV, 0 lp/mm)
and the dynamic range >1:10.000.
17
Flat detector with indirect conversion (scintillator)
Today, image intensifier, storage phosphor and selenium drum radiography all
play an important role in projection radiography as it is used every day.
18
There are similar problems associated with the increase in matrix size from
2000 to 4000 for storage phosphor radiography (22). Increasing the matrix size
makes sense only if it results in increased diagnostic information. The image
quality of state-of-the-art II units should be considered to be sufficient because
of its being able to be applied to all existing clinical situations. Further
innovation is likely to focus on reducing the dose (pulsed fluoroscopy,
collimation without radiation) and improving handling rather than improving the
image quality itself.
Because the digital image intensifier technique can already be integrated into
PACS systems, there is no strong need for new detectors in fluoroscopic units
when compared to projection radiography as a whole. But the first applications
of flat detectors for single exposures and fluoroscopy show promising results.
Flat detector fluoroscopy’s potential of improving image quality is greater than
its potential to reduce dose. The signal-to-noise ratio is still lower in the low
dose range in comparison to II units (23). It is, however, likely that image
intensifiers will be replaced by this flat detector technique in the future.
As can be read in current literature (24, 25) and the results of a consensus
conference (26), the storage phosphor technique can be applied to all clinical
situations requiring projection radiography. One excellent field of application is
bedside imaging without automatic exposure control. The large dynamic range
guaranties a constantly high image quality. However, early expectations for a
significant reduction of dose value (in comparison to film/screen) didn’t hold.
The necessary dose level is between the speed class 200 and 400. Handling
of the storage phosphor technique is disadvantageous, because exposed
cassettes have to be brought to a central reading unit and erased cassettes
have to be carried back to the exposure room. Storage phosphor radiography
is the only method for bedside imaging because all other detector techniques
are restricted to a fixed examination room. Currently, the only way to conduct
horizontal beam imaging at Bucky tables is the storage phosphor technique.
An alternative to this would be C-arm units, which are not marketed by all
manufacturers. A flat detector which can be read out like a mobile cassette is
expected in the near future. However, innovation to the detective material of
storage phosphor plates (with needle configuration) and a faster readout by
detection of the information line by line could result in improved image quality
and handling. First attempts to read out the plate just at the exposure unit
could lead to competition with flat detectors (that is, in terms of cost).
19
Selenium drum technique
Clinical studies have shown that, based on the better imaging capabilities of
selenium detectors, the selenium drum technique is more favourable for lung
units than the storage phosphor technique (22). The literature describes the
ways in which doses can be reduced. One disadvantage of the selenium drum
technique is that the units for selenium technique can be used only for thoracic
imaging in an upright position, requiring a high frequency of these
examinations. It is assumed that flat detectors for Bucky tables and wall stands
will play a greater role in the future and will probably replace the selenium
drum technique.
CCD technology
Until now, only a limited number of reports of clinical results for this technology
have been published. Based on its imaging capabilities, CCD technology
probably produces similar image quality to storage phosphor radiography for
the same dose value. A significant reduction of dose cannot be expected
because of the limited DQE. CCD technology does, however, have the
advantageous of no cassettes having to be carried.
Flat detectors with scintillators demonstrated higher image quality and a lower
dose level compared to film/screen and storage phosphor radiography (27, 28,
29, 30).
The new potential of digital projection radiography can be discussed from the
standpoint of a single stand-alone unit without integration into a digital system
or from the standpoint of a necessary component for PACS (picture archiving
and communication system) systems. For the near future, the view from a
stand alone unit will remain more common. The option of integration into a fully
digital system, with its many advantages (transfer, archiving, post-processing)
is an important aspect of this new digital technique. X-ray units for projection
20
radiography are part of radiologists’ tools; image quality thus has to fulfil the
diagnostic demands – not more and not less. An increase of image quality
beyond these clinical demands is useless as it costs money and also requires
higher doses. New discussion of the quality of new imaging methods must be
based on the 100 years of experience with film/screen radiography, 25 years
of experience with digital image intensifier radiography and 20 years of
experience with storage phosphor radiography that the industry has. A suitable
spectrum of indications has been discussed in a large number of publications
and a consensus conference. Image quality is defined by physical
measurements (spatial resolution, MTF, DQE, homogeneity) and clinical
studies comparing different methods. Initial results of the new flat detector
systems demonstrate the potential to increase image quality and to decrease
dose values. It cannot be foreseen whether this will be connected to a
broadening of the spectrum of referral indications.
There is a close correlation between dose and image quality. The commonly
known image quality and radiation protection requirements are leading to new
strategies for dose reduction. One way of achieving this could be a higher
image quality with the same dose; another way the same image quality with a
lower dose value. In the past, the focus has been more on image quality;
today, however, dose reduction, easy handling and a favourable cost/benefit
relation are important decision criteria. Better image quality is only useful if it
has consequences on the outcome of therapy and follow-up and reduces the
number of additional examinations.
Discussion of the financial aspects is difficult in light of the high purchase and
service costs and the need for specific IT infrastructure. The costs for a flat
detector system are three times as high as a film/screen Bucky table with wall
stand. For a stand alone unit, the potential of cost reduction lies in time and
personnel costs (increase of throughput, reduction of personnel costs) and in a
reduction of film costs (smaller film size, no retakes, lower number of films).
The reduction of patient risk cannot, however, be calculated in terms of
economics. The cost/benefit relation of a PACS system is also very difficult to
calculate and largely depends on the requirements placed on the examinations
themselves, the system and personnel.
Further clinical experience must now show whether this new potential will lead
to a new examination workflow and to a new spectrum of referral indications.
Higher costs demand an intensive discussion of cost/benefit relation. The
physical imaging capabilities of flat detectors point to the possibility of a
successful introduction into every-day clinical world in the near future.
21
References:
[1] Busch HP, Lehmann KJ, Freund MC, Georgi (1991). Digitale
Projektionsradiographie. Röntgenpraxis 44: 329-335
[2] Busch HP, Lehmann KJ, Freund MC, Georgi M (1992). Digitale
Projektionsradiographie: Klinische Anwendungsmöglichkeiten.
Röntgenpraxis 45: 35-43
[3] Frija G (1999) Flat Panel Sensors: Questions and Answers. Medical
Imaging Techhnology, Vol 17, 2: 99 – 104
[4] Chotas HG, Dobbins JT, Ravin CE(1999). Principles of digital
radiography with large-area, electronically readout detectors: A review of
the basics. Radiology 210: 595 – 599
[5] Vetter S, Heckmann H, Strecker EP, Busch HP, Kamm KF,
Allmendinger H(1998). Klinische Aspekte zu Bildqualität und Dosis bei
gittergesteuerter gepulster Durchleuchtung. Akt.Radiol. 8: 191 – 195
[6] Vetter S, Faulkner K, Strecker EP, Busch HP (1998) Dose reduction and
image quality in pulsed fluoroscopy. Radiation Protection Dosimetry. 80:
299 – 301
[7] Busch HP, Hoffmann HG, Kruppert H, Mörsdorf M(1997). Digitale BV-
Radiography – Eine Methode hat sich durchgesetzt. Electromedica 65:
62 – 64
[8] Neitzel U (1993). Selenium: a new image detector for digital chest
radiography. Medica Mundi 38: 89 – 93
[9] Gotsch K (1998) Röntgendiagnostik ohne Film. F&M 106: 448-450
[10] Lee DL, Cheung LK, Jeromin LS, Palecki E (1996). Imaging
performance of a direct digital radiographic detector using selenium and
a thin film transistor array. In: Lemke HU(ed) Computer assisted
Radiology. Elesevier: 41 – 46
[11] Lee DL, Cheung LK, Jeromin LS (1995). A new digital detector for
projection radiography. SPIE 2432: 237 – 249
[12] Shaber GS, Maidment ADA, Bell J, Jeromin LS, Lee DL, Powell GF
(1997) Full field digital projection radiography system: Principles and
image evaluaten. In: Lemke HU (ed) Computer assisted radiology and
surgery. Elsevier: 1 – 7
[13] Yaffee MJ, Rowlands JA (1997) X-ray detectors for digital projection
radiography. Phys Med Biol: 1 - 39
[14] Chaussat Ch, Chabbal J, Ducourant Th, Spinnler V, Vieux G, Neyret R
(1998) New CsJ/a-Si X-ray flat panel detector provides superior
detectivity and immediate direct digital output for General Radiography
systems.
SPIE 3336: 45 – 56
[15] Neitzel U(1999) Integrated digital radiography with a flat –panel sensor.
