TRIO (gen)
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| Faktor razmene trio ro guanina | |||||||||||
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 PDB prikaz baziran na 1nty. | |||||||||||
| Dostupne strukture | |||||||||||
| 1NTY, 2NZ8 | |||||||||||
| Identifikatori | |||||||||||
| Simboli | TRIO; ARHGEF23; tgat | ||||||||||
| Vanjski ID | OMIM: 601893 MGI: 1927230 HomoloGene: 20847 GeneCards: TRIO Gene | ||||||||||
| EC broj | 2.7.11.1 | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 7204 | 223435 | |||||||||
| Ensembl | ENSG00000038382 | ENSMUSG00000022263 | |||||||||
| UniProt | O75962 | Q0KL02 | |||||||||
| RefSeq (mRNA) | NM_007118.2 | NM_001081302.1 | |||||||||
| RefSeq (protein) | NP_009049.2 | NP_001074771.1 | |||||||||
| Lokacija (UCSC) | Chr 5: 14.14 - 14.53 Mb | Chr 15: 27.73 - 28.03 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Protein trofunkcionog domena (engl. Triple functional domain protein) je protein koji je kod ljudi kodiran TRIO genom.[1][2]
TRIO (gen) formira interakcije sa filaminom[3] i RHOA.[4]
- ↑ Debant A, Serra-Pages C, Seipel K, O'Brien S, Tang M, Park SH, Streuli M (July 1996). „The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains”. Proc Natl Acad Sci U S A 93 (11): 5466–71. DOI:10.1073/pnas.93.11.5466. PMC 39269. PMID 8643598.
- ↑ „Entrez Gene: TRIO triple functional domain (PTPRF interacting)”.
- ↑ Bellanger, J M; Astier C, Sardet C, Ohta Y, Stossel T P, Debant A (December 2000). „The Rac1- and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin”. Nat. Cell Biol. (ENGLAND) 2 (12): 888–92. DOI:10.1038/35046533. ISSN 1465-7392. PMID 11146652.
- ↑ Medley, Q G; Serra-Pagès C, Iannotti E, Seipel K, Tang M, O'Brien S P, Streuli M (November 2000). „The trio guanine nucleotide exchange factor is a RhoA target. Binding of RhoA to the trio immunoglobulin-like domain”. J. Biol. Chem. (UNITED STATES) 275 (46): 36116–23. DOI:10.1074/jbc.M003775200. ISSN 0021-9258. PMID 10948190.
- Taviaux S, Diriong S, Bellanger JM i dr.. (1997). „Assignment of TRIO, the Trio gene (PTPRF interacting) to human chromosome bands 5p 15.1-->p 14 by in situ hybridization”. Cytogenet. Cell Genet. 76 (1–2): 107–8. DOI:10.1159/000134524. PMID 9154137.
- Liu X, Wang H, Eberstadt M i dr.. (1998). „NMR structure and mutagenesis of the N-terminal Dbl homology domain of the nucleotide exchange factor Trio”. Cell 95 (2): 269–77. DOI:10.1016/S0092-8674(00)81757-2. PMID 9790533.
- Seipel K, Medley QG, Kedersha NL i dr.. (1999). „Trio amino-terminal guanine nucleotide exchange factor domain expression promotes actin cytoskeleton reorganization, cell migration and anchorage-independent cell growth”. J. Cell. Sci. 112 (12): 1825–34. PMID 10341202.
- Medley QG, Serra-Pagès C, Iannotti E i dr.. (2000). „The trio guanine nucleotide exchange factor is a RhoA target. Binding of RhoA to the trio immunoglobulin-like domain”. J. Biol. Chem. 275 (46): 36116–23. DOI:10.1074/jbc.M003775200. PMID 10948190.
- Bellanger JM, Astier C, Sardet C i dr.. (2001). „The Rac1- and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin”. Nat. Cell Biol. 2 (12): 888–92. DOI:10.1038/35046533. PMID 11146652.
- Gao Y, Xing J, Streuli M i dr.. (2002). „Trp(56) of rac1 specifies interaction with a subset of guanine nucleotide exchange factors”. J. Biol. Chem. 276 (50): 47530–41. DOI:10.1074/jbc.M108865200. PMID 11595749.
- Strausberg RL, Feingold EA, Grouse LH i dr.. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T i dr.. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.
- Skowronek KR, Guo F, Zheng Y, Nassar N (2004). „The C-terminal basic tail of RhoG assists the guanine nucleotide exchange factor trio in binding to phospholipids”. J. Biol. Chem. 279 (36): 37895–907. DOI:10.1074/jbc.M312677200. PMID 15199069.
- Zheng M, Simon R, Mirlacher M i dr.. (2004). „TRIO Amplification and Abundant mRNA Expression Is Associated with Invasive Tumor Growth and Rapid Tumor Cell Proliferation in Urinary Bladder Cancer”. Am. J. Pathol. 165 (1): 63–9. DOI:10.1016/S0002-9440(10)63275-0. PMC 1618551. PMID 15215162.
- Yoshizuka N, Moriuchi R, Mori T i dr.. (2004). „An alternative transcript derived from the trio locus encodes a guanosine nucleotide exchange factor with mouse cell-transforming potential”. J. Biol. Chem. 279 (42): 43998–4004. DOI:10.1074/jbc.M406082200. PMID 15308664.
- Gerhard DS, Wagner L, Feingold EA i dr.. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Portales-Casamar E, Briançon-Marjollet A, Fromont S i dr.. (2006). „Identification of novel neuronal isoforms of the Rho-GEF Trio”. Biol. Cell 98 (3): 183–93. DOI:10.1042/BC20050009. PMID 16033331.
- Tao WA, Wollscheid B, O'Brien R i dr.. (2005). „Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry”. Nat. Methods 2 (8): 591–8. DOI:10.1038/nmeth776. PMID 16094384.
- Adamowicz M, Radlwimmer B, Rieker RJ i dr.. (2006). „Frequent amplifications and abundant expression of TRIO, NKD2, and IRX2 in soft tissue sarcomas”. Genes Chromosomes Cancer 45 (9): 829–38. DOI:10.1002/gcc.20343. PMID 16752383.
- Olsen JV, Blagoev B, Gnad F i dr.. (2006). „Global, in vivo, and site-specific phosphorylation dynamics in signaling networks”. Cell 127 (3): 635–48. DOI:10.1016/j.cell.2006.09.026. PMID 17081983.
- Chhatriwala MK, Betts L, Worthylake DK, Sondek J (2007). „The DH and PH Domains of Trio Coordinately Engage Rho GTPases for their Efficient Activation”. J. Mol. Biol. 368 (5): 1307–20. DOI:10.1016/j.jmb.2007.02.060. PMC 1890047. PMID 17391702.
- Rojas RJ, Yohe ME, Gershburg S i dr.. (2007). „Gαq Directly Activates p63RhoGEF and Trio via a Conserved Extension of the Dbl Homology-associated Pleckstrin Homology Domain”. J. Biol. Chem. 282 (40): 29201–10. DOI:10.1074/jbc.M703458200. PMC 2655113. PMID 17606614.
