Alternative ribosome-rescue factor B (ArfB, YaeJ) also known as peptidyl-tRNA hydrolase,[1] is a protein that plays a role in rescuing of stalled ribosomes.[1] It works like a GGQ-release factor itself, releasing the peptide from tRNA.[2] At the same time, it fits into the mRNA tunnel to remove the mRNA.[3]
| Peptidyl-tRNA hydrolase ArfB | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | ArfB | ||||||
| UniProt | P40711 | ||||||
| |||||||
This gene is also found in eukaryotic organelles as MRPL58 (ICT1). The similarity is high enough to be interchangeable.[4] Its role has expanded to that of a codon-independent release factor, although it likely still functions in ribosomal rescue.[5]
See also
editReferences
edit- ^ a b "Peptidyl-tRNA hydrolase, ribosome rescue factor". BioCyc. SRI International.
- ^ Chan KH, Petrychenko V, Mueller C, Maracci C, Holtkamp W, Wilson DN, et al. (August 2020). "Mechanism of ribosome rescue by alternative ribosome-rescue factor B". Nature Communications. 11 (1): 4106. Bibcode:2020NatCo..11.4106C. doi:10.1038/s41467-020-17853-7. PMC 7427801. PMID 32796827.
- ^ Carbone CE, Demo G, Madireddy R, Svidritskiy E, Korostelev AA (November 2020). "ArfB can displace mRNA to rescue stalled ribosomes". Nature Communications. 11 (1): 5552. Bibcode:2020NatCo..11.5552C. doi:10.1038/s41467-020-19370-z. PMC 7641280. PMID 33144582.
- ^ Feaga HA, Quickel MD, Hankey-Giblin PA, Keiler KC (March 2016). "Human Cells Require Non-stop Ribosome Rescue Activity in Mitochondria". PLOS Genetics. 12 (3): e1005964. doi:10.1371/journal.pgen.1005964. PMC 4814080. PMID 27029019.
- ^ Richter R, Rorbach J, Pajak A, Smith PM, Wessels HJ, Huynen MA, et al. (March 2010). "A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome". The EMBO Journal. 29 (6): 1116–1125. doi:10.1038/emboj.2010.14. PMC 2845271. PMID 20186120.