Medical Imaging Technology 17,2: 123-129
[16] Neitzel U (1998) Grundlagen der digitalen Bildgebung. In Ewen K(Hrsg)
Moderne Bildgebung. Georg Thieme: 71 – 76
22
[17] Neitzel U(1998) Systeme für die digitale Bildgebung. In: Ewen K (Hrsg)
Moderne Bildgebung. Georg Thieme: 127 – 135
[18] Kamm KF (1998) Grundlagen der Röntgenabbildung. In: Ewen E (Hrsg)
Moderne Bildgebung. Georg Thieme: 45 – 60
[19] Prokop M, Schaefer-Prokop CM(1997) Digital image processing. Eur
Radiol 7(Suppl3): 73 – 82
[20] Vuysteke P, Schoeters E (1994) Multiscale image contrast amplification
(MUSICA). SPIE 2167: 551 – 560
[21] Lehmann KJ, Busch HP, Georgi M (1992) Digitale Bildverstärker
Radiographie – welche Aufnahmedosis für welche Fragestellung? Akt
Radiol 2:11 – 15
[22] Schaefer-Prokop CM, Prokop M (1996) Digitale Radiographie des
Thorax – der Selendetektor im Vergleich zu anderen
Abbildungssystemen.
Kontraste: 14 – 22
[23] Bruijns TJC, Alving PL, Bury R, Cowen AR, Jung N, Luijendijk HA,
Meulenbrugge HJ, Stouten HJ (1998) Technical and clinical results of an
experimental FLat Dynamic (digital) X-ray image Detector (FDXD)
system with real-time corrections. SPIE 3336: 33 – 44
[24] Busch HP (1997) Digital radiography for clinical application. Eur Radiol 7
(Suppl 3): 66 – 72
[25] Leitlinien der Bundesärztekammer zur Qualitätssicherung in der
Röntgendiagnostik (1995) Deutsche Ärzteblatt 92, 49: 1691 – 1703
[26] Busch HP, Klose KJ, Braunschweig R, Neugebauer E (1999) Digitale
Radiographie – Ergebnisse einer Anwendungsumfrage und einer
Konsensuskonferenz. Akt.Radiol. 7: 56 – 63
[27] Hamers S, Freyschmidt J (1998) Digital radiography with an electronic
flat-panel detector: First clinical experience in skeletal diagnostics.
Medica Mundi 42,3: 2 – 6
[28] Reiff KJ (1999) Flat panel detectors – closing the (digital) gap in Chest
and skeletal radiology. European Journal of Radiology (in press)
[29] Strotzer M, Gmeinwieser J, Völk M, Fründ R, Feuerbach S (1999)
Digitale Flachbilddetektortechnik basierend auf Cäsiumjodid und
amorphem Silizium: Experimentelle Untersuchungen und erste klinische
Ergebnisse. Fortschr Röntgenstr 170: 66 – 72
[30] Strotzer M, Gmeinwieser J, Völk M, Fründ R, Seitz J, Manke C, Albricht
H, Feuerbach S (1998) Clinical application of a flat-panel X-ray detector,
based on amorphous silicon technology: image quality and potential for
radiation dose reduction in skeletal radiography. Amer J Roentgenol
171: 23 – 27
23
Chapter III
Based on:
24
Content:
1) Chest/lungs and heart PA projection, wall stand
2) Chest/lungs and heart Lateral projection, wall stand
3) Chest/lungs and heart AP projection, bedside
4) Cervical spine AP projection, grid table or vertical stand
5) Cervical spine Lateral projection, grid table or vertical stand
6) Thoracic spine AP projection, grid table or vertical stand
7) Thoracic spine Lateral projection, grid table or vertical stand
8) Lumbar spine AP projection, grid table or vertical stand
9) Lumbar spine Lateral projection, grid table or vertical stand
10) Pelvis AP projection, grid table or vertical stand
11) Skull AP projection, grid table or vertical stand
12) Skull Various projections, grid table or vertical stand
13) Extremity I Various projections, grid table or vertical stand
Hip
Thigh
14) Extremities II Various projections, grid table or vertical stand
Shoulder
Upper arm
Ribs
Sternum
Knee joint
Lower leg
15) Extremities III Various projections, grid table or vertical stand
Elbow
Forearm
Ankle
Tarsus
16) Extremities IV Various projections, grid table or vertical stand
Hand
Fingers
Foot
Toes
17) Abdomen AP projection, grid table or vertical stand
25
Chest/lungs and heart - PA projection, wall stand
Image criteria
Performed at full inspiration (as assessed by the position of the ribs above the
diaphragm - either 6 anteriorly or 10 posteriorly) and with suspended
respiration
Symmetrical imaging of the thorax, as shown by the central position of a
spinous process between the medical ends of the clavicles
Medical border of the scapulae to be outside the lung fields
Visualisation of the whole lung including the costophrenic angles
Clear visualisation of the lung structure and vascular pattern throughout the
lung fields including the retrocardiac area
Clear delineation of vertebral disc spaces
26
Chest/Lungs and Heart - lateral projection, wall stand
Image criteria
Performed at full inspiration and with suspended respiration
Arms should be raised clear of the thorax
Superimposition of the posterior lung borders
Visualisation of the trachea
Visualisation of costophrenic angles
Visually sharp reproduction of the posterior border of the heart, aortic arch,
mediastinum, diaphragm, sternum and thoracic spine
27
Chest/ Lungs and Heart - AP projection, bedside
Image criteria
Imaging of the whole rib cage above the diaphragm and both hemidiaphragms
at full inspiration (if possible)
The mediastinum should be sufficiently penetrated to visualize trachea and
major bronchi.
Visualisation of venous catheters, draining catheters… including the tip
Visually sharp reproduction of the vascular pattern
Alternative
Anti-scatter grid: No
FFD: 100 cm
Radiographic voltage: 80 - 90 kV
28
Cervical Spine - AP projection
Image criteria
Complete imaging of the cervical spine, including the upper cervical spine and
the 7th vertebra, if necessary with additional spotfilm
Visually sharp imaging, as a single line, of the upper and lower-plate surface in
the centred beam area
Visualisation of the intervertebral joints and the spinous processes
Visually sharp imaging of the cortical and trabecular structures
29
Cervical Spine - lateral projection
Image criteria
Complete imaging of the cervical spine, including the upper cervical spine and
the 7th vertebra
Visually sharp imaging, as a single line, of the upper and lower-plate surface in
the centred beam area
Visualisation of the intervertebral spaces, intervertebral joints and spinous
processes
Visualisation of the soft tissues, particularly the retrotracheal space
Visually sharp imaging of the cortical and trabecular structures
30
Thoracic Spine - AP projection
Image criteria
Complete imaging of the thoracic spine, including Th1
Visually sharp imaging, as a single line, of the upper and lower-plate surface in
the centred beam area
Visually sharp imaging of the pedicle, spinous processes and costovertebral
joints
31
Thoracic Spine - lateral projection
Image criteria
Complete imaging of the thoracic spine from T2 down to the thoracolumbar
junction
Visually sharp imaging, as a single line, of the upper and lower-plate surface in
the centred beam area
Visualisation of the intervertebral spaces and intervertebral joints in the
centred beam area
Visually sharp imaging of the cortical and trabecular structures
32
Lumbar Spine - AP projection
Image criteria
Complete visualisation of the lumbar spine and sacrum
Visually sharp imaging, as a single line, of the upper and lower-plate surfaces
in the centred beam area
Visualisation of the intervertebral spaces in the centred beam area
Visually sharp imaging of the pedicles, transverse processes, spinous
processes and intervertebral joints
Visualisation of the sacroiliac joints
Visually sharp imaging of the cortical and trabecular structures
33
Lumbar Spine - lateral projection
Image criteria
Complete visualisation of the lumbar spine and lumbosacral junction
Visually sharp imaging, as a single line, of the upper and lower-plate surface in
the centred beam area
Visualisation of intervertebral spaces, intervertebral joints and spinous
processes
Visually sharp imaging of the cortical and trabecular structures
34
Pelvis - PA projection
Image criteria
Symmetrical imaging of both sides of the pelvis
Visually sharp imaging of the necks of the femora – should not be distorted by
foreshortening or rotation
Visually sharp imaging of the pubic and ischial rami and the sacroiliac joints
Visually sharp imaging of the cortial and trabecular structures including the
trochanters
Visually sharp imaging of the sacrum and its intervertebral foramina
35
Skull - PA projection
Image criteria
Symmetrical reproduction of the skull, particularly cranial vault, orbits and
petrous bones
Projection of the apex of the petrous temporal bone into the centre of the orbits
Visually sharp reproduction of the frontal sinus, ethmoid cells and apex of the
petrous temporal bones and the internal auditory canals
Visually sharp reproduction of the outer and inner lamina of the cranial vault
36
Skull - lateral projection
Image criteria
Visually sharp reproduction of the outer and inner lamina of the cranial vault,
the floor of the sella, and the apex of the petrous temporal bone
