myostatin (Q29630)

http://www.ebi.ac.uk/interpro/protein/O14793

growth/differentiation factor 8

1 reference

http://www.ebi.ac.uk/interpro/protein/O14793

Transforming growth factor-beta, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

TGF-beta, propeptide family

1 reference

based on heuristic

inferred from protein domain or family

Transforming growth factor beta, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

3 references

8 April 2019

Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease inhibitor and follistatin domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

8 April 2019

Latent myostatin has significant activity and this activity is controlled more efficiently by WFIKKN1 than by WFIKKN2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

8 April 2019

K153R polymorphism in myostatin gene increases the rate of promyostatin activation by furin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

transforming growth factor beta receptor binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

growth factor activity

Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

8 April 2019

signaling receptor binding

Myostatin Signals through a Transforming Growth Factor β-Like Signaling Pathway To Block Adipogenesis

4 references

8 April 2019

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

8 April 2019

Myostatin Signals through a Transforming Growth Factor β-Like Signaling Pathway To Block Adipogenesis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

protein homodimerization activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

identical protein binding

Structure of the human myostatin precursor and determinants of growth factor latency.

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

8 April 2019

Latent myostatin has significant activity and this activity is controlled more efficiently by WFIKKN1 than by WFIKKN2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

8 April 2019

Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

cell component

cytoplasm

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

extracellular region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

1 reference

8 April 2019

extracellular space

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

4 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

8 April 2019

Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease inhibitor and follistatin domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

regulation of apoptotic process

biological process

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

negative regulation of protein kinase B signaling

1 reference

8 April 2019

Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

negative regulation of myoblast differentiation

1 reference

8 April 2019

Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

regulation of MAPK cascade

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

SMAD protein signal transduction

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

muscle cell cellular homeostasis

1 reference

8 April 2019

Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

cell development

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

response to testosterone

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

positive regulation of pathway-restricted SMAD protein phosphorylation

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

muscle organ development

TAS

1 reference

8 April 2019

Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

response to glucocorticoid

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

response to heat

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

response to electrical stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

negative regulation of myoblast proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

1 reference

8 April 2019

ISS

ovulation cycle process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

cellular response to dexamethasone stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

negative regulation of muscle hypertrophy

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

response to estrogen

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

negative regulation of skeletal muscle satellite cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

1 reference

8 April 2019

positive regulation of transcription, DNA-templated

ISS

1 reference

8 April 2019

Myostatin Signals through a Transforming Growth Factor β-Like Signaling Pathway To Block Adipogenesis

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

response to gravity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

negative regulation of insulin receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

skeletal muscle tissue regeneration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

skeletal muscle atrophy

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

negative regulation of satellite cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

1 reference

8 April 2019

ISS

response to ethanol

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

negative regulation of skeletal muscle tissue growth

Myostatin mutation associated with gross muscle hypertrophy in a child

2 references

8 April 2019

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

transforming growth factor beta receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

response to muscle activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

negative regulation of kinase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

regulation of signaling receptor activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14793

physically interacts with

Landogrozumab

object of statement has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3545072

Domagrozumab

object of statement has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3544991

exact match

http://purl.uniprot.org/uniprot/O14793

1 reference

Transforming growth factor beta, conserved site

Identifiers.org

has part(s)

1 reference

http://www.ebi.ac.uk/interpro/protein/O14793

Transforming growth factor-beta, C-terminal

1 reference

http://www.ebi.ac.uk/interpro/protein/O14793

TGF-beta, propeptide

1 reference

http://www.ebi.ac.uk/interpro/protein/O14793

Commons category

Myostatin

0 references

Identifiers

1 reference

30 May 2020

1 reference

13 November 2019

0 references

1 reference

1 reference

28 October 2013

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

9 November 2015

http://www.uniprot.org/uniprot/O08689.txt?version=117

1 reference

9 November 2015

http://www.uniprot.org/uniprot/O08689.txt?version=117

1 reference

1 reference

YSO-Wikidata mapping project