1,3-二甲基戊胺

1,3-二甲基戊胺
临床资料
其他名称	1,3-二甲基戊胺; 1,3-DMAA; 二甲基戊胺; DMAA
给药途径	鼻内喷剂（英语：nasal spray）、口服
ATC码	未分配;
药物动力学数据
生物半衰期	~8.5小时
识别信息
	IUPAC命名法 4-Methylhexan-2-amine; ;
CAS号	105-41-9
PubChem CID	7753;
ChemSpider	7467 ;
UNII	X49C572YQO;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID60861715 ;
ECHA InfoCard	100.002.997
化学信息
化学式	C7H17N
摩尔质量	115.22 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES CCC(C)CC(C)N;
	InChI InChI=1S/C7H17N/c1-4-6(2)5-7(3)8/h6-7H,4-5,8H2,1-3H3 ; Key:YAHRDLICUYEDAU-UHFFFAOYSA-N ;

甲基己胺（又称1,3-二甲基戊胺、1,3-DMAA、二甲基戊胺和DMAA；商品名Forthane和Geranamine）是一种由礼来公司发明并研发的间接拟交感神经药，自1948年以来作为一种吸入型鼻塞缓解剂（英语：nasal decongestant）投放市场，但于1970年代被停止销售。^[2]

自2006年以来，甲基己胺以许多名称作为兴奋剂或提高能量的补剂广泛销售，据说是因为它类似于老鹳草中的某些化合物，但因具有数个不良副作用而受到质疑，至少有五个死亡与含甲基己胺的补剂有关。^[3]它被许多运动管理局和政府机构禁止。即使FDA已发出几封警告信，^[4]截至2019年，这种化合物仍出现于运动和减肥补剂中。^[5]

参见

参考文献

^ 1,3-Dimethylpentylamine - Compound Summary. PubChem Compound. USA: National Center for Biotechnology Information. Identification and Related Records. 26 March 2005 [27 May 2012]. （原始内容存档于2014-03-01）.
^ Cohen, Pieter A. DMAA as a Dietary Supplement Ingredient. Archives of Internal Medicine. 9 July 2012, 172 (13): 1038–9. PMID 22566490. doi:10.1001/archinternmed.2012.1677 .
^ Singer, Natasha; Peter Lattman. F.D.A. Issues Warning on Workout Supplement. New York Times. April 16, 2013 [April 16, 2013]. （原始内容存档于2019-01-03）.
^ FDA, Center for Food Safety and Applied. Products & Ingredients - DMAA in Products Marketed as Dietary Supplements. FDA. May 2019 [2022-02-22]. （原始内容存档于2019-04-23）（英语）.
^ Cohen, Pieter A.; Wen, Anita; Gerona, Roy. Prohibited Stimulants in Dietary Supplements After Enforcement Action by the US Food and Drug Administration. JAMA Internal Medicine. 1 December 2018, 178 (12): 1721–1723. PMC 6583602 . PMID 30422217. doi:10.1001/jamainternmed.2018.4846.

外部链接

Stimulant Potentially Dangerous to Health, FDA Warns. U.S. Food and Drug Administration. April 11, 2013 [2022-02-22]. （原始内容存档于2014-02-01）.
Bussel, Igor I; Pavlov Jr, Andrey A. DMAA: Efficacious but is it Safe?. Science Based Medicine Blog. June 7, 2013 [2022-02-22]. （原始内容存档于2013-06-09）.

[1] 1,3-Dimethylpentylamine - Compound Summary. PubChem Compound. USA: National Center for Biotechnology Information. Identification and Related Records. 26 March 2005 [27 May 2012]. （原始内容存档于2014-03-01）.

[2] Cohen, Pieter A. DMAA as a Dietary Supplement Ingredient. Archives of Internal Medicine. 9 July 2012, 172 (13): 1038–9. PMID 22566490. doi:10.1001/archinternmed.2012.1677 .

[nyt-fda-3] Singer, Natasha; Peter Lattman. F.D.A. Issues Warning on Workout Supplement. New York Times. April 16, 2013 [April 16, 2013]. （原始内容存档于2019-01-03）.

[4] FDA, Center for Food Safety and Applied. Products & Ingredients - DMAA in Products Marketed as Dietary Supplements. FDA. May 2019 [2022-02-22]. （原始内容存档于2019-04-23）（英语）.

[5] Cohen, Pieter A.; Wen, Anita; Gerona, Roy. Prohibited Stimulants in Dietary Supplements After Enforcement Action by the US Food and Drug Administration. JAMA Internal Medicine. 1 December 2018, 178 (12): 1721–1723. PMC 6583602 . PMID 30422217. doi:10.1001/jamainternmed.2018.4846.

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