Superimposition respectively of the contours of the frontal cranial fossa, the
lesser wing of the sphenoid bone, the clinoid processes and the external
auditory canals
Visually sharp reproduction of the vascular channels, the vertex of the skull
and the trabecular structure of the cranium
Superimposition of the mandibular angles and ascending rami
37
Extremities I - Various projections, grid table or vertical stand
Hips
Thighs
Image criteria
Visualisation of typical structures of compacta and spongiosa
Imaging of the joints in typical projections
Visually sharp reproduction of the cortical joint surface
38
Extremities II - Various projections, grid table or vertical stand
Shoulder
Upper arm
Ribs
Sternum
Knee joint
Lower leg
Image criteria
Visualisation of typical structures of compacta and spongiosa
Imaging of the joints in typical projections
Visually sharp reproduction of the cortical joint surface
39
Extremities III - Various projections, grid table or vertical stand
Elbow
Forearm
Ankle
Tarsus
Image criteria
Visualisation of typical structures of compacta and spongiosa
Imaging of the joints in typical projections
Visually sharp reproduction of the cortical joint surface
40
Extremities IV - Various projections, grid table or vertical stand
Hands
Fingers
Feet
Toes
Image criteria
Visualisation of typical structures of compacta and spongiosa
Imaging of the joints in typical projections
Visually sharp reproduction of the cortical joint surface
41
Abdomen - PA projections, grid table or vertical stand
Image criteria
Reproduction of the area of the whole abdomen from the diaphragm to the
base of the bladder
Reproduction of the kidney outlines
Visualisation of the psoas outlines
Visually sharp reproduction of the bones
42
Guidelines and user-defined recommendations for the
selection of imaging parameters
Based on:
43
44
45
46
47
48
49
50
51
Chapter IV
Quality and dose management should start with establishing a clear definition
of indications for Digital Projection Radiography. These guidelines should be
based on the criteria and methods of evidence-based medicine, taking into
account the clinical situation and the risk for to the patient. The aim is to avoid
unnecessary, routine exposures as well as to reduce the dose per image. Two
documents can be considered a starting point here, namely “Referral
Guidelines for Imaging”, published by the European Commission (European
Commission – Radiation protection 118 – ISBN 92-828-9452-5). and the
Council Directive 97/43/ Euratom on health protection of individuals against
dangers of ionizing radiation in relation to medical exposure. The latter
publication includes sections on purpose and scope, definitions, justification,
optimisation and responsibilities.
One parameter that can be varied over a broader range in digital radiography
than in film/screen radiography is the exposure dose value. Past experience
and research demonstrate that for flat detectors, the speed class of 800 is
sufficient for nearly all indications. The dose value of the speed class 200 is no
longer used. For many indications speed class, 1600 is suitable. The storage
phosphor technique’s potential for dose reduction is significantly lower.
52
One example resulting out of a comparative study (see chapter VI) is shown in
the following diagram:
53
Examples of quality classes high, medium and low:
INVESTIGATION {DOSE}
XR Plain radiography one or more films
CXR Chest radiograph
Typical effective
Class Examples
Dose (mSv)
0 0 US, MRI
I <1 CXR, limb XR, pelvis XR
IVU, lumbar spine XR, NM
II 1–5
(e.g. skeletal scintigram), CT head & neck
III 5–10 CT chest and abdomen, NM (e.g. cardiac)
IV >10 Some NM studies (e.g. PET)
QUALITY CLASS
H High
M Middle
L Low
RECOMMENDATION {GRADE}
(A) Randomised controlled trials (RCTs), metaanalyses, systematic reviews; or
(B) Robust experimental or observational studies; or
(C) Other evidence where the advice relies on expert opinion and has the
endorsement of respected authorities.
54
QUALITY - DOSE
- LEVEL RECOM-
INVESTI-
CLINICAL MEN-
GATION COMMENT
Madrid
Dublin
Athen
PROBLEM DATION
Trier
{DOSE}
{GRADE}
A. Head
Especially for those who have worked with
Orbits
XR orbits (I) H H H H Indicated (B) metallic materials, power tools, etc. Some centres
Metallic FB (before MRI)
use CT. (see Trauma Section K for acute injury).
XR skull, sinus C Not indicated Radiography of little use in the absence of focal
Headache: chronic M M M M
spine (I) routinely (B) signs/symptoms. See A13 below.
B. Neck (for the spine see Sections C [The spine] and K [Trauma])
Soft tissues
Specialised Radiographs will demonstrate bony abnormalities,
Temporo-mandibular joint
XR (I) M H M-H M investigation but are normal in great majority, as problems are
dysfunction
(B) usually related to articular disk dysfunction.
C. The spine
General (for trauma see Section K)
Specialised
e.g. Full-length standing radiograph for scoliosis.
Congenital disorders XR (I) L L L L investigation
See Section M for back pain (M10).
(C)
Cervical spine
A single lateral cervical spine XR with the patient
in subluxation supervised comfortable flexion
should reveal any significant subluxation in
Possible atlanto-axial
XR (I) M M M-H M Indicated (C) patients with rheumatoid arthritis, Down’s
subluxation
Syndrome, etc. MRI (flexion/extension) shows
effect on cord when XR positive or neurological
signs present.
55
Degenerative changes begin in early middle-age
and are often unrelated to symptoms which are
Neck pain, brachalgia, Not indicated
XR (I) M M M M usually due to disk/ligamentous changes
degenerative change routinely (B)
undetectable on plain XR. MRI increasingly being
used, especially when brachalgia is present.
Thoracic spine
Degenerative changes are invariable from middle-
age. Examination rarely useful in the absence of
Not indicated neurological signs or pointers to metastases or
Pain without trauma:
XR (I) M M M M routinely (B) infection. Consider more urgent referral in elderly
degenerative disease
onwards. patients with sudden pain to show osteoporotic
collapse or other forms of bone destruction.
Consider NM for possible metastatic lesions.
Lumbar spine
Degenerative changes are common and non-
Chronic back pain with no
Not indicated specific. Main value in younger patients (e.g.
pointers to infection or XR (II) M M M M
routinely (C) younger than 20, spondylolisthesis, ankylosing
neoplasm
spondylitis, etc.) or in older patients e.g. >55.
D. Musculoskeletal system
The 2–3 phase skeletal scintigram is more
sensitive than XR. However, findings are not
XR (I) + NM (II) specific and further specialised NM with
Osteomyelitis M H M M Indicated (B)
or MRI (0) alternative agents may be needed. Fat-
suppressed MRI is becoming regarded as the
optimal investigation.
Primary bone tumour XR (I) H H H H Indicated (B) XR may characterise the lesion.
Bone pain XR (I) M M M M Indicated (B) Local view of symptomatic areas only.
56
In patients with suspected rheumatoid arthritis,
XR (I) hands/feet H H H H Indicated (C) XR feet may show erosions even when
symptomatic hand(s) appear normal.
Specialised
Hallux valgus XR (I) L L L L investigation For assessment before surgery.
(C)
E. Cardiovascular system
CXR must not delay admission to a specialised
unit. CXR can assess heart size, pulmonary
oedema, etc. and can exclude other causes.
Central chest pain Department film preferable. Subsequent imaging
CXR (I) M M M M Indicated (B)
myocardial infarction involves specialised investigations (NM, coronary
angiography, etc.) and depend on local policy. NM
offers myocardial perfusion and ventriculography
data. Increasing E1 interest in MRI.
Suspected valvular CXR (I) and Used for initial assessment and when there is a
M M M M Indicated (B)
cardiac disease cardiac US (0) change in the clinical picture.
57
Follow-up of patients with Only if signs or symptoms have changed, when
Not indicated
heart disease or CXR (I) M M M M comparison with the CXR obtained at presentation
routinely (B)
hypertension may be helpful.
F. Thoracic system
Conditions such as Tietze’s disease show no
Not indicated
Non-specific chest pain CXR (I) M M M M abnormality on CXR. Main purpose is
routinely (C)
reassurance.
Not indicated Showing a rib fracture after minor trauma does not
Chest trauma CXR (I) M M M-H M
routinely (C) alter management (see Trauma Section K).
Chronic obstructive
Not indicated
airways disease or CXR (I) M M M M Only if signs or symptoms have changed.
routinely (B)
asthma; follow-up
G. Gastrointestinal system
Gastrointestinal tract
CXR may be sufficient, unless localisation for
Oesophageal perforation CXR (I) M M M M Indicated (B)
surgical repair is planned.
