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README.md

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 #### Macrophage Annotation of Gene Network Enrichment Tool
 
 #### Available at https://magnet-winterlab.herokuapp.com
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+Characterization of gene lists obtained from high-throughput genomic experiments is an essential task
+to uncover the underlying biological insights. A common strategy is to perform enrichment analyses
+that utilize standardized biological annotations, such as GO and KEGG pathways, which attempt to
+encompass all domains of biology. However, this approach provides generalized, static results that
+may fail to capture subtleties associated with research questions within a specific domain. Thus, there
+is a need for an application that can provide precise, relevant results by leveraging the latest research.
+We have therefore developed an interactive web application, Macrophage Annotation of Gene Network
+Enrichment Tool or MAGNET, for performing enrichment analyses on gene sets that are specifically
+relevant to macrophages. Using the hypergeometric distribution, MAGNET assesses the significance
+of overlapping genes with annotations from recent macrophage studies, that were curated from
+published manuscripts and data repositories. We implemented numerous features that enhance utility
+and user-friendliness, such as the simultaneous testing of multiple gene sets, different visualization
+options, option to upload custom datasets, and downloadable outputs. Here, we use two example
+studies compared against our current database of seven publications on mouse macrophages to
+demonstrate that MAGNET provides relevant and unique results that complement well with
+conventional enrichment analysis tools. Although specific to macrophage datasets, we envision
+MAGNET will catalyze developments of similar applications in other domains of interest.
+
+![image](https://user-images.githubusercontent.com/20377476/164351179-a7b7eeab-716b-44f3-8ed4-8394e4dbef05.png)