Inflammatory bowel
AXR (II) L M M-H L Indicated (B) Often sufficient for evaluation.
disease of colon
58
Local policy will determine strategy. Supine AXR
Acute abdomen pain;
(for gas pattern, etc.) is usually sufficient. Erect
(warranting hospital AXR (II) plus
L M M L Indicated (B) AXR not indicated routinely. Increasing use of CT
admission and surgical erect CXR (I)
as a ‘catch- all’ investigation here. US widely used
consideration)
as a preliminary survey.
Not indicated
Palpable mass AXR (II) L L M L
routinely (C)
59
K. Trauma
Head: general
Head: low risk of intracranial injury
• Fully orientated
• No amnesia These patients are usually sent home with head
• No neurological defects Not indicated injury instructions into the care of a responsible
SXR (I) M M M M
• No serious scalp routinely (C) adult. They may be admitted to hospital if no such
laceration adult is available.
• No haematoma
XR Mandible (I)
Mandibular trauma or orthopantomo- M M M M Indicated (C) For non-traumatic TMJ problems see B11.
gram (OPG) (I)
Cervical spine
In those who meet all of the following criteria:
Conscious patient with
Not indicated (1) Fully conscious (2) Not intoxicated (3) No
head and/or face injury XR C spine (I) M M M M
routinely (B) abnormal neurological findings.
only
(4) No neck pain or tenderness.
60
Cervical spine XRs can be very difficult to
evaluate. Radiography also difficult
1. Must show C7/T1.
Neck injury: with pain XR C spine (I) H H H H Indicated (B) 2. Should show odontoid peg (not always possible
at time of initial study)
3. May need special views, CT or MRI especially
when XR equivocal or complex lesions.
Neck injury: with pain but Views taken in flexion and extension (consider
XR C spine; Specialised
XR initially normal; fluoroscopy) as achieved by the patient with no
flexion and M M M M investigation
suspected ligamentous assistance and under medical supervision. MRI
extension (I) (B)
injury may be helpful here.
Upper limb
Some dislocations present subtle findings. As a
minimum, orthogonal views are required. US, MRI
Shoulder injury XR shoulder (I) M M M M Indicated (B)
and CT arthrography all have a role in soft tissue
injury.
Lower limb
Especially where physical signs of injury are
minimal. Inability to bear weight or pronounced
Knee injury Not indicated bony tenderness, particularly at patella and head
XR knee (I) M M M M
(fall/blunt trauma) routinely (B) of fibula, merit radiography. CT/MRI may be
needed where further information is required (see
D23).
61
Features which justify XR include age ( elderly
Not indicated
Ankle injury XR ankle (I) M M M M patients), malleolar tenderness, marked soft tissue
routinely (B)
swelling and inability to bear weight.
Soft tissue injury: Not indicated Plastic is not radio-opaque, wood is rarely radio-
XR (I) M M M-H M
FB (plastic, wood) routinely (B) opaque.
Chest
Not indicated The demonstration of a rib fracture does not alter
Chest trauma: minor CXR (I) M M M M
routinely (B) management.
62
Indicated (C) In addition to CXR. Think of thoracic
Sternal fracture XR lateral M M M M Indicated (C)
spinal and sternum (I) aortic injuries too.
Major trauma
Stabilise patient’s condition as a priority. Perform
only the minimum XRs necessary at initial
Major trauma — general C-spine XR (I), assessment. C-spine XR can wait as long as
screen on unconscious or CXR (I), pelvis M M M M Indicated (B) spine and cord suitably protected, but CT C-spine
confused patient XR (I), may be combined with CT head. Pelvic fractures
often associated with major blood loss. See Head
Injury K1–K4.
L. Cancer
Lung
CXR PA and Lat But can be normal, particularly with central
Diagnosis M M M M Indicated (B)
(I) tumours.
Bladder
To assess kidneys and ureters for further
Staging IVU (II) M M M M Indicated (B)
urothelial tumours.
Musculoskeletal tumours
Imaging and histology complementary. Best
Diagnosis XR (I) + M M M M Indicated (B) before biopsy: See Musculoskeletal Section D.
NM needed to ensure that lesion is solitary.
M. Paediatrics
Minimise x-irradiation in children, especially those with long term problems
(for head injury in children see Trauma Section K)
CNS
Abnormal head US indicated where anterior fontanelle is open.
Specialised
appearance — Where sutures are closed/closing. MRI indicated
SXR (I) M M M M investigation
hydrocephalus — odd for older children. (CT may be appropriate if MRI
(C)
sutures not available).
Not indicated
Epilepsy SXR (I) M M M M Poor yield.
routinely (B)
Hydrocephalus —shunt
XR (I) M M M M Indicated (B) XR should include whole valve system.
malfunction (see A10)
63
Neck and spine — For trauma see Section K
Deformity is usually due to spasm with no
significant bone changes. If persistent, further
Torticollis without trauma XR (I) L L L L Not indicated
imaging (e.g. CT) may be indicated following
consultation.
Not indicated
Hairy patch, sacral dimple XR (I) L L L L May be helpful in older children.
routinely (B)
Musculoskeletal
Local policies will apply; close clinical/radiological
liaison essential. Skeletal survey for those under
Non accidental injury —
XR (I) of two injury see Section K) years after clinical
child abuse (for head M M M M Indicated (B)
affected parts consultation. May occasionally be required in the
injury see Section K)
older child. CT/MRI of brain may be needed, even
in the absence of cranial apparent injury.
Cardiothoracic
Initial and follow-up films are indicated in the
presence of persisting clinical signs or symptoms
Not indicated
Acute chest infection CXR (I) M M M M or in the severely ill child. Consider the need for
routinely (B)
CXR in fever of unknown origin. Children may
have pneumonia without clinical signs.
64
Children with asthma usually have normal CXR
Not indicated apart from bronchial wall thickening. Sudden
Wheeze CXR (I) M M M M
routinely (B) unexplained wheeze CXR indicated, may be due
to inhaled FB (above).
Uroradiology
Both examinations may be needed to evaluate
Continuous wetting IVU (II) L L L L Indicated
duplex system with ectopic ureter.
GLOSSARY
Classification of the typical effective doses of ionising radiation from common imaging
TABLE
procedures
* The average annual background dose in most parts of Europe falls in Band II.
65
Chapter V
66
Optimisation Strategies
Any optimisation strategy should be designed with consideration to the
diagnostic requirements of a given clinical situation. The referral guidelines
mentioned in chapter IV are an excellent starting point for developing such
optimisation strategies. The ideal clinical practice strategy should, in the first
instance, lead to a reduction in the number of patients referred for investigation
and, therefore, to a reduction in radiation exposure to patients. Additionally,
the choice of imaging method must be made on the basis of evidence-based
medicine. When developing clinical pathways for digital projection radiography
as a diagnostic tool, the goal is to meet the requirements of the referring
physician – which means choosing an imaging method and adjusting
technique parameters to fit the given clinical task with the lowest risk to both
patient and staff.
After deciding which imaging method to use, the next issue is deciding the
correct image quality. This, again, depends simply on the clinical application;
on the “question” that has to be answered. Evaluating a fracture without
dislocation, for example, requires high image quality, establishing the
position of a fracture requires medium image quality, and locating a metal
object requires a low image quality. Depending on the imaging method, three
dose levels (or speed classes, if referring to conventional films/screens) can
be assigned (e.g. speed class 400, 800, 1600). This represents the
amendment of conventional radiography referral guidelines for use in digital
radiography by adding an additional parameter: the image quality class (low,
medium or high) when using digital radiography.
67
Selection of the Organprogram (e.g. Spine lat)
Selection of the
Exposure parameters
Film/Screen exposures of
20 Patients (Reference point)
Exposures of 3 patients
Optimisation (small, normal, thick)
no yes
Image Quality ok?
“Black box”
Input Output
Image
post-processing
Monitor
Test image
(CDRAD)
This "black box” can be described in terms of the relation between an input
function and an output function. A useful input function would be a digital test
68
pattern, placed like a trojan horse within a digital image. The output function
can then be analysed in a numerical way. A more practical approach would be
to perform an exposure of a test phantom with typical organ parameters in
order to study the image quality on dedicated display monitors or on laser films
via a viewing box. A good example of this phantom is the CRRAD 2.0 phantom
(Artinis Medical Systems B.V.). Several of the squares (see below) contain a
number of cylindrical objects each, each of different diameters and depths.
These have to be detected by human observers. Exposures with different dose
values and scattering material can indicate that the system being used has low
contrast detectability. Using this phantom enables one to study the whole
imaging chain. Phantom measurements cannot optimise the imaging chain,
but can assess the imaging chain for quality control, standardization and
comparison purposes.
The CDRAD Phantom is a good tool for evaluating the imaging characteristics
of digital radiographic systems, including computed radiographic imaging
taken using storage phosphor systems or flat detector systems. One of the
principle concerns in using digital radiography is the potential reduction in
detail, which can have an adverse affect on diagnosis. Resolution (bar
phantom) test objects, which are used to evaluate conventional x-ray imaging
systems, are generally not appropriate for evaluating digital systems. The
CDRAD Phantom allows reliable evaluation of the detail information, with the
main disadvantage being that evaluation is time-consuming and observer-
dependant. Therefore, we developed a program that automatically evaluates
detail information (see annex 2). We first checked the sensitivity (correctly
detected hole patterns) of the evaluation, looked for for alterations caused by
post-processing parameters and the reproducibility of the results.
69
Fig. 4 shows the sensitivity (detected holes) and the standard deviation of 10
exposures in a group depending on the dose (mAs). Detected by the
automatic detection program.
140
77kV / 63mAs
120
77kV / 28mAs
100
80
77kV / 6,3mAs
60
40
20
0
0 1 2 3 4
Fig. 4: Sensitivity(correct detected holes) of CDRAD images depending on the dose.
Standard deviation of 10 exposures in a group.
100
90
80
70
Sesitivity
60
50
40
30
20
10
0
A B C D E F G H I
M u lti-F re q u e n c y B a la n c e C u rv e s
70
To characterise the exposure conditions and the post-processing, a
“thumbprint” of the unit for a special organ program is necessary. Without
automatic post-processing optimisation, different local parts of an organ
exposure can be simulated by CDRAD Phantom exposures, each using
different dose values (fig. 6). Fig. 7 demonstrates examples of thumbprints of
different organ programs. Results from different reference centres are also
useful in developing guidelines by which images and post-processing can be
standardised - but this is a job for a future program.
Dose
Without automatic optimisation by post-processing
Fig. 6: Thumbprint of a unit
71
Image quality thumbprint
Sensitivity
Hand ap. BWS ap.
100 100
90 90
80 80
70 70
60 60
% 50 % 50
40 40
30 30
20 20
10 10
0 0
0 2 4 6 mAs 8 10 12 14 0 10 20 30 mAs 40 50 60 70
Dose value
BWS lat.
Abdomen 100
100
90
90
80
80
70
70
60
60
% 50
% 50
40
40
30
30
20
20
10
10
0
0
0 10 20 30 mAs 40 50 60 70
0 5 10 15 mAs 20 25 30 35 40
Fig. 7: Image quality thumbprint of different organ programs (hand a.p., abdomen,
spine a.p., spine lat)
Quality control
Quality control can be performed by phantom exposures that assess the whole
imaging chain. Qualitative evaluation can be obtained at the level of digital
stored images, monitors or film documentation. This can be achieved by
subjective assessment of image quality displayed on dedicated monitors or
films (for example, spatial resolution or contrast detectability) or by direct
evaluation of the digital images using computer QA programs (for example,
signal/noise).
72
Quality Assurance
Constancy testing
CR CR CR CR
Laserimager
Flat detector
Test images
SMPTE
Testpattern
Digital radiography imaging chains can be divided into two parts: imaging
acquisition and documentation on monitors and laser films. The image quality
of test phantom exposures(DIN 6868-58) can be evaluated by digital
parameters such as signal/noise ratio, dynamic range or homogeneity. These
parameters can be assessed by directly analysing the digital image. Image
documentation testing can be performed through the use of digital test
patterns, such as the SMPTE test. These can be evaluated either on a monitor
or on laser film. The data should be stored and displayed as curves to
demonstrate the results over a given period of time.
73
patients and staff through lowered dose levels. Constancy testing should keep
the image quality constantly high by giving relative measurement values with
reference to the acceptance test at the beginning. Follow ups and trends, for
example, are of great interest to constancy testing.
QA measurements:
Evaluation:
Parameters:
homogeneity
signal/noise
high contrast (lead bar pattern)
low contrast
dynamic range
The exposures has been evaluated by an automatic program (see annex 3).
An example of the results is shown in fig. 9. The quality of monitor and laser
film images has been described by the SMPTE phantom images.
74
Automatic
evaluation of
test images
1.640
• Dynamic range
1.620
Gra uwert
1.600
• Signal/Noise 1.580
• Contrast
1.560
1.540
15 1
0 2. 1
06 1
17 1
23 1
1. 01
01
01
2. 01
02 1
01
09 1
01
01
.01
26 1
01
09 1
01
01
01
01
30 1
01
1 .0
.0
.0
3 .0
3 .0
.0
.0
4 .0
.0
.0
4 .0
0
2.
2.
.03.
3.
3.
3.
3.
.04.
4.
4.
.04.
4.
02
03
03
04
04
04
.02
.0
.0
.0
.0
.0
.0
.0
.0
.0
.0
.0
.0
.0
.0
.0
.0
1 2.
1 6.
2 9.
1 4.
1 9.
• Homogeneity
26
29
04
07
18
05
12
19
22
12
26
Da tum
MA 3 : G r a u w e r t m it t e l/ k le in s t e r / g r ö ß t e r G r a u w e r t
• Resolution
3 5. 0 00
3 0. 0 00
2 5. 0 00
G r auw e rt mit t e l
2 0. 0 00
k el ni s t e r
g r ö ß t e r G r auw er t
1 5. 0 00
1 0. 0 00
5. 0 00
3,5
• Density
MP 0
2,5 MP 1
MP 2
MP 3
op tische Dichte
2 MP 4
• Homogeneity
MP 5
MP 6
1,5
MP 7
MP 8
MP 9
• Contrast
1
M P 10
0,5
0
07 .01
09 .01
26 1
30 1
29 1
04 1
12 1
15 1
18 1
02 1
05 1
12 1
16 1
19 1
22 .0 1
29 1
02 1
06 1
09 1
12 1
14 .01
17 1
19 1
23 1
26 .0 1
03 1
07 1
11 1
1
2 .0
2.0
2.0
3 .0
3.0
3.0
.0
3 .0
3.0
4.0
4 .0
4.0
4.0
.0
4 .0
5 .0
5.0
5.0
1.0
.0
2 .0
.0
.0
4 .0
2
.03
.04
.01
.03
.03
.04
.04
.0
.0
.0
.0
.0
.0
.0
.0
.0
.0
.0
.0
.0
.0
.0
.0
.0
.0
.0
.0
.0
.0
26
Datum
75
Dose watching
10,0
8,0
uGy
6,0
4,0
2,0
0,0
Exposure
2 500
2 000
EI
1500
1000
500
Exposure
Fig. 11: Monitoring dose values for an organ programme (“dose watching”)
76
Chapter VI
Abstract :
Results: The evaluation of CDRAD images demonstrated that the flat detector
system delivered the highest contrast detectability, followed by the FCRXG1,
the ADC-Solo, and the ADC70 systems. Comparison of organ-phantom
images showed that the flat detector system in particular demonstrated
excellent image quality at low speed classes in comparison to film/screen and
storage phosphor systems.
77
Introduction
In recent years, the range of digital image information available to radiologists
has been growing rapidly. This has been fuelled to a large extent by the
improvements to workflow brought by fast image transfer, safe storage and
images being much more easily accessible in digital form. Despite the
dramatic progress in the fields of CT and MRI, projection radiography of the
lung, skeletal and gastrointestinal tracts still form the largest areas of routine
clinical radiology use. The development of storage phosphor plates and
introduction of flat detectors has, however, significantly enlarged and improved
the spectrum of digital methods for projection radiography (1). The milestones
of reached by these new imaging methods include the significant increase of
image quality and the new potential for dose reduction (2, 3, 4).
Over a several years, there have been a number of national and international
efforts to increase the diagnostic value and to minimise side effects of imaging
with x-rays (Council directive 97/45 Euratom). The ALARA principle (dose As
Low As Resonably Achievable) means that imaging has to be done with
sufficient image quality, yet a low-as-possible dose value. This prerequires
optimised technical equipment and sufficient knowledge of its imaging
capabilities for certain dose values. This publication evaluates the relation
between image quality and dose for different generations of storage phosphor
and flat detector units in comparison to film/screen units. The results can serve
as a basis on which to develop new strategies for optimal use of these
methods (5).
78
Images of 4 phantoms were evaluated:
The hand, abdomen and thorax phantoms consist of organ parts embedded in
perspex.
79
Exposure conditions
Storage phosphor plates and film/screens were exposed at a Bucky table
(Philips: Bucky Diagnost), flat detector images at a dedicated unit (Philips:
DigitalDiagnost).
The process started with a film/screen image at speed class 400. Orientated to
this fixed mAs value for the speed class 400 of film/screen, exposures of the
other phantoms were taken for speed classes 200, 400, 800, 1600. For thorax
exposures, the dose values were limited to speed 200, 400 and 800 because
of the limitation of switch time of the generator. Sequences of exposures had
been taken with the described phantoms for 50 kV, 73 kV and 109 kV.
Standard post-processing was run for 50 kV using the parameters of the hand
program, for 73 kV using the organ program “abdomen”, and for 109 kV with
the organ program “thorax”. Exposures of the CDRAD phantom with 50 kV
(hand parameters) had 3 cm of perspex as additional scatter material;
exposures with 73 kV (abdomen parameters) had 14 cm perspex, and
exposures with 109 kV (thorax parameters) had 10 cm perspex. Holes of small
diameter should be imaged in a direction nearly parallel to the central beam by
asymmetric (decentralised) positioning (19). The grey values of the
documentation on laser image films were normalised to a reference density of
1.2 +/- 0.2.
The shape of the diagrams were difficult to compare. Therefore, the areas
under the curves (sum of drill depths) were evaluated. To take in account the
different parts of the curve, the results were shown for two ranges of diameters
(diameter 0.5 – 2.0 and diameter 2.5 – 8 mm). The lower the sum of the drill
80
depths is, the more the contrast detectability of the different imaging methods
improves.
Fig. 2a: Hand phantom with Fig. 2b: Abdomen phantom with
windowing for evaluation windowing for evaluation
Results:
Fig. 3 shows a boxplot diagram of the relative detectability for 50 kV with
speed classes 200, 400, 800 and 1600. Lines above and below show the
maximum and minimum values. The line within the box demonstrates the
median and divides it into a second and third quartile. The straight line gives
the value of film/screen images with speed class 400.
70 60
% %
60 50
50 40
40 30
Fig. 3a: Dose class 200(8mAs) Fig. 3b: Dose class 400(4mAs)
50 %%
42 DiDi
% %
DiDi
40
DiDi
38
40 36
34
32
30 30
28
26
20 24
Fig. 3c: Dose class 800 (2mAs) Fig. 3d: Dose class 1600 (1mAs)
82
Fig. 3: Boxplot diagram of relative detectability
(400 speed class of film/screen (50%))
DiDi: DigitalDiagnost - Philips (flat detector)
FCR XG1: FUJI (storage phosphor)
Solo: AGFA (storage phosphor)
ADC-70: AGFA (storage phosphor)
The following figures show the mean values of the CDRAD evaluation for 50
kV (Fig. 4), 73 kV (Fig. 5) and 109 kV (Fig. 6).
70
60
Digital Diagnost
relative Detectability (%)
50
FCR XG 1
40 ADC-Solo
30 ADC-70
Film/Folien
20
10
0
8mAs 4mAs 2mAs 1mAs
(200) (400) (800) (1600)
mAs
(speed classes)
83
60
50
relativedetectability (%)
40
Digital Diagnost
FCR XG 1
30
ADC-Solo
ADC-70
20
Film/Folie
10
0
16mAs (200) 8mAs (400) 4mAs (800) 2mAs (1600)
mAs (speed classes)
Fig. 5: CDRAD evaluation 73kV- relative detectability
60
50
relative detectability (%)
40
Digital Diagnost
FCR XG 1
30
ADC-70
20 F/F
10
0
2mAs (200) 1mAs (400) 0,5mAs (800)
mAs (speed classes)
The contrast detectability shows the depth up to which the drill pattern with
fixed diameters was detected correctly. The following diagrams show the
mean value of the results noted by all observers for the sum of depth values.
Fig. 7a shows the results for drill depth of 0.5-2.0 mm, figure 7b for drill depth
2.5 -8mm.
84
Sum of depth(mm)
35
30
25 Digital Diagnost:
FCR XG 1
20
Film/Folie
15
ADC-70
10
ADC- Solo
5
0
8mAs 4mAs 2mAs 1mAs
(200) (400) (800) (1600)
mAs
Dose (Speed Class)
10
9
Sum of depth (mm)
8
7 Digital Diagnost
6 FCR XG 1
5 Film/Folie
4 ADC-70
3
ADC- Solo
2
1
0
8mAs 4mAs 2mAs 1mAs
(200) (400) (800) (1600)
mAs
Dose(Speed Class)
85
Hand, abdomen and thorax phantom exposures
The following tables show the results of the evaluation of hand, abdomen and
thorax exposures (Table 1, 2, 3).
ADC-Solo 200
ADC-70 200
Film/Slide 400
86
Image quality Unit
High Digital Diagnost 200 400 800
Film/Slide 400
Film/Slide 400
87
Discussion:
The goal of this study is to optimise digital imaging by assessing the imaging
capabilities of different methods and systems, depending on the dose level.
Therefore, a comparison between different digital systems and a film/screen
system was performed. Exposures were taken using four different phantoms
(CDRAD phantom, hand phantom, abdomen phantom and thorax phantom).
The relative detectability of the specific systems in relation to dose shows that
flat detectors with speed class 800 demonstrate the same detectability as the
storage phosphor system ADC 70 with speed class 200. This result means
that, at the same image quality, the flat detector system allows a dose
reduction of 75%. It should be noted, however, that the ADC-70 system is six
years old and therefore no longer the latest generation of storage phosphor
systems. The results of state of the art systems shows that development of
technology over this period has led to a significant increase in image quality.
In terms of contrast detectability of the exposure series 50 kV, the first part
of the curve (diameter 0.6-2.0mm) demonstrates the superiority of the flat
detector for all speed classes. The storage phosphor systems FCRXG1, ADC-
Solo and ADC-70 show a lower quality. The second part of the curve (diameter
2.5 – 8.0) demonstrates the the same sort of superiority of the flat detector
with the exception of the 400 speed value.
For CDRAD exposures with 73kV and 109 kV, the flat detector system is at the
top of the row for all speed classes, followed by the storage phosphor systems
FCRXG1, ADC-Solo and ADC-70.
Neitzel (6), Geijer (7) and Peer (9) used the same CDRAD phantom for their
studies of imaging capabilities of different digital imaging systems. Our results
prove the statements of these publications – that flat detector systems
demonstrates a higher image quality in comparison to film/screen systems with
a significant lower dose value. This study additionally shows that the image
88
quality of storage phosphor systems is dependent on the age (generation) of
the system. The ADC-70, the oldest system, had the worst results. The
FCRXG1, as a representative of the new generation systems, is even
equivalent to the flat detector in some cases. A comparison of flat detector
system and film/screen showed that a similar quality had been reached with
significantly lower dose.
Exposures of the hand were taken at the voltage of 50 kV. Observers graded
the total quality of flat detector images highest, followed by FCRXG1, ADC-
Solo and ADC 70. DigitalDiagnost, FCRXG1 and ADC solo were graded as
producing “high” image quality. DigitalDiagnost and FCRXG1 provided the
highest dose reduction (up to 75%). Film/screen images were graded as
“medium”. The ADC 70 needed double the dose to produce similar image
quality. DigitalDiagnost and FCRXG1 required only 25% of the dose compared
to film/screen. This potential for dose reduction has also been described by
other authors mentioned in the references (2, 3, 4, 10, 11, 12).
For exposures of the abdomen with a voltage of 73 kV the flat detector (speed
class 200, 400, and 800) had been graded to the quality class “high”.
Film/screen images with speed 400 were in the “medium” class. The flat
detector image with speed 1600 was also graded to this class. In this case, a
dose reduction of 75% was possible – without loss of quality. But in
comparison to film/screen, there is storage phosphor systems at speed 200
are of no improvement. Doubling the dose also gives no additional image
information. In the quality class “low”, storage phosphor images (FCRXG1,
ADC-Solo, ADC-70) with speed classes 800 and 1600 were allocated. Overall,
the results of the abdomen exposures demonstrated the high potential for
dose reduction for the flat detector. This would also confirm what has been
stated by various publications (11, 13).
For the comparison of lung exposures; the DigitalDiagnost, the FCRXG1, the
ADC 70 and the film/screen system were available. The results show that flat
detector images were graded similar to FCRXG1 images. Imaging methods in
both the quality classes “high” and “medium” had the same speed class. The
ADC 70 images were graded lower in all speed classes. These advantageous
imaging capabilities of digital systems for the thorax had been described
already by some authors (14, 15, 16, 17, 18, 19).
The results show that there is a significant gap in image quality between the
flat detector system, the storage phosphor system, and the film/screen system.
89
The flat detector demonstrated the highest potential for dose reduction for
each of the evaluated phantom images. It was also shown that the gap in
image quality between state of the art storage phosphor systems and flat
detector systems has narrowed. The ADC 70, the oldest unit, produced the
lowest quality.
90
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gittergesteuerter gepulster Durchleuchtung”, Akt.Radiol. 8: 191-195
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2000
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Panel X-ray Detector : Contrast-Detail Evaluation with Processed Images
Printed on Film Hard Copy”, Radiology 201; 218: 679-682
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with a Solid-state Flat-Panel X-ray Detector: Contrast-Detail Evaluation with
Processed Images Printed on Film Hard Copy”, Radiology 2001; 218: 679-682
Hennis, S.P., Garmer, M., Jaeger, H.J., Classen, R., Jacobs, A., Gissler,
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Jaschke, W. “Comparison of low-contrast detail perception on storage
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Radiat Prot Dosimetry, 94 (201) 1-2, 69-71
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101
102
Annex1:
DIMOND III
(Contract: FIGM-CT-2000-00061)
Final Report
1st October 2003
Lead contractor:
Workpackage 1
Clinical Quality Criteria
Leading partner:
WP 1.2: Identification of the three image quality bands
WP 1.4: Report on clinical quality criteria for new digital
technology
WP 2.2: QA protocol for digital detectors and new imaging
devices
WP 6.7: Circulation of mammography images between
centres
103
DIMOND III
104
Workpackage 1: Clinical Quality Criteria
105
WP 1.8. Pilot study on equipment requirements for
fluoroscopic guided interventional radiology
Lead partner: H. Zoetelief, Delft
106
DIMOND III
WP 1.2:
Identification of three image quality bands
One of the main focuses of WP 1.2 was last year’s development of a computer
program to automatically evaluate CDRAD images by pattern recognition. This
was a breakthrough because of the significant decrease in workload it has
brought and the objectivity it gives to CDRAD image evaluation. We tested the
program intensively and determined its sensitivity and performance. This
program is now available to all DIMOND III partners.
Starting with the “Referral guidelines for imaging” (Radiation Protection 118),
we asked DIMOND partners to define the necessary image quality for all
diagnostic questions. We received responses from four centres.
We then modified our proposal based on these results and distributed them to
all DIMOND partners prior to the Trier meeting in October 2002. As a result of
the discussion that took place at this meeting, we cancelled the trial that had
been planned for February 2003. These results have now been outlined. This
should be the starting point of a broad discussion within the European
community of radiology and radiation protection.
107
2. Definition of three image quality bands for digital radiography
Based on the results of phantom measurements taken with the CDRAD
phantom, we defined the three bands for different storage phosphor systems
and a flat detector system. The results were presented as part of a refresher
course at the German Röntgenkongress (radiography conference) 2003.
These results were then discussed extensively during the DIMOND meeting in
Trier with specific reference to digital images. A full set of clinical images of the
image quality band is now available to all DIMOND partners for the purpose of
training and education.
Summary:
WP 1.2 achieved what it set out to do at the beginning. We convinced our
partners to take the CDRAD 2.0 as a standard phantom for evaluating image
quality in the project and intensively discussed the results of criteria for the
three image quality bands and their application to clinical problems.
108
List of deliverables
Partners:
Haughton Institute, Ireland (Prof. Dr. Jim Malone)
Department of Radiology, Leuven (Dr. Hilde Bosmans)
Department of Radiology, Innsbruck (Prof. Dr. W. Jaschke)
Medical Physics Department, Newcastle(Dr. CJ Kotre)
Department of Radiology, Karlsruhe (Dr. S. Vetter)
Linked projects:
1.4 Lead partner: BKT Trier
1.6 Lead partner: Radiology Innsbruck
1.10 Lead partner: Radiology Innsbruck
4.1 Lead partner: Radiology Karlsruhe
5.1 Lead partner: Azienda Ospedaliera Udine
6.1 Lead partner: Radiology Innsbruck
109
WP 1.4:
Report on clinical quality criteria for new digital technology
The main goal of this workpackage was to adapt quality criteria to further
digital imaging procedures involved in the DIMOND II project. The
recommended diagnostic requirements for digital projection radiography are
based on the European Guidelines on Quality Criteria for Diagnostic images
(EC), the diagnostic requirements for digital radiographic procedures
(DIMOND II) and the guidelines published by the Bundesärztekammer
(German Federal Medical Association) for quality assurance in radiological
examinations. We sent these recommendations to all partners for further
examination. Additionally, we asked the partners to send us technical
parameters of their exposures. Using this material, we prepared a contribution
to a book on European guidelines on quality criteria for diagnostic digital
radiographic images, similar to what already existed for conventional
film/screen radiography.
110
2. Trial (WP 1.4 partners)
Summary:
WP 1.4 is now finished. After intensive discussion with the DIMOND partners,
we are now preparing the draft for the final meeting. A full set of clinical
examples is now available for all DIMOND partners.
List of deliverables:
1. Adapt quality criteria for new digital technology (Yes)
2. Trial at Trier meeting (partners of DIMOND III) (Yes)
3. Final workshop with clinical partners (at Trier meeting) (Yes)
4. Contribution to the draft version of “European Guidelines on Quality
Criteria for Digital Projection Radiography” (Yes)
111
WP 2.2:
QA protocol for digital detectors and new imaging devices
2. Trial (partners)
112
Summary:
WP 2.2 is now finished. Over the course of the workpackage, we developed a
new procedure for constancy testing based on the new capabilities of digital
imaging. We then tested this procedure over a long period and discussed the
results intensively with our colleagues and DIMOND partners. In addition, we
developed a new computer program to automatically evaluate the test images.
This program is now available to all DIMOND partners via the internet.
Deliverables:
1. Develop a QA protocol for digital detectors and new image devices (Yes).
2. Discussion/feedback from the partners (Yes)
3. Meet to discuss and summarise results (Trier meeting) (Yes)
4. Contribution to the draft of European guidelines (Yes)
Partners:
Haughton Institute, Dublin( Prof. Jim Malone)
Department of Radiology, Madrid ( Prof. E. Vano)
Department of Radiology, Leuven (Dr. H. Bosmans)
Department of Radiology, Innsbruck (Prof. W. Jaschke)
Department of Radiology, Karlsruhe (Dr. S. Vetter)
Linked projects:
1.2. Lead partner: BKT Trier
1.5. Lead partner: Newcastle City Health Trust
1.6. Lead partner: Radiology Innsbruck
1.10. Lead partner: Radiology Innsbruck
4.1. Lead partner: Radiology Karlsruhe
6.1. Lead Partner: Radiology Innsbruck
113
WP 6.7:
Circulation of mammographic images between centres
1. Preparation
Circulation of mammography images will coincide with the final report in 2004.
This set of images contains both clinical and test images and was put together
from images received from our DIMOND partners in Innsbruck and Madrid.
Summary:
WP 6.7 was not totally successful. If we can obtain more images over the next
few months, we will integrate them into the image file for the final workshop.
114
Annex 2:
JAnalyser-CDRAD
Quality Testing of Digital Projection Radiography
C. SCHILZ
115
“Contrast-Detail CDRAD phantom”
(Designer’s description: Nuclear Associates / USA)
Introduction
Most definitions of image quality in radiology are based on characterizing the
physical properties of the image chain. However, medical diagnosis is not
made on the basis of the image alone. The observer’s perception of the image
is crucial to the result. This perception can be tested using so-called Contrast-
Detail (CD) phantoms. These CD phantoms make it possible to quantify both
detail and contrast, as observed by the radiologist. The CDRAD phantom can
be used within the entire range of diagnostic imaging systems, such as
fluoroscopy and digital subtraction angiography.
Construction
The CDRAD phantom consists of a Plexiglas tablet with cylindrical holes of
exact diameter and depth (tolerances: 0.02 mm). Together with additional
Plexiglas tablets, which are used to simulate the dimensions of the patient, the
radiographic image of the phantom gives information about the imaging
performance of the whole system.
Evaluation
To evaluate the phantom image, the observer indicates the location of the
second spot in each square. Correct indication proves that a the observer
really does see contrasts. At the transition from visible to invisible, it is difficult
116
to decide in which corner the second spot is located, and the response equals
pure chance. The line connecting the central spots with smallest visible
diameter and contrast is called the contrast-detail (CD) curve. In order to
compare the imaging performance of different systems, phantom images are
made under identical conditions and evaluated by the same observer and at
the same time. The better system will produce an image in which smaller
contrasts and details are visible. This results in a shift of the CD curve to the
lower left part of the image
There are some good reasons for evaluating the examination by computer.
Manual evaluation:
Computer-based evaluation:
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How does the program work?
The 15x15 grid of spot-containing squares is surrounded by a thin metallic
grid, which is easily visible during the examination. Using various methods of
digital image processing (edge enhancement, skeletation, outline pursuit the
grid is selected and the adjustment of the phantom is determined. If the grid is
completely shown, any turn of the phantom can be recognized (although due
to the divergence of the x-rays, dertermining the position of the grid is not
simple).
The result is compared with the CDRAD phantom. If the position of the spots is
determined correctly, then the square is considered as recognized (“1”). If the
position is not correctly determined, then the square is considered as not
recognized (“0”). The results for all 225 fields are then submitted for a
plausibility check, because the evaluation is prone to error.
The plausibility check minimizes the influence of:
Fields that are correctly recognised by chance
Fields that are not recognized fields (but should have been)
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Procedures for evaluating the position of the spots
Hough transformation
A filter is applied to extract the outline of the spots (edge extraction) from the
original picture. Hough transformation is then applied to these outlines,
dependent on the diameters of the spots. This hough transformation transmits
the outer edge of the circle to the centre of the circle. The positions of the
centres are determined by a search for the two maximum values .
- If one of the two maximum values is in the centre and the other in a corner
of the square, the square is provisionally recognized. Tests are then carried
out to establish whether the spot is in the correct corner. If it is, then the
square is considered as recognized.
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Annex 3:
JAnalyser
Constancy Testing of Digital Projection Radiography
C. SCHILZ
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General information
Constancy test evaluation is computer based, with high contrast, low contrast,
homogeneity, the square wave response function of the lead bar pattern and
the light field/xray-field are all measured.
image (A to D)
After these marks have been found, the program calculates
the characteristic values for high contrast, low contrast,
homogeneity, the square Wave Response Function” of the
lead bar pattern and the light field/xrayfield. C D
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Constancy Testing for digital x-ray units
1. Linearity
The input signal changes by the factor α, then the output signal
changes with the same factor α. The intensity value from the sum of
the single intensities is devoted to two objects which are
superpositioned in the object level (absolute detected values, without
calibration or adjustment by exposure index)
Logarithmically linearity
The input signal changes by a factor α, then the output signal
changes with the factor “log α”
3. Time invariance
Images made under comparable conditions but at different times
should be identical.
X-ray systems fulfil only the first two of these criteria, while constancy tests are
based on time invariance.
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The first criteria is restricted through
- A partial lack of logarithmic linear/linear characteristics
- Change of measured values by post-processing (which is not
influenced by the user)
These first two demands are system-dependent and cannot not be ignored.
For constancy tests, the restriction is not importanted if
Constancy tests for digital systems can be execuded under the same system
characteristics as as conventional (film/screen) constancy tests.
Measurements of these characteristics must be adapted to the requirements
and conditions of digital radiography.
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This phantom allows all relevant data to be assessed:
- Dynamic range,
- Detail detectability,
- Spatial resolution
- Homogeneity
- Light field / x-ray field
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Dynamic range
In conventional radiography, optical density depends on dose. The dynamic
range of an examination depends on the dose and the film-screen combination
selected (as well as whether a film is over-exposed, correctly-exposed, or
under-exposed). The constancy of an analogue x-ray device can be
established if constant dose values produce the same optical density. The
relationship between dose and optical density is logarithmically linear.
For digital x-ray devices, dynamic range can be adapted using post-processing
techniques. Images will show the same brightness independent of the dose
(see fig. 3). There is no relation between printed grey value / optical density
and dose.
Nearly all digital x-ray systems have a logarithmically linear relation between
dose and detected value. For constancy tests of digital x-ray systems, a
measured value should be used, which is unchanged or linearly changed
during post-processing. The high contrast is measured in the seven fields
shown above, with the different mean values describing the dynamic range. In
logarithmic linear systems, the noise is defined by the standard deviation. If
post-processing is linear, the standard deviation within homogeneous ranges
is linearly dependent on the dose and the gradient of the post-processing
curve. The post-processing parameters must be kept constant for the
constancy test so the standard deviation depends only on the dose.
The "average value" (signal) and the "standard deviation" (noise) are
calculated (automatically) for different levels of the grey values. If the quality of
the x-ray system changes, the measured “average values” and “standard
deviation” change too.
For the interpretation of the change further measured variables are necessary
(e.g. the area dose product or surface dose)
Detail detectability
Objects can be detected in relation to the contrast of the surrounding area.
However, the next four pictures show that contrast is not the only criterion for
detectability.
The four images have the same tube voltage (81 kV) but different dose
classes (S200, S400, S800, S1600). All images have the same contrast.
You can see that, in addition to the contrast, noise is also important to the
detectability of objects. The higher the noise gets, the more difficult it is to
recognize the objects.
In the low contrast area, the "contrast" and the relationship between the
object's contrast and noise of the objects can be determined (automatically). If
the quality of an x-ray system (and thus the detail detectability) decreases,
then the contrast/noise ratio decreases too.
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What JAnalyser does
Meanup − Meandown
Contrast ( HC x ) = MeanObj −
2
Meanup − Meandown
MeanObj HC x −
Contrast ( HC x ) 2
=
N ϑObj HC
x
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Homogeneity
The demand “local or shift invariance” on x-ray systems is restricted by:
The influence of these effect should be able to be kept as small as possible by:
Horizontal homogeneity:
For noise reduction, vertical grey values are averaged.
After that, the minimum (gmin) and maximum (gmax) grey
value is determined and the homogeneity can be
calculated.
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Spatial resolution / square wave response function
If a sinusoidal distribution of intensity in the object level is represented by an
imaging system, then the distribution of intensity of the image has the same
spatial frequency as that of the object.
Mod (u )
MTF (u ) =
Mod (0 Lp / mm)
The production of a sinus wave raster is very complex and expensive. For this
reason, constancy tests are made using a lead bar pattern. With lead bar
patterns, the square wave response function (SWRF) is measurable. This
function stands in close relationship to the MTF.
In order to state the constancy, the SWRF measurement and the relative
comparison to the accepting test are sufficient.
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For an exact determination of the MTF/SWRF, single images of lead bar
pattern are insufficient. Particularly at high spatial frequency, the number of
based measuring points becomes too small.
The SWRF measurement is more precise than the determination of the last
visible linepair in analogue radiography. In the SWRF, the last visible linepair
corresponds with the range, in which the curve leads to zero.
Fig. 11: Lead-bar pattern After that, the program calculates the mean
value for each row and searches the three
maxima and two minima (or two maxima and
three minima).
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Fig. 12: mean values of the rows
The linepair is recognized and the program finds exactly three maxima (max1
until max3) and two minima (min1 until min2). If this is impossible, the
SWRF(lp(n)) is set to 0. (= > line pair cannot be recognized).
The modulation and the SWRF are calculated using the following formula.
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Light field / X-ray field
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Annex 4:
CD1: Quality and Dose Management for Digital Radiography
133
CD Einlegeblatt 1
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CD Einlegeblatt 2
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Annex 5:
Acknowledgements
Those involved in the DIMOND projects (DIMOND I, II, and III) can look back
on 13 successful years of cooperation. This European study has made a
significant contribution to the development of digital radiography as a new
examination technique. Our goal was to achieve optimal image quality (and
with it, better diagnostic information) under minimal radiation doses and to
standardize digital radiography techniques all over Europe.
Now that DIMOND III has come to and end, I would like to express my thanks
to all of the European research groups involved for both the collaboration and
the interesting dialogue that came out of it. In particular, I would like to thank
the projects' founding members, Dr. Keith Faulkner and Prof. Dr. Jim Malone,
who directed and coordinated the projects DIMOND I-III with dedication and
enthusiasm. Our collaboration over the last 13 years has turned into great
friendship – a wonderful example of how Europeans can grow closer on a
scientific and a social level. Besides the scientific research, DIMOND will
surely be remembered by all by their experiences at the various events that
took place over the course of the project.
The DIMOND project would not have been possible without the support of the
European Union, and I would also like to take this opportunity to thank them
for their support and patronage, particularly Dr. Schibilla for her extraordinary
efforts in the early years.
Thanks are also due to the Krankenhaus der Bamherzigen Brüder hospital in
Trier for their support during the project – in particular for their understanding
of the numerous compromises and allowances made for DIMOND.
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Special thanks go to the DIMOND team at the radiology department at the
Krankenhaus der Barmherzigen Brüder hospital here in Trier for their work and
dedication:
Christian Decker
Clemens Schilz
Anke Jockenhöfer
Stephanie Busch
Marion Anschütz
as well as the rest of the staff at the radiology department, whose extra
workload has now paid off.
Lastly, I would like to thank my wife Hildegard and my children Stephanie and
Thomas for their support and understanding throughout DIMOND, not least for
the large amount of travel I have done over the course of the projects.
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